Orioles vs. Guardians Odds & Betting Predictions - July 22, 2025

Orioles at Guardians

10:40 pm • CLEG
3 - 6
Starting Pitchers
pitcherteameraw-l
Joey Cantillo logoJ.CantilloCleveland Guardians logo3.215-3
Brandon Young logoB.YoungBaltimore Orioles logo6.241-7

Orioles at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Orioles
0-0
+1.5
+1.5-162
o8-108
+135
Guardians
1-2
u8
-1.5+134
u8-111
-161
location pinTuesday 10:40 p.m.
July 22, 2025
Progressive FieldCleveland
Orioles vs. Guardians Expert Picks
The Propfessor
The Propfessor
Last 30d: 55-63-0 (-1.9u)
S.Kwan o1.5 Hits + Runs + RBIs-130
1u
Austin Pendergrass
Austin Pendergrass
Last 30d: 43-52-0 (-10.8u)
CLE -152
0.33u
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 244-219-11 (+12.7u)
Under 8-104
1.04u
Flat Favorites at Home (***) Overall: 503-346-38,59% (ROI:15%) Season:10-8-1,56% (ROI:5%) Blowing In Ballparks (***) Overall: 865-541-72,62% (ROI:18%) Season:35-21-1,63% (ROI:19%)
Picks Office
Picks Office
Last 30d: 216-174-7 (+27.6u)
Under 8.5-115
1u
Follow @PicksOffice on X.
Brian Bitler
Brian Bitler
Last 30d: 96-88-2 (+10.6u)
BAL +125
3u
Capper Central
Capper Central
Last 30d: 91-80-0 (-2.9u)
CLE -135
1u

Orioles vs. Guardians Previews & Analysis

  • Orioles vs. Guardians: 2 Strikeout Props for Tuesday article feature image

    Orioles vs. Guardians: 2 Strikeout Props for Tuesday

    Collin Whitchurch
    Jul 22, 2025 UTC
  • 3 MLB Player Props for Tuesday article feature image

    3 MLB Player Props for Tuesday

    Alex Hinton
    Jul 22, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Orioles vs. Guardians Public Betting Percentages

Away Logo

Orioles

Public

19%

Bets%

81%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians
86-7639-4247-3433-3651-38
Orioles
78-8437-4441-4025-4151-42

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians
69-87-637-41-332-46-334-34-134-50-5
Orioles
65-92-534-44-331-48-231-32-332-59-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians
88-7445-3643-3844-2543-46
Orioles
75-8739-4236-4532-3440-53

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jul 21stBALW 10-5-1.5 WO 8.5CLE -143
Jul 20thATHW 8-2+1.5 WO 7.5CLE -106
Jul 19thATHL 2-8-1.5 LO 9ATH -134
Jul 18thATHW 8-6-1.5 WO 8CLE -134
Jul 13th@CWSW 6-5-1.5 LO 8.5CLE -142

Guardians vs. Orioles Injury Updates

Guardians Injuries

    Orioles Injuries

    • Grayson Rodriguez
      SP

      Rodriguez is out with elbow

      Out

    • Pedro Leon
      RF

      Leon is out with knee

      Out

    Orioles vs. Guardians Box Score
    Orioles Player Stats
    Projected
    PITCHERPCIPKER
    Brandon Young logoRB.Young, P734.133
    Andrew Kittredge logoRA.Kittredge, P60.210
    Gregory Soto logoLG.Soto, P33122
    Yennier Cano logoRY.Cano, P17101
    Seranthony Dominguez logoRS.Dominguez, P14100
    HITTERSH-ABRHRRBI
    Jackson Holliday logo1J.Holliday, 2B1-4001
    Jordan Westburg logo2J.Westburg, DH0-4000
    Gunnar Henderson logo3G.Henderson, SS0-2000
    Ramon Laureano logo4R.Laureano, RF1-4111
    Cedric Mullins logo5C.Mullins, CF0-4000
    Ramon Urias logo6R.Urias, 3B2-4100
    Colton Cowser logo7C.Cowser, LF1-4000
    Coby Mayo logo8C.Mayo, 1B1-1100
    Jacob Stallings logo9J.Stallings, C0-2000
    Ryan O'Hearn logo9R.O'Hearn, PH1-1000
    Alex Jackson logo9A.Jackson, C0-1000
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Joey Cantillo logoLJ.Cantillo, P95551
    Erik Sabrowski logoLE.Sabrowski, P231.221
    Matt Festa logoRM.Festa, P8001
    Cade Smith logoRC.Smith, P311.110
    Emmanuel Clase logoRE.Clase, P13110
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, LF0-5000
    Angel Martinez logo2A.Martinez, CF3-5101
    Jose Ramirez logo3J.Ramirez, 3B1-2111
    Kyle Manzardo logo4K.Manzardo, DH1-3002
    Carlos Santana logo5C.Santana, 1B0-4000
    Nolan Jones logo6N.Jones, RF0-3100
    Daniel Schneemann logo7D.Schneemann, 2B1-2100
    Brayan Rocchio logo8B.Rocchio, SS1-3102
    Bo Naylor logo9B.Naylor, C0-2100

    Orioles vs. Guardians Odds Comparison

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    Orioles at Guardians Team Totals

    MatchupOverUnder
    Orioles
    0-0
    o3.5-109
    u3.5-119
    Guardians
    1-2
    o4.5+109
    u4.5-139