Padres vs. Giants Odds & Betting Predictions - May 6, 2026

Padres at Giants

7:45 pm • NBCS-BA
5 - 1
Starting Pitchers
pitcherteameraw-l
Adrian Houser logoA.HouserSan Francisco Giants logo6.190-4
Bradgley Rodriguez logoB.RodriguezSan Diego Padres logo1.530-1

Padres at Giants Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Padres
22-14
-1.5
-1.5+159
o8.5-105
-102
Giants
14-23
u8.5
+1.5-195
u8.5-112
-118
location pinWednesday 7:45 p.m.
May 06, 2026
Oracle ParkSan Francisco
Padres vs. Giants Expert Picks
Kyle Murray
Kyle Murray
Last 30d: 46-73-4 (-5.3u)
M.Waldron o3.5 Ks+124
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 101-98-3 (+12.0u)
SF -102
1.02u
Picks Office
Picks Office
Last 30d: 195-176-11 (+6.3u)
SD -105
0.95u
Join Discord for earlier access: https://discord.gg/HjKxYKdSUy San Diego is 21-14 and only 0.5 games off the NL West lead against a 14-22 Giants team sitting 8 games back. The Padres already put 10 on this same park today with a 14-hit attack, so the near pick'em price is hard to ignore. Both starters are still TBD, which keeps this on the cleaner team profile instead of a forced pitching story.
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 244-284-14 (+19.1u)
A.Houser u3.5 Ks-120
0.74u
#EV 5.92%
SF -0.5 (F5)+132
0.66u
#EV 3.51%

Padres vs. Giants Previews & Analysis

  • McGrath's Projection for Padres-Giants article feature image

    McGrath's Projection for Padres-Giants

    Tanner McGrath
    May 6, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Padres vs. Giants Public Betting Percentages

Away Logo

Padres

Public

63%

Bets%

37%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Giants
15-228-117-114-911-13
Padres
21-1512-79-812-99-6

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Giants
15-20-28-10-17-10-19-46-16-2
Padres
16-19-110-8-16-119-11-17-8

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Giants
14-238-116-125-89-15
Padres
22-1411-811-613-89-6

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 6thSDL 5-10-1.5 LO 7.5SD -149
May 5thSDW 3-2+1.5 WU 8SF +112
May 3rd@TBL 1-2+1.5 WU 8TB +104
May 2nd@TBL 1-5-1.5 LU 7.5TB -115
May 1st@TBL 0-3+1.5 LU 7.5TB +117

Giants vs. Padres Injury Updates

Giants Injuries

  • Hayden Birdsong
    SP

    Birdsong is out with arm

    Out

Padres Injuries

  • Joe Musgrove
    SP

    Musgrove is out with elbow

    Out

  • Will Wagner
    3B

    Wagner is out with oblique

    Out

Padres vs. Giants Box Score
Padres Player Stats
Projected
PITCHERPCIPKER
Bradgley Rodriguez logoRB.Rodriguez, P7100
Matt Waldron logoRM.Waldron, P67571
Adrian Morejon logoLA.Morejon, P26240
Mason Miller logoRM.Miller, P13120
HITTERSH-ABRHRRBI
Jackson Merrill logo1J.Merrill, CF1-4000
Manny Machado logo2M.Machado, 3B0-3100
Miguel Andujar logo3M.Andujar, DH0-4000
Gavin Sheets logo4G.Sheets, 1B1-3111
Xander Bogaerts logo4X.Bogaerts, SS1-1112
Fernando Tatis logo5F.Tatis, 2B0-4100
Ramon Laureano logo6R.Laureano, LF0-2100
Nick Castellanos logo7N.Castellanos, RF2-4000
Freddy Fermin logo8F.Fermin, C0-4000
Sung Mun Song logo9S.Song, SS0-2000
Ty France logo9T.France, PH1-2002
Ty France logo9T.France, 1B1-2002
Giants Player Stats
Projected
PITCHERPCIPKER
Adrian Houser logoRA.Houser, P74631
Keaton Winn logoRK.Winn, P160.201
Matt Gage logoLM.Gage, P100.100
Ryan Walker logoRR.Walker, P29102
Joel Peguero logoRJ.Peguero, P8110
HITTERSH-ABRHRRBI
Heliot Ramos logo1H.Ramos, LF0-4000
Jung Hoo Lee logo2J.Lee, CF0-4000
Casey Schmitt logo3C.Schmitt, 2B0-4000
Matt Chapman logo4M.Chapman, 3B0-3000
Rafael Devers logo5R.Devers, 1B1-3111
Willy Adames logo6W.Adames, SS0-3000
Bryce Eldridge logo7B.Eldridge, DH0-3000
Jesus Rodriguez logo8J.Rodriguez, RF2-3000
Patrick Bailey logo9P.Bailey, C0-3000

Padres vs. Giants Odds Comparison

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Padres at Giants Team Totals

MatchupOverUnder
Padres
22-14
N/A
N/A
Giants
14-23
N/A
N/A