Orioles vs. Guardians Odds & Betting Predictions - July 22, 2025

Orioles at Guardians

10:40 pm • CLEG

Baltimore Orioles

0-0

3 - 6

Cleveland Guardians

1-2

pitcher		team	era	w-l
J.Cantillo			3.21	5-3
B.Young			6.24	1-7

MatchupOpenSpreadTotalMoneyline
Orioles 0-0	+1.5	+1.5-162	o8-108	+135
Guardians 1-2	u8	-1.5+134	u8-111	-161

Tuesday 10:40 p.m.

July 22, 2025

Progressive FieldCleveland

S.Kwan o1.5 Hits + Runs + RBIs-130

CLE -152

0.33u

Under 8-104

1.04u

Flat Favorites at Home (***) Overall: 503-346-38,59% (ROI:15%) Season:10-8-1,56% (ROI:5%) Blowing In Ballparks (***) Overall: 865-541-72,62% (ROI:18%) Season:35-21-1,63% (ROI:19%)

Under 8.5-115

Follow @PicksOffice on X.

BAL +125

CLE -135

Orioles vs. Guardians: 2 Strikeout Props for Tuesday
Collin Whitchurch•
Jul 22, 2025 UTC
3 MLB Player Props for Tuesday
Alex Hinton•
Jul 22, 2025 UTC

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No props found

MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 1-4 in their last 5 games against the spread
Guardians are 47-34 in their road games against the spread
The totals have gone OVER in 2 of Guardians' last 5 games
The totals have gone OVER in 37 of Guardians' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	86-76	39-42	47-34	33-36	51-38
Orioles	78-84	37-44	41-40	25-41	51-42

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	69-87-6	37-41-3	32-46-3	34-34-1	34-50-5
Orioles	65-92-5	34-44-3	31-48-2	31-32-3	32-59-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	88-74	45-36	43-38	44-25	43-46
Orioles	75-87	39-42	36-45	32-34	40-53

date	opponent	score	spread	over/under	moneyline
Jul 21st	BAL	W 10-5	-1.5 W	O 8.5	CLE -143
Jul 20th	ATH	W 8-2	+1.5 W	O 7.5	CLE -106
Jul 19th	ATH	L 2-8	-1.5 L	O 9	ATH -134
Jul 18th	ATH	W 8-6	-1.5 W	O 8	CLE -134
Jul 13th	@CWS	W 6-5	-1.5 L	O 8.5	CLE -142

Grayson Rodriguez
SP
Rodriguez is out with elbow
Out
Pedro Leon
RF
Leon is out with knee
Out

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PITCHER	PC	IP	K	ER
RB.Young, P	73	4.1	3	3
RA.Kittredge, P	6	0.2	1	0
LG.Soto, P	33	1	2	2
RY.Cano, P	17	1	0	1
RS.Dominguez, P	14	1	0	0

HITTERS	H-AB	R	HR	RBI
1J.Holliday, 2B	1-4	0	0	1
2J.Westburg, DH	0-4	0	0	0
3G.Henderson, SS	0-2	0	0	0
4R.Laureano, RF	1-4	1	1	1
5C.Mullins, CF	0-4	0	0	0
6R.Urias, 3B	2-4	1	0	0
7C.Cowser, LF	1-4	0	0	0
8C.Mayo, 1B	1-1	1	0	0
9J.Stallings, C	0-2	0	0	0
9R.O'Hearn, PH	1-1	0	0	0
9A.Jackson, C	0-1	0	0	0

PITCHER	PC	IP	K	ER
LJ.Cantillo, P	95	5	5	1
LE.Sabrowski, P	23	1.2	2	1
RM.Festa, P	8	0	0	1
RC.Smith, P	31	1.1	1	0
RE.Clase, P	13	1	1	0

HITTERS	H-AB	R	HR	RBI
1S.Kwan, LF	0-5	0	0	0
2A.Martinez, CF	3-5	1	0	1
3J.Ramirez, 3B	1-2	1	1	1
4K.Manzardo, DH	1-3	0	0	2
5C.Santana, 1B	0-4	0	0	0
6N.Jones, RF	0-3	1	0	0
7D.Schneemann, 2B	1-2	1	0	0
8B.Rocchio, SS	1-3	1	0	2
9B.Naylor, C	0-2	1	0	0