Cubs vs. Pirates Odds & Betting Predictions - September 16, 2025

Cubs at Pirates

10:40 pm • SportsNet PT

Chicago Cubs

4

4 - 1

Pittsburgh Pirates

1

pitcher		team	era	w-l
P.Skenes			1.97	10-10
C.Horton			2.67	11-4

MatchupOpenSpreadTotalMoneyline
Cubs 2-3	+1.5	+1.5-209	o6.5-117	+111
Pirates 0-0	u7	-1.5+172	u6.5-105	-131

location pin

Tuesday 10:40 p.m.

September 16, 2025

PNC ParkPittsburgh

Under 0.5 (1st Inn)-170

0.86u

CHC +110

1.1u

Under 6.5+100

1u

CHC +145 (F5)

1.45u

CHC +120

1.2u

@cowhitchurch https://myaction.app/F6GEecjhIWb

P.Skenes u6.5 Ks+115

1.15u

@DerekCarty https://myaction.app/F6GEecjhIWb

PIT -125

3u

CHC +115

0.58u

Bet to +108

Cubs vs Pirates: Workload Could Tip the Balance
Collin Whitchurch•
Sep 16, 2025 UTC
Grants Dinger Tuesday HR Picks!!!
•
Sep 16, 2025 UTC

See more MLB Coverage

No props found

MLB Public Betting

Pirates are 3-2 in their last 5 games.
Pirates are 4-1 in their last 5 games against the spread
Pirates are 42-39 in their road games against the spread
The totals have gone OVER in 1 of Pirates' last 5 games
The totals have gone OVER in 33 of Pirates' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Pirates	90-72	48-33	42-39	19-26	69-45
Cubs	78-84	39-42	39-42	55-60	22-24

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Pirates	61-92-9	33-43-5	28-49-4	17-26-2	42-65-7
Cubs	74-78-10	40-36-5	34-42-5	52-56-7	22-21-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Pirates	71-91	44-37	27-54	22-23	48-66
Cubs	92-70	50-31	42-39	73-42	18-28

date	opponent	score	spread	over/under	moneyline
Sep 15th	CHC	L 0-4	+1.5 L	U 8	CHC +102
Sep 14th	@WSH	L 3-4	-1.5 L	U 8.5	WSH -120
Sep 13th	@WSH	W 5-1	-1.5 W	U 9	PIT -115
Sep 12th	@WSH	L 5-6	-1.5 L	O 8.5	WSH -110
Sep 11th	@BAL	L 2-3	+1.5 W	U 8	BAL +105

Johan Oviedo
P
Oviedo is questionable with elbow
Questionable

Endy Rodriguez
C
Rodriguez is out with elbow
Out
Jared Jones
P
Jones is out with elbow
Out

Michael Soroka
P
Soroka is out with shoulder
Out
Justin Steele
P
Steele is out for season with elbow
Out for Season

See more MLB Injuries

PITCHER		PC	IP	K	ER
RC.Horton, P		79	5	6	1
LD.Pomeranz, P		15	1	2	0
RA.Kittredge, P		11	1	2	0
LC.Thielbar, P		12	1	0	0
RB.Keller, P		12	1	2	0

HITTERS	H-AB	R	HR	RBI
1M.Busch, 1B	3-4	2	1	1
2N.Hoerner, 2B	3-5	0	0	0
3I.Happ, LF	0-2	1	0	1
4M.Ballesteros, DH	2-4	1	0	0
5C.Kelly, C	2-5	0	0	0
6P.Crow-Armstrong, CF	1-4	0	0	2
7D.Swanson, SS	2-4	0	0	0
8W.Castro, RF	0-5	0	0	0
9M.Shaw, 3B	1-4	0	0	0

PITCHER		PC	IP	K	ER
RP.Skenes, P		92	3.2	6	3
LE.Sisk, P		21	1	1	1
RJ.Lawrence, P		17	1.1	1	0
RC.Mlodzinski, P		55	3	5	0

HITTERS	H-AB	R	HR	RBI
1J.Triolo, 3B	0-4	0	0	0
2S.Horwitz, 1B	1-3	1	0	0
3B.Reynolds, DH	0-4	0	0	0
4O.Cruz, CF	1-4	0	0	1
5N.Gonzales, SS	0-4	0	0	0
6J.Suwinski, LF	0-3	0	0	0
7N.Yorke, 2B	0-3	0	0	0
8A.Canario, RF	1-3	0	0	0
9H.Davis, C	1-3	0	0	0

Could not load odds

See more MLB Odds

MatchupOverUnder
Cubs 2-3	o2.5-147	u2.5+117
Pirates 0-0	o3.5+106	u3.5-136