Orioles vs. Guardians Odds & Betting Predictions - July 22, 2025

Orioles at Guardians

10:40 pm • CLEG

Baltimore Orioles

44-56

3 - 6

Cleveland Guardians

50-50

pitcher		team	era	w-l
J.Cantillo			3.91	2-0
B.Young			7.34	0-5

MatchupOpenSpreadTotalMoneyline
Orioles 44-56	+1.5	+1.5-162	o8-108	+135
Guardians 50-50	u8	-1.5+134	u8-111	-161

Tuesday 10:40 p.m.

July 22, 2025

Progressive FieldCleveland

S.Kwan o1.5 Hits + Runs + RBIs-130

CLE -152

0.33u

Under 8-104

1.04u

Flat Favorites at Home (***) Overall: 503-346-38,59% (ROI:15%) Season:10-8-1,56% (ROI:5%) Blowing In Ballparks (***) Overall: 865-541-72,62% (ROI:18%) Season:35-21-1,63% (ROI:19%)

Under 8.5-115

Follow @PicksOffice on X.

BAL +125

CLE -135

Orioles vs. Guardians: 2 Strikeout Props for Tuesday
Collin Whitchurch•
Jul 22, 2025 UTC
3 MLB Player Props for Tuesday
Alex Hinton•
Jul 22, 2025 UTC

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No props found

MLB Public Betting

Guardians are 4-1 in their last 5 games.
Guardians are 4-1 in their last 5 games against the spread
Guardians are 29-23 in their road games against the spread
The totals have gone OVER in 5 of Guardians' last 5 games
The totals have gone OVER in 24 of Guardians' 48 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	52-48	23-25	29-23	20-19	32-28
Orioles	42-58	18-29	24-29	16-32	24-26

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	44-52-4	24-23-1	20-29-3	21-18	23-33-4
Orioles	43-54-3	24-21-2	19-33-1	23-23-2	19-30-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	50-50	24-24	26-26	25-14	25-35
Orioles	44-56	22-25	22-31	21-27	21-29

date	opponent	score	spread	over/under	moneyline
Jul 21st	BAL	W 10-5	-1.5 W	O 8.5	CLE -143
Jul 20th	ATH	W 8-2	+1.5 W	O 7.5	CLE -106
Jul 19th	ATH	L 2-8	-1.5 L	O 9	ATH -134
Jul 18th	ATH	W 8-6	-1.5 W	O 8	CLE -134
Jul 13th	@CWS	W 6-5	-1.5 L	O 8.5	CLE -142

Gabriel Arias
SS
Arias is out with leg
Out
Ben Lively
SP
Lively is out with elbow
Out
Shane Bieber
SP
Bieber is out with elbow
Out
John Means
SP
Means is out with elbow
Out

Albert Suarez
RP
Suarez is out with shoulder
Out
Jorge Mateo
SS
Mateo is out with hamstring
Out
Kyle Bradish
SP
Bradish is out with elbow
Out
Grayson Rodriguez
SP
Rodriguez is out with elbow
Out
Tyler Wells
SP
Wells is out with elbow
Out
Adley Rutschman
C
Rutschman is out with oblique
Out
Cade Povich
SP
Povich is out with hip
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RB.Young, P	73	4.1	3	3
RA.Kittredge, P	6	0.2	1	0
LG.Soto, P	33	1	2	2
RY.Cano, P	17	1	0	1
RS.Dominguez, P	14	1	0	0

HITTERS	H-AB	R	HR	RBI
1J.Holliday, 2B	1-4	0	0	1
2J.Westburg, DH	0-4	0	0	0
3G.Henderson, SS	0-2	0	0	0
4R.Laureano, RF	1-4	1	1	1
5C.Mullins, CF	0-4	0	0	0
6R.Urias, 3B	2-4	1	0	0
7C.Cowser, LF	1-4	0	0	0
8C.Mayo, 1B	1-1	1	0	0
9J.Stallings, C	0-2	0	0	0
9R.O'Hearn, PH	1-1	0	0	0
9A.Jackson, C	0-1	0	0	0

PITCHER	PC	IP	K	ER
LJ.Cantillo, P	95	5	5	1
LE.Sabrowski, P	23	1.2	2	1
RM.Festa, P	8	0	0	1
RC.Smith, P	31	1.1	1	0
RE.Clase, P	13	1	1	0

HITTERS	H-AB	R	HR	RBI
1S.Kwan, LF	0-5	0	0	0
2A.Martinez, CF	3-5	1	0	1
3J.Ramirez, 3B	1-2	1	1	1
4K.Manzardo, DH	1-3	0	0	2
5C.Santana, 1B	0-4	0	0	0
6N.Jones, RF	0-3	1	0	0
7D.Schneemann, 2B	1-2	1	0	0
8B.Rocchio, SS	1-3	1	0	2
9B.Naylor, C	0-2	1	0	0