Padres vs. Mariners Odds & Betting Predictions - May 16, 2026

Padres at Mariners

1:40 am • SEAM

San Diego Padres

Seattle Mariners

pitcher		team	era	w-l
E.Hancock			3.21	3-1
R.Vasquez			3.05	4-1

MatchupOpenSpreadTotalMoneyline
Padres 25-18	+1.5	+1.5-200	o7-115	+110
Mariners 22-23	u7.5	-1.5+165	u7-105	-133

Saturday 1:40 a.m.

May 16, 2026

T-Mobile ParkSeattle

53°Fahrenheit

0%Rain

10Wind

SD +110

SD +123 (F5)

0.53u

#EV 1.29%

Under 7.5-122

1.22u

SD +115

Join Discord for earlier access: https://discord.gg/HjKxYKdSUy San Diego is 25-18 against a 22-23 Seattle team, and the plus price is too generous for that gap. Randy Vasquez has a 3.05 ERA and has allowed only 4 home runs in 8 starts. Seattle is missing Cal Raleigh on the 10-Day-IL, which trims a key bat from the catcher spot.

R.Vasquez o1.5 BB-130

1.3u

E.Hancock o5.5 Ks+144

0.81u

#EV

E.Hancock o4.5 Ks-155

1.55u

Under 7.5-112

0.56u

Bet to 7 (-105)

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No props found

MLB Public Betting

Mariners are 3-2 in their last 5 games.
Mariners are 3-2 in their last 5 games against the spread
Mariners are 8-14 in their road games against the spread
The totals have gone OVER in 2 of Mariners' last 5 games
The totals have gone OVER in 11 of Mariners' 23 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Mariners	17-28	9-14	8-14	16-26	1-2
Padres	23-20	13-10	10-10	13-12	10-8

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Mariners	19-24-2	11-11-1	8-13-1	19-21-2	0-3
Padres	18-24-1	10-12-1	8-12	9-15-1	9-9

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Mariners	22-23	12-11	10-12	21-21	1-2
Padres	25-18	13-10	12-8	15-10	10-8

date	opponent	score	spread	over/under	moneyline
May 14th	@HOU	W 8-3	-1.5 W	O 9	SEA -115
May 14th	@HOU	L 3-4	-1.5 L	U 9	HOU -136
May 13th	@HOU	W 10-2	-1.5 W	O 9	SEA -202
May 12th	@HOU	W 3-1	-1.5 W	U 8.5	SEA -155
May 10th	@CWS	L 1-2	-1.5 L	U 8	CWS -138

Miles Mastrobuoni
3B
Mastrobuoni is out with calf
Out
Bryce Miller
SP
Miller is out with oblique
Out

Joe Musgrove
SP
Musgrove is out with elbow
Out
Will Wagner
3B
Wagner is out with oblique
Out

See more MLB Injuries

PITCHER		W-L	ERA	WHIP	K/9
RR.Vasquez, P		4-1	3.04	1.173	8.53

HITTERS	AVG	OBP	SLG	HR
1J.Merrill, CF	.215	.287	.342	4
2F.Tatis, 2B	.244	.318	.288	0
3M.Machado, 3B	.190	.287	.340	6
4M.Andujar, DH	.289	.314	.482	3
5X.Bogaerts, SS	.257	.331	.414	7
6G.Sheets, 1B	.229	.289	.458	6
7N.Castellanos, RF	.200	.233	.329	2
8R.Laureano, LF	.214	.296	.379	5
9F.Fermin, C	.176	.267	.230	0

PITCHER		W-L	ERA	WHIP	K/9
RE.Hancock, P		3-1	3.21	1.007	9.44

HITTERS	AVG	OBP	SLG	HR
1B.Donovan, 3B	.278	.396	.468	3
2J.Rodriguez, CF	.261	.325	.428	7
3J.Naylor, 1B	.247	.311	.367	5
4R.Arozarena, LF	.301	.389	.454	4
5L.Raley, RF	.268	.333	.589	10
6J.Crawford, SS	.215	.363	.362	5
7D.Canzone, DH	.253	.320	.462	4
8M.Garver, C	.176	.354	.255	1
9C.Young, 2B	.248	.328	.363	3