Giants vs. Padres Odds & Betting Predictions - August 21, 2025

Giants at Padres

1:40 am • MLB Network

San Francisco Giants

61-65

1 - 6

San Diego Padres

70-56

MatchupOpenSpreadTotalMoneyline
Giants 61-65	+1.5	+1.5-188	o8-111	+118
Padres 70-56	u8	-1.5+151	u8-110	-140

Thursday 1:40 a.m.

August 21, 2025

PETCO ParkSan Diego

SF +125

1.5u

SF +116

🔑 Giants ML +116 (FanDuel) 3u Hammer time. JP Sears making his 1st start back with the Padres. He’s awful plain and simple. Roupp been solid all year, and the Giants are due for a W vs the Padres. 75% of money on SD. Fade the public here

Under 8-108

0.55u

🔗 https://whop.com/checkout/plan_EmUfhfnU87m47/?a=userd0a02663735&d2c=true

Under 8-110

Banger.

Under 8-105

0.53u

Tailing @Zerillo

Under 8-105

0.53u

Bet to -110

Over 8-110

📊 28-7 W/L (80%) ROI ~ 48.56% ROI L10 ~ 7-3 📈 Giants Series Closers Overs ✅ O/U is between 8 and 9 ✅ Teams ML is less than -120 ✅ Team is Giants ✅ Game number in series is 3 or 4

F.Tatis o1.5 Hits + Runs + RBIs-145

Action Network Exclusive Pick

Over 8-110

1.1u

Giants vs Padres: F5 Run Line Pick for Wednesday
John Feltman•
Aug 21, 2025 UTC
Wednesday's MLB Best Bets
Action Network Staff•
Aug 20, 2025 UTC

See more MLB Coverage

No props found

MLB Public Betting

Padres are 1-4 in their last 5 games.
Padres are 3-2 in their last 5 games against the spread
Padres are 36-30 in their road games against the spread
The totals have gone OVER in 1 of Padres' last 5 games
The totals have gone OVER in 25 of Padres' 60 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Padres	69-57	33-27	36-30	31-37	37-20
Giants	53-73	24-39	29-34	25-51	27-21

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Padres	51-71-4	25-34-1	26-37-3	34-32-2	17-38-2
Giants	56-66-4	24-38-1	32-28-3	26-49-1	28-17-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Padres	70-56	39-21	31-35	41-27	28-29
Giants	61-65	30-33	31-32	38-38	22-26

date	opponent	score	spread	over/under	moneyline
Aug 20th	SF	W 5-1	-1.5 W	U 8	SD -189
Aug 19th	SF	L 3-4	-1.5 L	U 7.5	SF -149
Aug 17th	@LAD	L 4-5	+1.5 W	O 8.5	LAD +120
Aug 17th	@LAD	L 0-6	+1.5 L	U 7.5	LAD +103
Aug 16th	@LAD	L 2-3	+1.5 W	U 9	LAD +120

Tom Murphy
C
Murphy is out with back
Out

Joe Musgrove
SP
Musgrove is out for season with elbow
Out for Season
Michael King
SP
Michael King (shoulder) has been scratched Saturday. Sean Reynolds will start for the Padres.
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RL.Roupp, P	65	2.1	2	5
LJ.Lucchesi, P	18	0.2	1	1
RT.Beck, P	8	0	0	0

HITTERS	H-AB	R	HR	RBI
1H.Ramos, LF	0-2	0	0	0
2R.Devers, 1B	0-2	0	0	0
3W.Adames, SS	0-2	0	0	0
4W.Flores, DH	0-2	0	0	0
5C.Schmitt, 3B	1-2	1	1	1
6J.Lee, CF	1-2	0	0	0
7C.Koss, 2B	1-2	0	0	0
8T.Fitzgerald, RF	0-0	0	0	0
9P.Bailey, C	0-1	0	0	0

PITCHER		PC	IP	K	ER
LJ.Sears, P		64	4	2	1

HITTERS	H-AB	R	HR	RBI
1F.Tatis, RF	1-2	1	0	0
2L.Arraez, DH	0-2	0	0	0
3M.Machado, 3B	1-2	1	1	1
4R.O'Hearn, 1B	1-1	1	0	1
5R.Laureano, CF	1-2	1	0	0
6G.Sheets, LF	2-2	2	2	4
7J.Iglesias, SS	0-2	0	0	0
8J.Cronenworth, 2B	0-1	0	0	0
9F.Fermin, C	0-2	0	0	0