Guardians vs. Red Sox Odds & Betting Predictions - September 1, 2025

Guardians at Red Sox

5:35 pm • CLEG
4 - 6
Starting Pitchers
pitcherteameraw-l
Brayan Bello logoB.BelloBoston Red Sox logo3.3511-9
Parker Messick logoP.MessickCleveland Guardians logo2.723-1

Guardians at Red Sox Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Guardians
1-2
+1.5
+1.5-168
o8-116
+122
Red Sox
1-2
u8.5
-1.5+142
u8-106
-146
location pinMonday 5:35 p.m.
September 01, 2025
Fenway ParkBoston
Guardians vs. Red Sox Expert Picks
Austin Pendergrass
Austin Pendergrass
Last 30d: 47-47-0 (-1.2u)
BOS -132 (Live)
0.38u
Sir Lockselot
Sir Lockselot
Last 30d: 30-60-0 (-26.7u)
CLE +122
2u
📚Player Profit 🔑 Guardians ML +122 (Player Profit) 2u I’m backing the Guardians moneyline today at +122 because while the Red Sox are modest favorites, Cleveland has shown surprising resilience as a road underdog. They’ve won more than half their games when listed as underdogs (+122 or longer) and have gone 4–1 recently. These odds offer value—Boston’s ~59% win probability overlooks the Guardians’ ability to stay competitive and produce upsets, making the +122 line a smart value play. Code: airlocks for 10% off at playerprofit.com
The Propfessor
The Propfessor
Last 30d: 35-52-2 (+4.5u)
P.Messick o15.5 Outs-115
1u
Austin Pendergrass
Austin Pendergrass
Last 30d: 47-47-0 (-1.2u)
Under 4.5 (F5)-122
0.5u
Player Prop Savant
Player Prop Savant
Last 30d: 30-24-0 (+2.6u)
B.Bello u2.5 Earned Runs-130
1.3u
Allan Lem
Allan Lem
Last 30d: 118-116-8 (-4.6u)
Under 8.5-105
0.53u
Sean Zerillo
Sean Zerillo
Last 30d: 155-181-6 (-9.3u)
CLE +135
0.5u
Bet to +125

Guardians vs. Red Sox Previews & Analysis

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Prop Odds Comparison

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Line Movement Tracker

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Guardians vs. Red Sox Public Betting Percentages

Away Logo

Guardians

Public

17%

Bets%

83%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Red Sox
87-7543-3844-3753-5034-23
Guardians
86-7639-4247-3433-3651-38

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Red Sox
76-82-433-45-343-37-150-50-326-30-1
Guardians
69-87-637-41-332-46-334-34-134-50-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Red Sox
89-7348-3341-4061-4228-29
Guardians
88-7445-3643-3844-2543-46

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 31stPITW 5-2-1.5 WU 8.5BOS -175
Aug 30thPITL 3-10-1.5 LO 9PIT -188
Aug 29thPITL 2-4+1.5 LU 8PIT -118
Aug 28th@BALW 3-2-1.5 LU 8BOS -204
Aug 27th@BALW 3-2-1.5 LU 9BOS -139

Guardians vs. Red Sox Injury Updates

Guardians Injuries

  • Edward Lively
    SP

    Lively is out with elbow

    Out

  • John Means
    SP

    Means is out with elbow

    Out

Red Sox Injuries

  • Jose De Leon
    RP

    De Leon is out with elbow

    Out

  • Tanner Houck
    SP

    Houck is out with arm

    Out

  • Patrick Sandoval
    SP

    Sandoval is out with elbow

    Out

  • Kutter Crawford
    SP

    Crawford is out with knee

    Out

  • Jovani Moran
    RP

    Moran is out with arm

    Out

Guardians vs. Red Sox Box Score
Guardians Player Stats
Projected
PITCHERPCIPKER
Parker Messick logoLP.Messick, P823.223
Matthew Festa logoRM.Festa, P100.110
Erik Sabrowski logoLE.Sabrowski, P220.112
Jakob Junis logoRJ.Junis, P151.211
Zachary Kent logoRZ.Kent, P37210
HITTERSH-ABRHRRBI
Steven Kwan logo1S.Kwan, LF3-5000
Daniel Schneemann logo2D.Schneemann, 2B0-3000
Jose Ramirez logo3J.Ramirez, 3B0-4000
Kyle Manzardo logo4K.Manzardo, 1B1-4111
Noah Naylor logo5B.Naylor, C1-3100
Nolan Jones logo6N.Jones, CF1-4100
George Valera logo7G.Valera, DH0-1100
David Fry logo7D.Fry, PH0-2000
David Fry logo7D.Fry, DH0-2000
CJ Kayfus logo8C.Kayfus, RF1-2001
Jhonkensy Noel logo8J.Noel, PH0-2000
Jhonkensy Noel logo8J.Noel, RF0-2000
Brayan Rocchio logo9B.Rocchio, SS1-4002
Red Sox Player Stats
Projected
PITCHERPCIPKER
Brayan Bello logoRB.Bello, P100543
Justin Wilson logoLJ.Wilson, P6100
Steven Matz logoLS.Matz, P231.211
Gregory Weissert logoRG.Weissert, P20.100
Albertin Chapman logoLA.Chapman, P5110
HITTERSH-ABRHRRBI
Roman Anthony logo1R.Anthony, RF2-5100
Alexander Bregman logo2A.Bregman, 3B1-5100
Trevor Story logo3T.Story, SS3-4112
Roman Gonzalez logo4R.Gonzalez, 2B2-5001
Roman Gonzalez logo4R.Gonzalez, 1B2-5001
Robert Refsnyder logo5R.Refsnyder, DH2-5100
Nathan Eaton logo6N.Eaton, LF2-3100
Jarren Duran logo6J.Duran, PH0-1000
Jarren Duran logo6J.Duran, LF0-1000
Ceddanne Rafaela logo7C.Rafaela, CF0-3000
David Lowe logo8N.Lowe, 1B0-2000
Carlos Narvaez logo8C.Narvaez, PH1-1002
David Hamilton logo8D.Hamilton, PR0-0000
David Hamilton logo8D.Hamilton, 2B0-0000
Connor Wong logo9C.Wong, C1-2100

Guardians vs. Red Sox Odds Comparison

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Guardians at Red Sox Team Totals

MatchupOverUnder
Guardians
1-2
o3.5-120
u3.5-108
Red Sox
1-2
o4.5+112
u4.5-143