Louisville vs. Duke Odds & Betting Predictions - January 27, 2026

Louisville at Duke

12:00 am • ESPN

Louisville Cardinals

Duke Blue Devils

MatchupOpenSpreadTotalMoneyline
Louisville 14-5	+4.5	+7.5-110	o157.5-105	+245
Duke 18-1	u163.5	-7.5-110	u157.5-115	-305

Tuesday 12:00 a.m.

January 27, 2026

Cameron Indoor StadiumDurham

LOU +7.5-110

1.1u

I wanted to target game two of Mikel Brown’s return

LOU +225

$1.00

ACTION ✍️

LOU +6.5-110

$110.00

LOU +7-120

$1.20

ACTION ✍️

No props found

NCAAB Public Betting

Duke are 5-0 in their last 5 games.
Duke are 4-1 in their last 5 games against the spread
Duke are 5-1 in their road games against the spread
The totals have gone OVER in 2 of Duke' last 5 games
The totals have gone OVER in 5 of Duke' 13 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Duke	11-8	6-7	5-1	8-6	N/A
Louisville	10-9	6-6	4-3	7-5	0-2

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Duke	7-12	5-8	2-4	5-9	N/A
Louisville	7-12	4-8	3-4	5-7	0-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Duke	18-1	N/A	N/A	13-1	N/A
Louisville	14-5	N/A	N/A	9-3	0-2

date	opponent	score	spread	over/under	moneyline
Jan 24th	WAKE	W 90-69	-	-	-
Jan 17th	@STAN	W 80-50	-11.5 W	U 148.5	DUKE -750
Jan 15th	@CAL	W 71-56	-14.5 W	U 149.5	DUKE -1233
Jan 10th	SMU	W 82-75	-15.5 L	O 156.5	DUKE -1465
Jan 7th	@LOU	W 84-73	-1.5 W	U 161.5	DUKE -112

Spencer Legg
G
Legg is questionable with undisclosed
Questionable
Khani Rooths
F
Rooths is questionable with illness
Questionable

Ifeanyi Ufochukwu
C
Ufochukwu is questionable with knee
Questionable

See more NCAAB Injuries

Louisville

Duke

29-62 (47%)

Field Goals

29-58 (50%)

16-21 (76%)

Free Throws

18-25 (72%)

11-33 (33%)

9-26 (35%)

Rebounds

37.42

17.8

Assists

17.5

11.32

Turnovers

11.21

7.32

Steals

8.53

3.32

Blocks

4.05

19.26

Fouls

16.58

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See more NCAAB Odds

MatchupOverUnder
Louisville 14-5	N/A	N/A
Duke 18-1	N/A	N/A

Louisville vs. Duke Odds & Betting Predictions - January 27, 2026

Louisville at Duke

Louisville Cardinals

Duke Blue Devils

Louisville at Duke Odds

Spread, Total, Moneyline

Prop Odds Comparison

Line Movement Tracker

Louisville vs. Duke Public Betting Percentages

Louisville

Public

Duke

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Louisville vs. Duke Injury Updates

Louisville Injuries

Duke Injuries

Louisville vs. Duke Odds Comparison

Louisville at Duke Team Totals