Louisville vs. Duke Odds & Betting Predictions - January 27, 2026

Louisville at Duke

12:00 am • ESPN
52 - 83

Louisville at Duke Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Louisville
19-6
N/A
N/A
N/A
Duke
23-2
N/A
N/A
N/A
location pinTuesday 12:00 a.m.
January 27, 2026
Cameron Indoor StadiumDurham
Louisville vs. Duke Expert Picks
Scott Rickenbach
Scott Rickenbach
Last 30d: 103-108-1 (-18.2u)
LOU +8.5-105
1u
FTN Fantasy
FTN Fantasy
Last 30d: 171-186-2 (-36.6u)
LOU +8.5-105
1u
Mike McNamara
Mike McNamara
Last 30d: 72-90-1 (-1.0u)
LOU +8.5-112
0.28u
Ryan Minion
Ryan Minion
Last 30d: 221-230-3 (+66.1u)
LOU +8.5-110
$1.10
ADD 0.5u (# Play)
Babs .
Babs .
Last 30d: 34-27-0 (+4.6u)
LOU +8.5-105
1u
Ryan Minion
Ryan Minion
Last 30d: 221-230-3 (+66.1u)
M.Brown o14.5 Pts-125
$1.25
Mjaybrod
Mjaybrod
Last 30d: 61-41-0 (+26.4u)
DUKE -8.5-105
0.95u
Fading the popular dog
Boomer Betz
Boomer Betz
Last 30d: 73-76-2 (-11.9u)
LOU +8.5-110
$55.00
Ryan Minion
Ryan Minion
Last 30d: 221-230-3 (+66.1u)
LOU +340
$0.20
0.2u (# stab)
Doug Ziefel
Doug Ziefel
Last 30d: 141-155-1 (+0.3u)
C.Boozer o9.5 Rebs-125
0.5u
LOU +8.5-110
0.55u
M.Brown o14.5 Pts-125
0.63u
💰🦡 Jake
💰🦡 Jake
Last 30d: 113-113-3 (+30.2u)
DUKE -7.5-110
1u
Three Man Weave
Three Man Weave
Last 30d: 18-21-0 (-4.8u)
DUKE -7.5-105
1u
Ryan Minion
Ryan Minion
Last 30d: 221-230-3 (+66.1u)
LOU +7.5-110
$1.10
Action ✍️ (ADD 1u) Mikel SZN!!
CTO
CTO
Last 30d: 20-21-0 (+4.4u)
LOU +7.5-110
2u
Stuck 🚨
Stuck 🚨
Last 30d: 55-57-2 (-1.1u)
LOU +7.5-110
0.3u
Mike Calabrese
Mike Calabrese
Last 30d: 55-51-2 (+9.0u)
LOU +7.5-110
1.1u
I wanted to target game two of Mikel Brown’s return
Ryan Minion
Ryan Minion
Last 30d: 221-230-3 (+66.1u)
LOU +225
$1.00
ACTION ✍️
Boomer Betz
Boomer Betz
Last 30d: 73-76-2 (-11.9u)
LOU +6.5-110
$110.00
Ryan Minion
Ryan Minion
Last 30d: 221-230-3 (+66.1u)
LOU +7-120
$1.20
ACTION ✍️

Louisville vs. Duke Previews & Analysis

  • Louisville vs Duke: Back at Full Strength article feature image

    Louisville vs Duke: Back at Full Strength

    Ryan Minion
    Jan 26, 2026 UTC
  • 3MW's 3 NCAAB Best Bets for Monday article feature image

    3MW's 3 NCAAB Best Bets for Monday

    Matt Cox
    Jan 26, 2026 UTC
  • How to Bet 2 Ranked NCAAB Big Monday Matchups article feature image

    How to Bet 2 Ranked NCAAB Big Monday Matchups

    Action Network Staff
    Jan 26, 2026 UTC
See more NCAAB Coverage Right Arrow

Prop Odds Comparison

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Line Movement Tracker

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Louisville vs. Duke Public Betting Percentages

Away Logo

Louisville

Public

50%

Bets%

50%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Duke
13-127-96-310-10N/A
Louisville
13-128-75-510-70-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Duke
7-185-112-75-15N/A
Louisville
9-165-104-67-100-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Duke
23-2N/AN/A18-2N/A
Louisville
19-6N/AN/A14-30-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jan 24thWAKEW 90-69---
Jan 17th@STANW 80-50-11.5 WU 148.5DUKE -750
Jan 15th@CALW 71-56-14.5 WU 149.5DUKE -1233
Jan 10thSMUW 82-75-15.5 LO 156.5DUKE -1465
Jan 7th@LOUW 84-73-1.5 WU 161.5DUKE -112

Duke vs. Louisville Injury Updates

Duke Injuries

  • Ifeanyi Ufochukwu
    C

    Ufochukwu is out with undisclosed

    Out

Louisville Injuries

    Team Stats
    16-54 (30%)
    Field Goals
    31-61 (51%)
    9-13 (69%)
    Free Throws
    13-18 (72%)
    11-34 (32%)
    3P
    8-23 (35%)
    21
    Rebounds
    44
    11
    Assists
    14
    12
    Turnovers
    10
    6
    Steals
    7
    3
    Blocks
    1
    17
    Fouls
    12

    Louisville vs. Duke Odds Comparison

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    Louisville at Duke Team Totals

    MatchupOverUnder
    Louisville
    19-6
    N/A
    N/A
    Duke
    23-2
    N/A
    N/A