Astros vs. White Sox Odds & Betting Predictions - May 4, 2025

Astros at White Sox

6:10 pm • CHSN

Houston Astros

16-23

4 - 5

Chicago White Sox

17-21

pitcher		team	era	w-l
B.Wilson			6.66	0-2
L.McCullers			6.51	2-5

MatchupOpenSpreadTotalMoneyline
Astros 16-23	-1.5	-1.5-105	o8.5-101	-180
White Sox 17-21	u8.5	+1.5-115	u8.5-120	+150

Sunday 6:10 p.m.

May 04, 2025

Rate FieldChicago

Under 8.5-105

Lance McCullers makes his season debut with elite ground ball stuff (50.4% GB%), perfect vs Sox offense hitting just .212 w/ 3.61 RPG. Even if rusty, he hands off to a bullpen with a 2.18 ERA and 1.00 WHIP — top-tier group that can protect any lead or tie late. Bryse Wilson has a 5.00 ERA/1.78 WHIP but faces an Astros lineup hitting just .223 on the road, scoring 3.57 RPG away. Despite recent form (.270 last 10), their road sample says otherwise. White Sox offense ranks near bottom in AVG, OBP (.292), and SLG (.329). Strike out too much (8.5 K/9), don’t walk (3.5 BB/9). Under is 22-10-3 in Astros road games, 8-2 in Sox Sunday games. Head-to-head: Under 6-2 last 8 in Chicago. All signs point to low scoring.

B.Wilson u2.5 Earned Runs-140

0.7u

This is simply a play on Bryse Wilson likely not having a full starter’s workload here. He built up to 58 pitches last outing and I think between 4-5 innings is the most likely outcome here. Have him projected for 2.1 earned runs over 4+ innings. In terms of matchup it helps there’s no Yordan Alvarez and Isaac Paredes. Astros have averaged 4 runs per game this season and have been a slightly below average offense (19th in runs and 16th in wRC+). Just need Wilson to give me 4-5 innings of 2-run ball here before getting pulled for the bullpen.

CWS +170

5.1u

CWS +160 (F5)

B.Wilson u2.5 Ks+135

0.37u

Under 8.5-114

1.5u

No props found

MLB Public Betting

White Sox are 1-4 in their last 5 games.
White Sox are 2-3 in their last 5 games against the spread
White Sox are 12-10 in their road games against the spread
The totals have gone OVER in 2 of White Sox' last 5 games
The totals have gone OVER in 8 of White Sox' 16 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
White Sox	20-18	8-8	12-10	2-3	18-15
Astros	16-23	8-11	8-12	4-11	12-11

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
White Sox	21-17	8-8	13-9	3-2	18-15
Astros	25-12-2	14-5	11-7-2	9-6	15-6-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
White Sox	17-21	7-9	10-12	2-3	15-18
Astros	16-23	9-10	7-13	5-10	11-12

date	opponent	score	spread	over/under	moneyline
May 3rd	HOU	L 3-8	+1.5 L	O 7.5	HOU +190
May 2nd	HOU	W 7-3	+1.5 W	O 8	CWS +187
May 1st	MIL	W 8-0	+1.5 W	U 9	CWS +136
Apr 30th	MIL	L 4-6	+1.5 L	O 7.5	MIL +133
Apr 29th	MIL	L 2-7	+1.5 L	O 8	MIL +210

Mike Vasil
RP
Vasil is out with elbow
Out
Ky Bush
SP
Bush is out with elbow
Out
Brooks Baldwin
LF
Baldwin is out with elbow
Out
Kyle Teel
C
Teel is out with hamstring
Out
Drew Thorpe
SP
Thorpe is out with elbow
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RL.McCullers, P	87	3.2	4	0
RT.Scott, P	3	0.1	0	0
RR.Gusto, P	27	0.2	0	0
LS.Okert, P	26	1	1	2
RK.Ort, P	7	0.1	0	0

HITTERS	H-AB	R	HR	RBI
1J.Pena, SS	1-4	0	0	0
2J.Altuve, LF	0-4	0	0	0
3C.Walker, 1B	2-4	1	0	0
4Y.Diaz, DH	1-3	0	0	0
5V.Caratini, C	0-3	1	0	0
6Z.Dezenzo, RF	2-3	2	1	2
7J.Meyers, CF	1-1	0	0	0
8B.Rodgers, 2B	1-3	0	0	0
9M.Dubon, 3B	1-3	0	0	2

PITCHER		PC	IP	K	ER
RB.Wilson, P		89	4.2	4	4
RM.Vasil, P		31	2.1	0	0

HITTERS	H-AB	R	RBI
1C.Meidroth, SS	0-2	1	0
2M.Vargas, 1B	1-4	0	0
3A.Benintendi, LF	0-3	1	0
3B.Baldwin, PH	0-1	0	0
3B.Baldwin, LF	0-1	0	0
4L.Robert, CF	2-3	2	1
5E.Quero, C	2-4	1	1
6A.Vaughn, DH	1-4	0	0
7J.Rojas, 3B	0-2	0	1
8L.Sosa, 2B	1-2	0	2
9J.Palacios, RF	0-0	0	0
9M.Taylor, PH	0-1	0	0
9M.Taylor, RF	0-1	0	0