White Sox vs. Guardians Odds & Betting Predictions - September 12, 2025

White Sox at Guardians

11:10 pm • CLEG

Chicago White Sox

0-0

0 - 4

Cleveland Guardians

1-2

pitcher		team	era	w-l
T.Bibee			4.25	12-11
M.Perez			3.54	1-6

MatchupOpenSpreadTotalMoneyline
White Sox 0-0	+1.5-180	o7.5-110	+119
Guardians 1-2	u8	-1.5+150	u7.5-108	-142

Friday 11:10 p.m.

September 12, 2025

Progressive FieldCleveland

CLE -135

0.5u

I actually don’t consider Martin Perez a gas can but project Cleveland for half a run higher and like how the Cleveland bats profile against him.

Under 7.5-103

1.21u

CLE -139

0.72u

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T.Bibee u5.5 Ks-145

@cowhitchurch https://myaction.app/RW4DhImIBWb

CWS +135

CLE -146

0.5u

Bet to -155

White Sox vs Guardians: Tonight's Over/Under Pick
Action Network Staff•
Sep 12, 2025 UTC

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No props found

MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 1-4 in their last 5 games against the spread
Guardians are 47-34 in their road games against the spread
The totals have gone OVER in 2 of Guardians' last 5 games
The totals have gone OVER in 37 of Guardians' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	86-76	39-42	47-34	33-36	51-38
White Sox	94-68	47-34	47-34	0-2	92-66

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	69-87-6	37-41-3	32-46-3	34-34-1	34-50-5
White Sox	75-80-7	42-34-5	33-46-2	0-2	73-78-7

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	88-74	45-36	43-38	44-25	43-46
White Sox	60-102	33-48	27-54	1-1	58-100

date	opponent	score	spread	over/under	moneyline
Sep 11th	KC	W 3-2	-	-	CLE -144
Sep 10th	KC	L 3-4	+1.5 W	U 8	KC -110
Sep 9th	KC	W 2-0	+1.5 W	U 7.5	CLE -110
Sep 8th	KC	W 10-2	+1.5 W	O 7.5	CLE -115
Sep 7th	@TB	W 2-1	+1.5 W	U 8	CLE +138

Ky Bush
SP
Bush is out with elbow
Out
Drew Thorpe
SP
Thorpe is out with elbow
Out

See more MLB Injuries

PITCHER		PC	IP	K	ER
LM.Perez, P		96	6.2	3	3
RS.Wilson, P		23	1.1	0	1

HITTERS	H-AB	R	HR	RBI
1M.Tauchman, RF	0-4	0	0	0
2K.Teel, C	0-4	0	0	0
3L.Sosa, 1B	0-4	0	0	0
4C.Montgomery, SS	0-3	0	0	0
5M.Vargas, 3B	0-3	0	0	0
6A.Benintendi, DH	0-3	0	0	0
7B.Baldwin, CF	0-2	0	0	0
7M.Taylor, CF	0-1	0	0	0
8C.Meidroth, 2B	1-3	0	0	0
9W.Robertson, LF	1-2	0	0	0

PITCHER		PC	IP	K	ER
RT.Bibee, P		103	9	10	0

HITTERS	H-AB	R	HR	RBI
1S.Kwan, LF	0-3	0	0	0
2A.Martinez, CF	1-3	1	1	1
3J.Ramirez, 3B	0-4	0	0	0
4D.Fry, DH	1-3	1	1	1
5K.Manzardo, 1B	0-3	0	0	0
6G.Arias, SS	1-3	1	0	0
7J.Noel, RF	1-2	1	0	0
7N.Jones, PH	1-1	0	0	1
7N.Jones, RF	1-1	0	0	1
8B.Rocchio, 2B	0-3	0	0	0
9A.Hedges, C	1-3	0	0	1