Giants vs. Padres Odds & Betting Predictions - August 21, 2025
Giants at Padres
8:10 pm • SDPAStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
![]() | 4.55 | 8-12 | ||
![]() | 3.85 | 4-11 |
Giants at Padres Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Giants 0-0 | +1.5 | +1.5-134 | o8-111 | +161 |
Padres 1-2 | u8 | -1.5+109 | u8-111 | -193 |

PETCO ParkSan Diego
Giants vs. Padres Expert Picks
Cam Is Money
Last 30d: 73-94-3 (-15.7u)
SF +164
0.5u
Picks Office
Last 30d: 108-91-3 (+10.7u)
Over 7.5-120
0.83u
SD -1.5+130
1.3u
YBK Picks.com
Last 30d: 67-34-3 (+61.0u)
SD -1.5+115
2.3u
💰🦡 Jake
Last 30d: 116-129-6 (+3.8u)
Under 0.5 (1st Inn)-120
1u
Allan Lem
Last 30d: 128-108-5 (+0.8u)
Under 8-118
0.59u
Under is popping in the Action models so I’ll bite
The Pick Don
Last 30d: 18-10-0 (+10.1u)
Under 8-118
0.59u

Sean Zerillo
Last 30d: 102-128-5 (+1.8u)
Under 8-110
0.55u
Bet to -115
SD -150 (F5)
0.25u
Small to -165
Giants vs. Padres Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Giants vs. Padres Public Betting Percentages
Betting Trends
- Padres are 4-1 in their last 5 games.
- Padres are 4-1 in their last 5 games against the spread
- Padres are 42-39 in their road games against the spread
- The totals have gone OVER in 2 of Padres' last 5 games
- The totals have gone OVER in 34 of Padres' 81 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Giants vs. Padres Injury Updates

Giants Injuries
- Tom MurphyC
Murphy is out with back
Out
- JT BrubakerRP
Brubaker is out with ribs
Out

Padres Injuries
- Joe MusgroveSP
Musgrove is out for season with elbow
Out for Season
Giants vs. Padres Box Score
Giants Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
![]() | 91 | 4.1 | 4 | 7 | |
![]() | 17 | 0.2 | 1 | 1 | |
![]() | 32 | 2 | 1 | 0 | |
![]() | 10 | 1 | 1 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
![]() | 1-3 | 0 | 0 | 0 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 1-4 | 1 | 1 | 1 |
![]() | 1-2 | 1 | 1 | 1 |
![]() | 0-3 | 0 | 0 | 0 |
![]() | 0-1 | 0 | 0 | 0 |
![]() | 0-1 | 0 | 0 | 0 |
![]() | 1-3 | 0 | 0 | 0 |
![]() | 0-4 | 0 | 0 | 0 |
![]() | 2-4 | 1 | 0 | 0 |
![]() | 1-3 | 1 | 0 | 1 |
![]() | 0-1 | 0 | 0 | 0 |
Padres Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
![]() | 95 | 5 | 7 | 4 | |
![]() | 24 | 1.1 | 1 | 0 | |
![]() | 14 | 1 | 0 | 0 | |
![]() | 5 | 0.2 | 1 | 0 | |
![]() | 13 | 1 | 2 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
![]() | 2-5 | 2 | 0 | 0 |
![]() | 2-4 | 1 | 0 | 0 |
![]() | 2-4 | 1 | 0 | 3 |
![]() | 0-2 | 1 | 0 | 0 |
![]() | 1-3 | 0 | 0 | 2 |
![]() | 0-3 | 0 | 0 | 0 |
![]() | 1-1 | 0 | 0 | 0 |
![]() | 2-4 | 1 | 0 | 1 |
![]() | 2-4 | 1 | 0 | 1 |
![]() | 0-3 | 1 | 0 | 0 |
![]() | 1-4 | 1 | 0 | 0 |
Giants vs. Padres Odds Comparison
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Giants at Padres Team Totals
MatchupOverUnder | ||
|---|---|---|
Giants 0-0 | o3.5+110 | u3.5-140 |
Padres 1-2 | o4.5+101 | u4.5-130 |
































