Astros vs. Rays Odds & Betting Predictions - May 21, 2025

Astros at Rays

5:10 pm • FDSSUN

Houston Astros

60-45

4 - 8

Tampa Bay Rays

53-52

pitcher		team	era	w-l
T.Bradley			4.61	6-6
H.Brown			2.54	9-5

MatchupOpenSpreadTotalMoneyline
Astros 60-45	-1.5	-1.5+107	o8.5-112	-168
Rays 53-52	u9	+1.5-122	u8.5-110	+142

Wednesday 5:10 p.m.

May 21, 2025

George M. Steinbrenner FieldTampa

T.Bradley u17.5 Outs+120

Full writeup: https://www.actionnetwork.com/mlb/houston-astros-vs-tampa-bay-rays-prediction-pick-odds-wednesday-may-21-qs?utm_source=action_app&utm_medium=app&utm_campaign=article_share

HOU -1-130

HOU -148

1.48u

HOU -0.5 (F5)-105

1.05u

T.Bradley o1.5 BB-117

HOU -158 (F5)

H.Brown o6.5 Ks-106

1.06u

Took this on NoVig, but Action doesn't have them as a book to track yet.

I.Paredes o1.5 Hits + Runs + RBIs-120

0.83u

Under 0.5 (1st Inn)-120

1.2u

HOU -135

Rays stuck in a home rut – 3-13 in last 16 at George M. Steinbrenner Field. Taj Bradley shaky – 5 ER in 4 IP last start, 9.95 ERA in 3 career outings vs Astros. Bullpen collapse: 5.86 ERA last 3 games. Houston’s offense clicking – Altuve, Meyers heating up. Hunter Brown = lights out. 6-2, 1.43 ERA, 0.829 WHIP in ‘25. 2-0 vs Rays, 1.06 ERA career. 27.0 bullpen innings last 3 games, 1.00 ERA, 0.67 WHIP. Brown last 3 starts: 1.83 ERA, 0.813 WHIP. No signs of slowing. Rays can’t solve him. Offense won’t save them. Bradley has 5 HR allowed in 12.2 IP vs HOU. Rays scoring just 3.79 runs/game at home (24th in MLB). Astros had won 5 of 7 before Tuesday. Multiple analysts backing Houston. Dimers model leans Astros (55%). Too many signs to ignore.

TB +122

3.66u

H.Brown o6.5 Ks-132

0.25u

TB +123

0.62u

Bet to +108

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No props found

MLB Public Betting

Rays are 1-4 in their last 5 games.
Rays are 0-5 in their last 5 games against the spread
Rays are 26-20 in their road games against the spread
The totals have gone OVER in 2 of Rays' last 5 games
The totals have gone OVER in 24 of Rays' 59 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Rays	49-56	23-36	26-20	20-32	28-23
Astros	54-51	26-29	28-22	30-43	24-7

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Rays	42-59-4	24-32-3	18-27-1	19-30-3	22-28-1
Astros	44-56-5	23-32	21-24-5	34-38-1	9-18-4

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Rays	53-52	31-28	22-24	30-22	22-29
Astros	60-45	33-22	27-23	41-32	19-12

date	opponent	score	spread	over/under	moneyline
May 20th	HOU	W 3-2	-1.5 L	U 9	TB -135
May 19th	HOU	L 3-4	-1.5 L	U 9	HOU -144
May 18th	@MIA	L 1-5	-1.5 L	U 9	MIA -164
May 17th	@MIA	W 4-0	-1.5 W	U 8	TB -147
May 16th	@MIA	L 4-9	-1.5 L	O 8.5	MIA -126

Alex Faedo
RP
Faedo is out with shoulder
Out
Brandon Lowe
2B
Lowe is out with ankle
Out
Shane McClanahan
SP
McClanahan is out with triceps
Out
Richie Palacios
LF
Palacios is out with knee
Out

Jake Meyers
CF
Meyers is out with calf
Out
Cristian Javier
SP
Javier is out with elbow
Out
Jeremy Pena
SS
Pena is out with ribs
Out
Luis Garcia
SP
Garcia is out with elbow
Out
Pedro Leon
RF
Leon is out with knee
Out
J.P. France
SP
France is out with shoulder
Out
Hayden Wesneski
RP
Wesneski is out with elbow
Out
Spencer Arrighetti
SP
Arrighetti is out with thumb
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RH.Brown, P	91	5	4	5
LB.Sousa, P	25	2	3	0
RF.Whitley, P	33	0.2	1	3
LS.Okert, P	6	0.1	0	0

HITTERS	H-AB	R	HR	RBI
1J.Pena, SS	0-3	1	0	0
2I.Paredes, 3B	2-4	2	2	3
3J.Altuve, DH	0-3	0	0	0
4Y.Diaz, C	1-4	0	0	0
5C.Walker, 1B	1-4	0	0	0
6J.Meyers, CF	1-4	0	0	0
7C.Smith, RF	0-4	0	0	0
8B.Rodgers, 2B	0-3	0	0	0
8V.Caratini, PH	0-1	0	0	0
9M.Dubon, LF	2-2	1	1	1

PITCHER	PC	IP	K	ER
RT.Bradley, P	84	6	7	2
LG.Cleavinger, P	10	1	1	0
RE.Uceta, P	15	1	2	2
RP.Fairbanks, P	20	1	2	0

HITTERS	H-AB	R	HR	RBI
1Y.Diaz, DH	2-5	2	1	3
2J.Lowe, RF	2-4	1	1	1
3B.Lowe, 2B	1-4	1	1	1
4J.Aranda, 1B	1-5	1	0	1
5J.Caballero, SS	1-3	0	0	0
6C.Simpson, LF	1-4	0	0	1
7K.Misner, CF	0-2	1	0	0
8C.Mead, 3B	2-3	2	1	1
9B.Rortvedt, C	0-4	0	0	0