Orioles vs. Guardians Odds & Betting Predictions - July 22, 2025

Orioles at Guardians

10:40 pm • CLEG

Baltimore Orioles

0-0

3 - 6

Cleveland Guardians

1-2

pitcher		team	era	w-l
J.Cantillo			3.21	5-3
B.Young			6.24	1-7

MatchupOpenSpreadTotalMoneyline
Orioles 0-0	+1.5	+1.5-162	o8-108	+135
Guardians 1-2	u8	-1.5+134	u8-111	-161

Tuesday 10:40 p.m.

July 22, 2025

Progressive FieldCleveland

S.Kwan o1.5 Hits + Runs + RBIs-130

CLE -152

0.33u

Under 8-104

1.04u

Flat Favorites at Home (***) Overall: 503-346-38,59% (ROI:15%) Season:10-8-1,56% (ROI:5%) Blowing In Ballparks (***) Overall: 865-541-72,62% (ROI:18%) Season:35-21-1,63% (ROI:19%)

Under 8.5-115

Follow @PicksOffice on X.

BAL +125

CLE -135

Orioles vs. Guardians: 2 Strikeout Props for Tuesday
Collin Whitchurch•
Jul 22, 2025 UTC
3 MLB Player Props for Tuesday
Alex Hinton•
Jul 22, 2025 UTC

See more MLB Coverage

No props found

MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 1-4 in their last 5 games against the spread
Guardians are 47-34 in their road games against the spread
The totals have gone OVER in 2 of Guardians' last 5 games
The totals have gone OVER in 37 of Guardians' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	86-76	39-42	47-34	33-36	51-38
Orioles	78-84	37-44	41-40	25-41	51-42

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	69-87-6	37-41-3	32-46-3	34-34-1	34-50-5
Orioles	65-92-5	34-44-3	31-48-2	31-32-3	32-59-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	88-74	45-36	43-38	44-25	43-46
Orioles	75-87	39-42	36-45	32-34	40-53

date	opponent	score	spread	over/under	moneyline
Jul 21st	BAL	W 10-5	-1.5 W	O 8.5	CLE -143
Jul 20th	ATH	W 8-2	+1.5 W	O 7.5	CLE -106
Jul 19th	ATH	L 2-8	-1.5 L	O 9	ATH -134
Jul 18th	ATH	W 8-6	-1.5 W	O 8	CLE -134
Jul 13th	@CWS	W 6-5	-1.5 L	O 8.5	CLE -142

Ben Lively
SP
Lively is out with elbow
Out
John Means
SP
Means is out with elbow
Out

Grayson Rodriguez
SP
Rodriguez is out with elbow
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RB.Young, P	73	4.1	3	3
RA.Kittredge, P	6	0.2	1	0
LG.Soto, P	33	1	2	2
RY.Cano, P	17	1	0	1
RS.Dominguez, P	14	1	0	0

HITTERS	H-AB	R	HR	RBI
1J.Holliday, 2B	1-4	0	0	1
2J.Westburg, DH	0-4	0	0	0
3G.Henderson, SS	0-2	0	0	0
4R.Laureano, RF	1-4	1	1	1
5C.Mullins, CF	0-4	0	0	0
6R.Urias, 3B	2-4	1	0	0
7C.Cowser, LF	1-4	0	0	0
8C.Mayo, 1B	1-1	1	0	0
9J.Stallings, C	0-2	0	0	0
9R.O'Hearn, PH	1-1	0	0	0
9A.Jackson, C	0-1	0	0	0

PITCHER	PC	IP	K	ER
LJ.Cantillo, P	95	5	5	1
LE.Sabrowski, P	23	1.2	2	1
RM.Festa, P	8	0	0	1
RC.Smith, P	31	1.1	1	0
RE.Clase, P	13	1	1	0

HITTERS	H-AB	R	HR	RBI
1S.Kwan, LF	0-5	0	0	0
2A.Martinez, CF	3-5	1	0	1
3J.Ramirez, 3B	1-2	1	1	1
4K.Manzardo, DH	1-3	0	0	2
5C.Santana, 1B	0-4	0	0	0
6N.Jones, RF	0-3	1	0	0
7D.Schneemann, 2B	1-2	1	0	0
8B.Rocchio, SS	1-3	1	0	2
9B.Naylor, C	0-2	1	0	0