Giants vs. Diamondbacks Odds & Betting Predictions - September 17, 2025

Giants at Diamondbacks

7:40 pm • MLB Network

San Francisco Giants

22-35

5 - 1

Arizona Diamondbacks

31-25

pitcher		team	era	w-l
B.Pfaadt			5.25	13-9
J.Verlander			3.85	4-11

MatchupOpenSpreadTotalMoneyline
Giants 22-35	-1.5	-1.5+153	o9-103	-104
Diamondbacks 31-25	u9	+1.5-189	u9-115	-116

Wednesday 7:40 p.m.

September 17, 2025

Chase FieldPhoenix

SF +120 (Live)

1.2u

ARI o4.5+112

R.Devers o1.5 Total Bases+105

$1.50

B.Pfaadt u5.5 Hits Allowed-113

0.5u

SF -110 (F5)

1.1u

J.Verlander o4.5 Ks-110

0.55u

SF -110 (F5)

1.1u

ARI -110

0.55u

Bet to -115

SF -120 (F5)

ARI -108 (F5)

1.08u

Pair of volatile pitchers matchup comparably - SFG 50 wRC+ L7 days - ARI much better defense and base running.

Giants vs Diamondbacks: A Flurry of Runs
Tony Sartori•
Sep 17, 2025 UTC
Today's MLB Best Bets
Action Network Staff•
Sep 17, 2025 UTC

See more MLB Coverage

No props found

MLB Public Betting

Diamondbacks are 3-2 in their last 5 games.
Diamondbacks are 3-2 in their last 5 games against the spread
Diamondbacks are 17-12 in their road games against the spread
The totals have gone OVER in 2 of Diamondbacks' last 5 games
The totals have gone OVER in 12 of Diamondbacks' 28 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Diamondbacks	34-23	17-11	17-12	14-11	19-12
Giants	23-35	12-16	11-19	7-14	16-20

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Diamondbacks	28-26-3	12-15-1	16-11-2	10-14-1	17-12-2
Giants	27-27-4	14-12-2	13-15-2	14-5-2	12-22-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Diamondbacks	31-26	18-10	13-16	17-8	13-18
Giants	22-36	12-16	10-20	9-12	13-23

date	opponent	score	spread	over/under	moneyline
Sep 17th	SF	W 6-5	-1.5 L	O 9.5	ARI -134
Sep 16th	SF	W 8-1	-1.5 W	U 9	ARI -132
Sep 14th	@MIN	W 6-4	+1.5 W	O 9.5	ARI +104
Sep 13th	@MIN	W 5-2	+1.5 W	U 8.5	ARI +114
Sep 13th	@MIN	L 8-9	+1.5 W	O 8.5	MIN +120

Corbin Burnes
SP
Burnes is out with elbow
Out
Blake Walston
SP
Walston is out with elbow
Out
Tyler Locklear
1B
Locklear is out with elbow
Out

Cristian Mena
SP
Mena is doubtful with shoulder
Doubtful

Hayden Birdsong
SP
Birdsong is out with arm
Out

See more MLB Injuries

PITCHER	PC	IP	K
RJ.Verlander, P	107	7	3
RS.Bivens, P	8	1	0
RR.Walker, P	23	1	1
RJ.Peguero, P	26	2	1

HITTERS	H-AB	R	RBI
1H.Ramos, LF	0-4	0	0
1G.McCray, PR	0-0	0	1
1G.McCray, RF	0-0	0	1
2R.Devers, 1B	1-5	0	1
3W.Adames, SS	0-4	0	0
4M.Chapman, 3B	0-4	1	0
5B.Eldridge, DH	0-3	0	0
5J.Lee, PR	0-0	1	0
5J.Lee, DH	0-0	1	0
6J.Encarnacion, RF	1-4	1	1
6J.Encarnacion, LF	1-4	1	1
7P.Bailey, C	1-4	1	0
8C.Koss, 2B	1-4	1	2
9D.Gilbert, CF	1-4	0	0

PITCHER	PC	IP	K	ER
RB.Pfaadt, P	97	9	7	0
LB.Garcia, P	17	1	2	0
RJ.Curtiss, P	12	0	0	4
RJ.Morillo, P	18	1	2	0

HITTERS	H-AB	R	RBI
1G.Perdomo, SS	1-5	1	0
2K.Marte, 2B	0-5	0	0
3C.Carroll, RF	1-3	0	1
4G.Moreno, DH	0-3	0	0
4G.Moreno, C	0-3	0	0
5B.Alexander, 3B	2-4	0	0
6J.McCann, C	0-3	0	0
6A.Del Castillo, PH	0-1	0	0
7A.Thomas, CF	0-4	0	0
8T.Tawa, 1B	0-2	0	0
9J.McCarthy, LF	0-4	0	0