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Padres vs. Giants Odds & Betting Predictions - May 6, 2026

Padres at Giants

1:45 am • NBCS-BA

San Diego Padres

20-14
@

San Francisco Giants

14-21
Starting Pitchers
pitcherteameraw-l
Logan Webb logoL.WebbSan Francisco Giants logo4.302-3
Walker Buehler logoW.BuehlerSan Diego Padres logo5.401-2

Padres at Giants Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Padres
20-14
+1.5
+1.5-187
o7.5-103
+112
Giants
14-21
u7.5
-1.5+155
u7.5-117
-133
location pinWednesday 1:45 a.m.
May 06, 2026
Oracle ParkSan Francisco
thermometer image59°Fahrenheit
rain image0%Rain
wind image9Wind
Padres vs. Giants Expert Picks
Sean Zerillo
Sean Zerillo
Last 30d: 154-147-15 (-7.1u)
Under 7.5-115
0.58u
Bet to -125 or 7 (-102)

Prop Odds Comparison

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No props found

Line Movement Tracker

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Padres vs. Giants Public Betting Percentages

Away Logo

Padres

Public

Home Logo

Giants

49%

Bets%

51%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Giants are 1-4 in their last 5 games.
  • Giants are 3-2 in their last 5 games against the spread
  • Giants are 7-11 in their road games against the spread
  • The totals have gone OVER in 1 of Giants' last 5 games
  • The totals have gone OVER in 7 of Giants' 17 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Giants		15-208-97-114-711-13
Padres		19-1512-77-812-97-6

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Giants		14-19-27-9-17-10-18-36-16-2
Padres		15-18-110-8-15-109-11-16-7

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Giants		14-218-96-125-69-15
Padres		20-1411-89-613-87-6

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 5thSDW 3-2+1.5 WU 8SF +112
May 3rd@TBL 1-2+1.5 WU 8TB +104
May 2nd@TBL 1-5-1.5 LU 7.5TB -115
May 1st@TBL 0-3+1.5 LU 7.5TB +117
Apr 30th@PHIL 5-6+1.5 WO 8.5PHI +119

Giants vs. Padres Injury Updates

Giants Injuries

  • Hayden Birdsong
    SP

    Birdsong is out with arm

    Out

Padres Injuries

  • Joe Musgrove
    SP

    Musgrove is out with elbow

    Out

  • Will Wagner
    3B

    Wagner is out with oblique

    Out

See more MLB Injuries Right Arrow
Padres vs. Giants Starting Lineups
Padres Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Walker Buehler logoRW.Buehler, P1-25.401.5608.64
HITTERSAVGOBPSLGHR
Ramon Laureano logo1R.Laureano, LF.238.301.4265
Fernando Tatis logo2F.Tatis, RF.252.324.3010
Jackson Merrill logo3J.Merrill, CF.220.283.3624
Manny Machado logo4M.Machado, 3B.221.328.3895
Xander Bogaerts logo5X.Bogaerts, SS.262.343.4025
Gavin Sheets logo6G.Sheets, 1B.215.263.4414
Miguel Andujar logo7M.Andujar, DH.305.337.4762
Luis Campusano logo8L.Campusano, C.300.352.6203
Jake Cronenworth logo9J.Cronenworth, 2B.144.272.1961
Giants Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Logan Webb logoRL.Webb, P2-34.291.3647.77
HITTERSAVGOBPSLGHR
Jung Hoo Lee logo1J.Lee, RF.272.321.4002
Casey Schmitt logo2C.Schmitt, 3B.308.359.5425
Luis Arraez logo3L.Arraez, 2B.316.340.3980
Heliot Ramos logo4H.Ramos, LF.270.306.4213
Rafael Devers logo5R.Devers, 1B.218.264.3082
Willy Adames logo6W.Adames, SS.197.236.3433
Bryce Eldridge logo7B.Eldridge, DH.000.333.0000
Patrick Bailey logo8P.Bailey, C.152.221.1901
Drew Gilbert logo9D.Gilbert, CF.255.296.3922

Padres vs. Giants Odds Comparison

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Padres at Giants Team Totals

MatchupOverUnder
Padres
20-14
N/A
N/A
Giants
14-21
N/A
N/A