Guardians vs. Cardinals Odds & Betting Predictions - April 15, 2026

Guardians at Cardinals

5:15 pm • CARD

Cleveland Guardians

@

St. Louis Cardinals

pitcher		team	era	w-l
D.May			9.45	1-2
S.Cecconi			5.75	0-2

MatchupOpenSpreadTotalMoneyline
Guardians 10-8	-1.5	-1.5+161	o8.5-106	-106
Cardinals 9-8	u8.5	+1.5-180	u8.5-113	-113

location pin

Wednesday 5:15 p.m.

April 15, 2026

Busch StadiumSt. Louis

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76°Fahrenheit

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30%Rain

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12Wind

Over 8.5-105

0.5u

CLE +100

1u

Zerillo's Opening Pitch for Wednesday
Sean Zerillo•
Apr 15, 2026 UTC

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MLB Public Betting

Cardinals are 2-3 in their last 5 games.
Cardinals are 2-3 in their last 5 games against the spread
Cardinals are 3-3 in their road games against the spread
The totals have gone OVER in 4 of Cardinals' last 5 games
The totals have gone OVER in 7 of Cardinals' 11 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cardinals	9-8	6-5	3-3	1-1	8-7
Guardians	11-7	5-1	6-6	3-1	8-6

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cardinals	10-6-1	7-4	3-2-1	1-1	9-5-1
Guardians	9-9	2-4	7-5	2-2	7-7

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cardinals	9-8	6-5	3-3	1-1	8-7
Guardians	10-8	4-2	6-6	3-1	7-7

date	opponent	score	spread	over/under	moneyline
Apr 14th	CLE	W 6-5	+1.5 W	O 9	STL +100
Apr 13th	CLE	L 3-9	+1.5 L	O 8	CLE +100
Apr 12th	BOS	L 3-9	+1.5 L	O 9	BOS +110
Apr 11th	BOS	L 1-7	+1.5 L	O 7.5	BOS +118
Apr 11th	BOS	W 3-2	+1.5 W	U 7.5	STL +115

Jose Fermin
2B
Jose Fermin has been scratched Tuesday.
Out
Lars Nootbaar
LF
Nootbaar is out with heel
Out
Hunter Dobbins
SP
Dobbins is out with knee
Out

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PITCHER		W-L	ERA	WHIP	K/9
RS.Cecconi, P		0-2	5.75	1.213	8.04

HITTERS	AVG	OBP	SLG	HR
1S.Kwan, CF	.258	.343	.339	1
2C.DeLauter, RF	.300	.379	.680	5
3J.Ramirez, 3B	.200	.297	.354	2
4K.Manzardo, 1B	.116	.224	.186	1
6A.Martinez, LF	.319	.385	.511	2
7J.Brito, 2B	.273	.333	.364	0
8A.Hedges, C	.350	.391	.450	0
9B.Rocchio, SS	.200	.344	.340	2

PITCHER		W-L	ERA	WHIP	K/9
RD.May, P		1-2	9.45	1.800	7.42

HITTERS	AVG	OBP	SLG	HR
1J.Wetherholt, 2B	.213	.329	.279	1
2I.Herrera, DH	.193	.365	.246	0
3A.Burleson, 1B	.271	.380	.424	2
4J.Walker, RF	.333	.394	.767	8
5N.Gorman, 3B	.208	.298	.333	2
6M.Winn, SS	.175	.353	.250	0
7N.Church, LF	.143	.189	.229	1
8P.Pages, C	.194	.257	.323	1
9V.Scott, CF	.256	.267	.279	0

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MatchupOverUnder
Guardians 10-8	N/A	N/A
Cardinals 9-8	N/A	N/A