Cubs vs. Pirates Odds & Betting Predictions - September 16, 2025

Cubs at Pirates

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Chicago Cubs

@

Pittsburgh Pirates

pitcher		team	era	w-l
P.Skenes			1.92	10-9
C.Horton			2.70	10-4

MatchupOpenSpreadTotalMoneyline
Cubs 86-64	+1.5	+1.5-205	o6.5-120	+115
Pirates 65-86	u7	-1.5+167	u6.5+100	-135

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Tuesday 10:40 p.m.

September 16, 2025

PNC ParkPittsburgh

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75°Fahrenheit

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0%Rain

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3Wind

CHC +120

1u

@cowhitchurch https://myaction.app/F6GEecjhIWb

P.Skenes u6.5 Ks+115

1u

@DerekCarty https://myaction.app/F6GEecjhIWb

PIT -125

3u

CHC +115

0.5u

Bet to +108

Cubs vs Pirates: Workload Could Tip the Balance
Collin Whitchurch•
Sep 16, 2025 UTC

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No props found

MLB Public Betting

Pirates are 1-4 in their last 5 games.
Pirates are 2-3 in their last 5 games against the spread
Pirates are 37-38 in their road games against the spread
The totals have gone OVER in 1 of Pirates' last 5 games
The totals have gone OVER in 31 of Pirates' 76 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Pirates	82-69	45-31	37-38	18-25	62-43
Cubs	70-80	35-40	35-40	50-58	19-22

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Pirates	58-85-8	31-40-5	27-45-3	16-25-2	40-59-6
Cubs	67-74-9	35-35-5	32-39-4	46-55-7	21-18-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Pirates	65-86	42-34	23-52	21-22	43-62
Cubs	86-64	46-29	40-35	68-40	17-24

date	opponent	score	spread	over/under	moneyline
Sep 15th	CHC	L 0-4	+1.5 L	U 8	CHC +102
Sep 14th	@WSH	L 3-4	-1.5 L	U 8.5	WSH -120
Sep 13th	@WSH	W 5-1	-1.5 W	U 9	PIT -115
Sep 12th	@WSH	L 5-6	-1.5 L	O 8.5	WSH -110
Sep 11th	@BAL	L 2-3	+1.5 W	U 8	BAL +105

Johan Oviedo
SP
Oviedo is questionable with elbow
Questionable

Endy Rodriguez
1B
Rodriguez is out with elbow
Out
Jared Jones
SP
Jones is out with elbow
Out

Michael Soroka
SP
Soroka is out with shoulder
Out
Justin Steele
SP
Steele is out for season with elbow
Out for Season

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PITCHER		W-L	ERA	WHIP	K/9
RC.Horton, P		10-4	2.70	1.109	7.28

HITTERS	AVG	OBP	SLG	HR
1M.Busch, 1B	.255	.333	.486	28
2N.Hoerner, 2B	.299	.348	.399	6
3I.Happ, LF	.242	.344	.421	22
4M.Ballesteros, DH	.281	.361	.469	1
5C.Kelly, C	.254	.340	.447	17
6P.Crow-Armstrong, CF	.248	.290	.486	29
7D.Swanson, SS	.248	.302	.422	22
8W.Castro, RF	.245	.335	.407	10
9M.Shaw, 3B	.223	.291	.380	11

PITCHER		W-L	ERA	WHIP	K/9
RP.Skenes, P		10-9	1.92	0.921	10.26

HITTERS	AVG	OBP	SLG	HR
1J.Triolo, SS	.227	.322	.358	6
2S.Horwitz, 1B	.260	.336	.406	9
3B.Reynolds, RF	.243	.313	.399	15
4T.Pham, LF	.249	.330	.374	9
5A.McCutchen, DH	.239	.334	.376	13
6N.Gonzales, 2B	.275	.315	.382	5
7O.Cruz, CF	.204	.305	.382	19
8C.Devanney, 3B	.094	.121	.125	0
9H.Davis, C	.157	.230	.265	6

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MatchupOverUnder
Cubs 86-64	N/A	N/A
Pirates 65-86	N/A	N/A