Diamondbacks vs. Cardinals Odds & Betting Predictions - June 22, 2026

Diamondbacks at Cardinals

11:45 pm • ARID

Arizona Diamondbacks

39-39

2 - 3

St. Louis Cardinals

42-34

pitcher		team	era	w-l
A.Pallante			3.59	9-4
M.Kelly			5.71	5-7

MatchupOpenSpreadTotalMoneyline
Diamondbacks 39-39	+1.5	+1.5-163	o8.5-113	+126
Cardinals 42-34	u8.5	-1.5+137	u8.5-106	-151

Monday 11:45 p.m.

June 22, 2026

Busch StadiumSt. Louis

STL -145

0.69u

ARI +133

STL o4.5-104

1.04u

STL -142

0.35u

STL -0.5 (F5)-105

A.Burleson o1.5 Total Bases+105

A.Pallante o17.5 Outs-120

STL -140

L.Nootbaar o1.5 Hits + Runs + RBIs-105

1.05u

STL o4.5-104

0.52u

(FD) See notes on STL F5

STL -145 (F5)

(B365) Kelly 4.47 Bot ERA (only est. < 5) - 7.50 xERA range, Pallante 3.64 dERA - 4.37 Bot ERA. STL 119 proj LU (6 BRR) wRC+ v RHP/L30 days, ARI 88/90. Defenses both great. ARI pen estimators 1/2 run worse L30 days, but BARTOLO rates them better than STL, so F5. Also 0.5u on STL o4.5 (-104 FD) (not available to track yet)

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No props found

MLB Public Betting

Cardinals are 2-3 in their last 5 games.
Cardinals are 1-4 in their last 5 games against the spread
Cardinals are 23-14 in their road games against the spread
The totals have gone OVER in 3 of Cardinals' last 5 games
The totals have gone OVER in 17 of Cardinals' 39 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cardinals	45-31	22-17	23-14	10-8	35-22
Diamondbacks	44-34	23-18	21-16	18-19	25-15

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cardinals	33-39-4	17-20-2	16-19-2	7-10-1	25-29-3
Diamondbacks	33-42-3	16-24-1	17-18-2	13-23-1	19-19-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cardinals	42-34	22-17	20-17	13-5	29-28
Diamondbacks	39-39	24-17	15-22	22-15	16-24

date	opponent	score	spread	over/under	moneyline
Jun 21st	@KC	W 12-10	-1.5 W	O 9	STL -127
Jun 20th	@KC	L 5-6	-1.5 L	O 9.5	KC -120
Jun 18th	@KC	L 6-14	-1.5 L	O 9	KC -105
Jun 17th	SD	L 1-6	-1.5 L	U 10.5	SD -122
Jun 16th	SD	W 3-2	-1.5 L	U 8	STL -116

Corbin Burnes
SP
Burnes is out with elbow
Out
Blake Walston
SP
Walston is out with elbow
Out
Tyler Locklear
1B
Locklear is out with elbow
Out

Cristian Mena
SP
Mena is doubtful with shoulder
Doubtful

Masyn Winn
SS
Masyn Winn (thumb) has been scratched Tuesday.
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RM.Kelly, P	96	6	2	3
RT.Clarke, P	27	1.2	2	0
RJ.Loaisiga, P	4	0.1	0	0

HITTERS	H-AB	R	HR	RBI
1K.Marte, 2B	2-4	0	0	0
2G.Perdomo, SS	0-4	0	0	0
3C.Carroll, RF	2-4	1	0	0
4P.Smith, 1B	0-3	0	0	0
4I.Vargas, PH	0-1	0	0	0
4I.Vargas, 1B	0-1	0	0	0
5N.Arenado, 3B	1-4	0	0	1
6A.Del Castillo, C	1-4	0	0	0
7L.Gurriel, DH	0-3	0	0	0
8T.Troy, LF	1-4	1	1	1
9T.Tawa, CF	1-3	0	0	0

PITCHER	PC	IP	K	ER
RA.Pallante, P	85	6	2	1
RR.Stanek, P	11	0.2	0	1
LJ.Romero, P	9	1	0	0
RG.Soriano, P	5	0.1	0	0
RR.O'Brien, P	17	1	0	0

HITTERS	H-AB	R	RBI
1J.Wetherholt, 2B	2-4	0	0
2I.Herrera, C	1-3	0	0
3A.Burleson, 1B	1-2	0	1
4J.Walker, RF	0-4	0	0
5L.Nootbaar, LF	0-2	1	0
6M.Winn, SS	1-4	1	0
7J.Crooks, DH	0-3	0	0
8B.Jordan, 3B	0-2	0	1
9N.Church, CF	2-3	1	1