Wyoming vs. Colorado Odds & Betting Predictions - September 21, 2025

Wyoming at Colorado

2:15 am • ESPN

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Wyoming Cowboys

@

Colorado Buffaloes

MatchupOpenSpreadTotalMoneyline
Wyoming 2-1	+17.5	+13.5-115	o44.5-105	+380
Colorado 1-2	u47.5	-13.5-105	u44.5-115	-530

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Sunday 2:15 a.m.

September 21, 2025

Folsom FieldBoulder

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68°Fahrenheit

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0%Rain

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5Wind

No props found

NCAAF Public Betting

Colorado are 1-2 in their last 5 games.
Colorado are 1-2 in their last 5 games against the spread
Colorado are 0-1 in their road games against the spread
The totals have gone OVER in 1 of Colorado' last 3 games
The totals have gone OVER in 0 of Colorado' 2 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Colorado	1-2	1-1	0-1	1-0	0-2
Wyoming	2-1	1-1	1-0	2-0	0-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Colorado	1-2	0-2	1-0	0-1	1-1
Wyoming	0-3	0-2	0-1	0-2	0-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Colorado	1-2	N/A	N/A	1-0	0-2
Wyoming	2-1	N/A	N/A	2-0	0-1

date	opponent	score	spread	over/under	moneyline
Sep 12th	@HOU	L 20-36	+4 L	O 45.5	HOU +160
Sep 6th	DEL	W 31-7	-23.5 W	U 49.5	COLO -2800
Aug 30th	GT	L 20-27	+3 L	U 49.5	GT +136
Dec 29th	BYU	L 14-36	-3 L	U 55	BYU -155
Nov 29th	OKST	W 52-0	-14.5 W	U 67	COLO -650

Total

Passing

558

YDS

631

51/85

Comps/Atts

58/95

6.56

YPA

6.64

3/2

TDs/INTs

4/2

6/73

Sacks/Yards

9/51

Rushing

476

Rush Yards

372

110

Attempts

93

4.33

YPC

4

3

TDs

5

Turnovers

Fumbles Lost

2

Interceptions

2

Efficiency

6/7 85.7%

Redzone

7/7 100%

16/42 0%

3rd Down

16/43 0%

3/5 0%

4th Down

3/4 0%

First Downs

59

Total

55

21

Pass

25

33

Rush

23

5

Penalty

7

Misc

/

Penalties/Yards

/

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MatchupOverUnder
Wyoming 2-1	N/A	N/A
Colorado 1-2	N/A	N/A