Guardians vs. White Sox Odds & Betting Predictions - June 22, 2026

Guardians at White Sox

11:40 pm • CHSN

Cleveland Guardians

41-38

5 - 6

Chicago White Sox

40-37

pitcher		team	era	w-l
A.Kay			4.25	6-2
G.Williams			3.82	9-4

MatchupOpenSpreadTotalMoneyline
Guardians 41-38	-1.5	-1.5+151	o7.5-102	-110
White Sox 40-37	u7.5	+1.5-183	u7.5-119	-108

Monday 11:40 p.m.

June 22, 2026

Rate FieldChicago

CWS +145 (Live)

1.45u

CWS +100 (F5)

0.5u

(FD) Williams about a run better than Kay for the season, but over L30 days closer to 1/2 run (same xwOBA against) - CLE LU 67 wRC+ v LHP/93 L30 days, CWS 103/119 - CWS def 12 FRV edge (Teel back)

Over 7.5+100

1.5u

Under 7.5+100

0.5u

Bet to -110

CLE o3.5-125

A.Kay u2.5 BB-135

Under 4 (F5)-110

0.91u

CLE -115

1.15u

The Leadoff: Anderson's MLB Breakdown and Bets for Monday
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Jun 22, 2026 UTC
Guardians vs White Sox: An Edge on a Hidden Trend
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No props found

MLB Public Betting

White Sox are 2-3 in their last 5 games.
White Sox are 3-2 in their last 5 games against the spread
White Sox are 19-21 in their road games against the spread
The totals have gone OVER in 2 of White Sox' last 5 games
The totals have gone OVER in 21 of White Sox' 37 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
White Sox	44-33	25-12	19-21	7-5	36-28
Guardians	42-37	19-17	23-20	18-23	24-13

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
White Sox	45-31-1	21-15-1	24-16	6-5-1	38-26
Guardians	39-40	18-18	21-22	21-20	17-20

Straight-Up (ML) History

	overall	home	away	favorite	underdog
White Sox	40-37	25-12	15-25	8-4	31-33
Guardians	41-38	19-17	22-21	22-19	19-18

date	opponent	score	spread	over/under	moneyline
Jun 21st	@DET	L 4-5	-1.5 L	O 8.5	DET +100
Jun 20th	@DET	L 1-4	+1.5 L	U 9	DET +104
Jun 19th	@DET	L 3-4	+1.5 W	U 8.5	DET +168
Jun 18th	@NYY	W 5-1	+1.5 W	U 10	CWS +145
Jun 17th	@NYY	L 5-10	+1.5 L	O 8.5	NYY +148

Mike Vasil
RP
Vasil is out with elbow
Out
Ky Bush
SP
Bush is out with elbow
Out
Brooks Baldwin
LF
Baldwin is out with elbow
Out
Drew Thorpe
SP
Thorpe is out with elbow
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RG.Williams, P	95	5	8	2
LT.Herrin, P	16	1	1	1
RS.Armstrong, P	14	1	1	1
RC.Smith, P	28	1.2	3	2

HITTERS	H-AB	R	RBI
1T.Bazzana, 2B	1-3	2	0
2D.Fry, LF	0-2	0	0
2K.Watson, PH	1-1	0	2
2P.Bailey, C	1-1	1	1
3B.Rocchio, SS	3-5	0	0
4R.Hoskins, 1B	1-4	0	1
5K.Manzardo, DH	0-3	0	1
6G.Arias, 3B	0-5	0	0
7S.Fairchild, RF	0-2	0	0
7S.Kwan, PH	0-0	1	0
7S.Kwan, LF	0-0	1	0
8A.Hedges, C	0-2	0	0
8D.Schneemann, PH	1-2	1	0
8D.Schneemann, CF	1-2	1	0
9P.Halpin, CF	0-4	0	0
9P.Halpin, RF	0-4	0	0

PITCHER	PC	IP	K	ER
LA.Kay, P	101	6	8	0
RG.Taylor, P	30	0.2	2	3
LB.Hudson, P	23	1.1	3	0
RS.Dominguez, P	22	0.1	1	2
LC.Murphy, P	6	0.2	1	0

HITTERS	H-AB	R	HR	RBI
1S.Antonacci, LF	2-4	1	0	3
2M.Vargas, 1B	1-4	0	0	0
3A.Benintendi, DH	1-2	0	0	1
3R.Grichuk, PH	1-2	1	1	1
3R.Grichuk, DH	1-2	1	1	1
4K.Teel, C	0-4	0	0	0
5C.Montgomery, 3B	0-4	0	0	0
6C.Meidroth, 2B	1-4	1	0	0
7B.Montgomery, RF	2-3	2	0	1
8T.Peters, CF	1-4	1	0	0
9L.Acuna, SS	1-3	0	0	0
9J.Gonzalez, PH	0-1	0	0	0