The San Diego Padres host the Los Angeles Dodgers on August 23, 2025. First pitch from PETCO Park is scheduled for 8:40 p.m. EDT; the game will be broadcast on Fox Sports 1.
Find my MLB betting preview and Dodgers vs Padres prediction below, as well as probable pitchers, betting trends, injury reports, and more.
My Dodgers vs Padres Prediction
- Dodgers vs Padres pick: Dodgers F5 -0.5 (-105)
My Dodgers vs Padres best bet is the Dodgers' first five run line. Make sure to find the best odds by checking our live MLB odds page.
Dodgers vs Padres Odds, Spread, Best Bet
| San Francisco Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -131 | 8 -103o / -118u | +162 |
| San Diego Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +108 | 8 -103o / -118u | -194 |
Dodgers vs Padres Run Line: Dodgers +1.5 (-131); Padres -1.5 (+108)
Dodgers vs Padres Totals: 8 (O -103 / U -118)
Dodgers vs Padres Moneyline: Dodgers +162; Padres -194
Dodgers vs Padres Best Bet: Dodgers F5 -0.5 (-105)
Dodgers vs Padres Projected Starting Pitchers
| Tyler Glasnow (LAD) | Stat | Nestor Cortes (SDP) |
|---|---|---|
| 1-1 | W-L | 1-2 |
| 0.8 | fWAR (FanGraphs) | -0.6 |
| 3.12 / 3.27 | ERA / xERA | 5.87 / 5.55 |
| 4.16 / 3.42 | FIP / xFIP | 8.51 / 5.80 |
| 1.14 | WHIP | 1.65 |
| 18.7 | K-BB% | 6.6 |
| 47 | GB% | 34.3 |
| 100 | Stuff+ | 101 |
| 93 | Location+ | 85 |
Doug Ziefel’s Dodgers vs Padres Preview
Los Angeles Dodgers Betting Preview: Great Matchup Against Cortes
The Dodgers wound up on the wrong end of a pitcher's duel in last night's matchup, but tonight, they'll have a huge edge on the mound as they are set to face the Padres' Nestor Cortes.
San Diego acquired Cortes after an injury-riddled first half with Milwaukee, where he posted a 9.00 ERA in two starts. Well, things have not gone much better in his three starts with the Padres.
He comes in with a 4.20 ERA and 1.60 WHIP over his last three starts and has not shown any signs of improvement.
Cortes' command issues have put him behind the 8-ball as he's walked hitters and allowed a great deal of hard contact.
Those are not qualities you want to take into a start against a Dodgers' lineup that ranks first in BABIP and eighth in wRC+ and OPS over the last month.
San Diego Padres Betting Preview: One of the Hottest Lineups in MLB
As for the Padres, they come into this matchup riding high after yesterday's win, but they will need their lineup to step up and stay hot. San Diego has arguably been the hottest lineup in baseball over the last month.
The Padres rank first in batting average, OBP, and BABIP against righties in the last 30 days. However, tonight they are not facing just any right-hander as Tyler Glasnow will take the ball for Los Angeles.
Glasnow has had some blips with his control since returning from the injured list, but has also flashed elite swing and miss stuff. If his command is honed in tonight, he has the potential to shut down this Padres lineup.
Glasnow's xBA and strikeout rate sit in the 91st percentile. He profiles as the pitcher who can combat this high-contact lineup that the Padres roll out.
Dodgers vs Padres Prediction, Betting Analysis
While this series features two of the best lineups in the National League, there is a big discrepancy on the mound in this matchup.
Nestor Cortes has been a shell of his former self and does not have what it takes to navigate this dangerous Dodgers lineup multiple times. However, Glasnow does have what it takes to contain the Padres lineup, and he should only become more aggressive with early run support.
Back the Dodgers to be leading halfway through this one by taking them on the first five run line.
Pick: Dodgers F5 -0.5 (-105, BetMGM)
Moneyline
The Dodgers are the side here, but there are better ways to back them than on the moneyline.
Run Line (Spread)
Take the Dodgers to cover the first five run line.
Over/Under
I have no play on the total.
