Eagles vs. Panthers Odds & Betting Predictions - October 4, 2025
Eagles at Panthers
4:00 pm • ACC NetworkEagles at Panthers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Eagles 2-10 | +3.5 | +6.5-115 | o54.5-115 | +194 |
Panthers 8-5 | u53.5 | -6.5-115 | u54.5-115 | -240 |

Acrisure StadiumPittsburgh
Eagles vs. Panthers Expert Picks
Doug Ziefel
Last 30d: 148-173-1 (-11.4u)
R.Harris Anytime TD Scorer Yes+180
0.28u
Road to CFB
Last 30d: 0-0-0 (+0.0u)
Under 59.5-112
1u
Top Shelf Action 🥃
Last 30d: 120-143-0 (-36.4u)
PITT -5.5-110
0.91u
🔪
Eagles vs. Panthers Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Eagles vs. Panthers Public Betting Percentages
Betting Trends
- Panthers are 3-2 in their last 5 games.
- Panthers are 3-2 in their last 5 games against the spread
- Panthers are 4-1 in their road games against the spread
- The totals have gone OVER in 2 of Panthers' last 5 games
- The totals have gone OVER in 5 of Panthers' 7 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Team Stats
189
YDS
331
14/30
Comps/Atts
32/45
6.3
YPA
7.355555555555555
1/1
TDs/INTs
4/0
2/22
Sacks/Yards
2/14
Eagles vs. Panthers Odds Comparison
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Eagles at Panthers Team Totals
MatchupOverUnder | ||
|---|---|---|
Eagles 2-10 | N/A | N/A |
Panthers 8-5 | N/A | N/A |






