Orioles vs. Guardians Odds & Betting Predictions - July 22, 2025

Orioles at Guardians

10:40 pm • CLEG
3 - 6
Starting Pitchers
pitcherteameraw-l
Joseph Cantillo logoJ.CantilloCleveland Guardians logo3.215-3
Brandon Young logoB.YoungBaltimore Orioles logo6.241-7

Orioles at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Orioles
0-0
+1.5
+1.5-162
o8-108
+135
Guardians
1-2
u8
-1.5+134
u8-111
-161
location pinTuesday 10:40 p.m.
July 22, 2025
Progressive FieldCleveland
Orioles vs. Guardians Expert Picks
The Propfessor
The Propfessor
Last 30d: 33-55-2 (+1.9u)
S.Kwan o1.5 Hits + Runs + RBIs-130
1u
Austin Pendergrass
Austin Pendergrass
Last 30d: 47-48-0 (-3.1u)
CLE -152
0.33u
Picks Office
Picks Office
Last 30d: 61-80-3 (-15.6u)
Under 8.5-115
1u
Follow @PicksOffice on X.
Brian Bitler
Brian Bitler
Last 30d: 74-72-1 (-6.5u)
BAL +125
3u
Capper Central
Capper Central
Last 30d: 94-56-1 (+24.5u)
CLE -135
1u

Orioles vs. Guardians Previews & Analysis

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    Orioles vs. Guardians: 2 Strikeout Props for Tuesday

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    Jul 22, 2025 UTC
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    3 MLB Player Props for Tuesday

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Prop Odds Comparison

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Line Movement Tracker

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Orioles vs. Guardians Public Betting Percentages

Away Logo

Orioles

Public

19%

Bets%

81%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians
86-7639-4247-3433-3651-38
Orioles
78-8437-4441-4025-4151-42

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians
69-87-637-41-332-46-334-34-134-50-5
Orioles
65-92-534-44-331-48-231-32-332-59-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians
88-7445-3643-3844-2543-46
Orioles
75-8739-4236-4532-3440-53

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jul 21stBALW 10-5-1.5 WO 8.5CLE -143
Jul 20thATHW 8-2+1.5 WO 7.5CLE -106
Jul 19thATHL 2-8-1.5 LO 9ATH -134
Jul 18thATHW 8-6-1.5 WO 8CLE -134
Jul 13th@CWSW 6-5-1.5 LO 8.5CLE -142

Guardians vs. Orioles Injury Updates

Guardians Injuries

  • Edward Lively
    SP

    Lively is out with elbow

    Out

  • John Means
    SP

    Means is out with elbow

    Out

Orioles Injuries

  • Grayson Rodriguez
    SP

    Rodriguez is out with elbow

    Out

Orioles vs. Guardians Box Score
Orioles Player Stats
Projected
PITCHERPCIPKER
Brandon Young logoRB.Young, P734.133
Andrew Kittredge logoRA.Kittredge, P60.210
Gregory Soto logoLG.Soto, P33122
Yennier Cano logoRY.Cano, P17101
Seranthony Dominguez logoRS.Dominguez, P14100
HITTERSH-ABRHRRBI
Jackson Holliday logo1J.Holliday, 2B1-4001
Jordan Westburg logo2J.Westburg, DH0-4000
Gunnar Henderson logo3G.Henderson, SS0-2000
Ramon Laureano logo4R.Laureano, RF1-4111
Boyce Mullins logo5C.Mullins, CF0-4000
Ramon Urias logo6R.Urias, 3B2-4100
Colton Cowser logo7C.Cowser, LF1-4000
Coby Mayo logo8C.Mayo, 1B1-1100
Jacob Stallings logo9J.Stallings, C0-2000
Ryan O'Hearn logo9R.O'Hearn, PH1-1000
Alex Jackson logo9A.Jackson, C0-1000
Guardians Player Stats
Projected
PITCHERPCIPKER
Joseph Cantillo logoLJ.Cantillo, P95551
Erik Sabrowski logoLE.Sabrowski, P231.221
Matthew Festa logoRM.Festa, P8001
Cade Smith logoRC.Smith, P311.110
Emmanuel Clase logoRE.Clase, P13110
HITTERSH-ABRHRRBI
Steven Kwan logo1S.Kwan, LF0-5000
Angel Martinez logo2A.Martinez, CF3-5101
Jose Ramirez logo3J.Ramirez, 3B1-2111
Kyle Manzardo logo4K.Manzardo, DH1-3002
Carlos Santana logo5C.Santana, 1B0-4000
Nolan Jones logo6N.Jones, RF0-3100
Daniel Schneemann logo7D.Schneemann, 2B1-2100
Brayan Rocchio logo8B.Rocchio, SS1-3102
Noah Naylor logo9B.Naylor, C0-2100

Orioles vs. Guardians Odds Comparison

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Orioles at Guardians Team Totals

MatchupOverUnder
Orioles
0-0
o3.5-109
u3.5-119
Guardians
1-2
o4.5+109
u4.5-139