Owls vs. Panthers Odds & Betting Predictions - October 21, 2025
Owls at Panthers
11:00 pm • ESPN2Owls at Panthers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Owls 10-4 | +1.5 | +1.5-115 | o48.5-115 | -155 |
Panthers 7-6 | u49.5 | -1.5-105 | u48.5-105 | +130 |

Pitbull StadiumMiami
Owls vs. Panthers Expert Picks
Mike Calabrese
Last 30d: 53-55-1 (+2.4u)
FIU +17.5 (Live)-105
1u
VegasIsMyBitch
Last 30d: 24-17-0 (+4.3u)
FIU +3-105
0.5u
John Feltman
Last 30d: 45-51-3 (-12.0u)
FIU +3-110
3.3u
Stuck 🚨
Last 30d: 47-53-1 (-2.8u)
FIU +3-107
0.3u
Forgot to log this earlier in week from pod. Can look live too
Mike Calabrese
Last 30d: 53-55-1 (+2.4u)
KENN -2.5-125
1u
🔑 1 banged up?
Wags Wins
Last 30d: 271-289-5 (-31.6u)
Over 48.5-120
1.25u
Scott Rickenbach
Last 30d: 111-101-2 (-5.9u)
KENN -155
0.65u
Duck
Last 30d: 86-77-0 (-0.8u)
FIU +130
0.3u
Roger Goodell
Last 30d: 6-13-0 (-9.6u)
FIU +130
0.5u
💰🦡 Jake
Last 30d: 87-101-3 (+11.0u)
Under 24.5 (1H)-113
1.13u
Mike Ianniello
Last 30d: 10-18-0 (-75.3u)
FIU +3.5-120
10u
Anders
Last 30d: 8-14-0 (-7.0u)
FIU +3.5-115
1.15u
Duck
Last 30d: 86-77-0 (-0.8u)
FIU +3.5-113
1.13u
Action article write up coming.
Top Shelf Action 🥃
Last 30d: 140-147-1 (-19.4u)
KENN -115
0.78u
Collin Wilson
Last 30d: 8-9-3 (-1.3u)
FIU +2.5-118
1.18u
Project FIU -2; Panthers defense should dominate in passing downs, also top 30 defensive finishing drives. FIU rush explosives advantage over Kennesaw D
Owls vs. Panthers Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Owls vs. Panthers Public Betting Percentages
Betting Trends
- Panthers are 3-2 in their last 5 games.
- Panthers are 3-2 in their last 5 games against the spread
- Panthers are 4-2 in their road games against the spread
- The totals have gone OVER in 3 of Panthers' last 5 games
- The totals have gone OVER in 3 of Panthers' 6 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Panthers vs. Owls Injury Updates

Panthers Injuries
- Jake HelfrichQB
Helfrich is out for season with chest
Out for Season

Owls Injuries
Team Stats
284
YDS
296
12/17
Comps/Atts
22/37
16.705882352941178
YPA
8
2/0
TDs/INTs
1/0
0/0
Sacks/Yards
2/11
Owls vs. Panthers Odds Comparison
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Owls at Panthers Team Totals
MatchupOverUnder | ||
|---|---|---|
Owls 10-4 | N/A | N/A |
Panthers 7-6 | N/A | N/A |




