Duke vs. Clemson Odds & Betting Predictions - November 1, 2025

Duke at Clemson

4:00 pm • ACC Network

Duke Blue Devils

5-5

46 - 45

Clemson Tigers

5-5

MatchupOpenSpreadTotalMoneyline
Duke 5-5	+2.5	+4-110	o54.5-115	+155
Clemson 5-5	u53.5	-4-110	u54.5-115	-188

Saturday 4:00 p.m.

November 01, 2025

Memorial Stadium (Clemson, SC)Clemson

A.Williams o4.5 Recs-145

0.69u

DUKE +3.5-105

2.86u

Q.Brown o44.5 Rec Yds-114

Over 54.5-110

0.91u

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DUKE +4-110

0.36u

Boomer’s Book

DUKE +140

1.4u

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CLEM -2.5-136

0.6u

Duke vs Clemson PRO System Pick
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Nov 1, 2025 UTC
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NCAAF Public Betting

Clemson are 2-3 in their last 5 games.
Clemson are 1-4 in their last 5 games against the spread
Clemson are 3-1 in their road games against the spread
The totals have gone OVER in 3 of Clemson' last 5 games
The totals have gone OVER in 3 of Clemson' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Clemson	4-6	1-5	3-1	3-6	1-0
Duke	4-6	1-4	3-2	3-4	1-2

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Clemson	4-6	3-3	1-3	4-5	0-1
Duke	7-3	3-2	4-1	4-3	3-0

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Clemson	5-5	N/A	N/A	4-5	1-0
Duke	5-5	N/A	N/A	4-3	1-2

date	opponent	score	spread	over/under	moneyline
Oct 18th	SMU	L 24-35	-3.5 L	O 49.5	SMU -180
Oct 11th	@BC	W 41-10	-14 W	U 54.5	CLEM -590
Oct 4th	@UNC	W 38-10	-15.5 W	O 47.5	CLEM -720
Sep 20th	SYR	L 21-34	-17.5 L	O 53.5	SYR -900
Sep 13th	@GT	L 21-24	-3 L	U 50.5	GT -145

Duke

Total

Clemson

439

Total Yards

560

Total Plays

6.859375

Yards Per Play

7.777777777777778

Duke

Passing

Clemson

361

YDS

385

27/42

Comps/Atts

27/36

8.595238095238095

YPA

10.694444444444445

4/0

TDs/INTs

2/0

2/15

Sacks/Yards

1/6

Duke

Rushing

Clemson

Rush Yards

175

Attempts

3.5454545454545454

YPC

4.861111111111111

TDs

Duke

Turnovers

Clemson

Fumbles Lost

Interceptions

Duke

Efficiency

Clemson

4/4 100%

Redzone

6/6 100%

3/14 0%

3rd Down

3/10 0%

5/5 0%

4th Down

3/3 0%

Duke

First Downs

Clemson

Total

Pass

Rush

Penalty

Duke

Misc

Clemson

9/62

Penalties/Yards

8/87

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See more NCAAF Odds

MatchupOverUnder
Duke 5-5	o25-111	u25-114
Clemson 5-5	o29.5-110	u29.5-115

Duke vs. Clemson Odds & Betting Predictions - November 1, 2025

Duke at Clemson

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Duke at Clemson Odds

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Prop Odds Comparison

Line Movement Tracker

Duke vs. Clemson Public Betting Percentages

Duke

Public

Clemson

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Duke vs. Clemson Odds Comparison

Duke at Clemson Team Totals