The Boston Red Sox (9-14) host the New York Yankees (14-9) on April 22, 2026. First pitch from Fenway Park is scheduled for 6:45 p.m. EDT. The game will be broadcast on MLB Network.
The Yankees are favored by -134 on the moneyline and priced at +126 to cover the run-line (-1.5). The Red Sox are +114 on the moneyline and -152 to cover +1.5. The total is set at 7.5 runs (-115 / -105).
Find my MLB picks and Yankees vs Red Sox prediction below, as well as probable pitchers, weather report, and more.
Yankees vs Red Sox Predictions and Picks
- Yankees vs Red Sox Pick: Max Fried to Record a Win +145 (Bet365, Play to +135)
My Yankees vs Red Sox best bet is on Max Fried to record a win. Make sure to find the best odds by checking our live MLB odds page.
Yankees vs Red Sox Odds, Spread, Line
| Yankees Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +126 | 7.5 -115o / -105u | -134 |
| Red Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -152 | 7.5 -115o / -105u | +114 |
- Yankees vs Red Sox moneyline: Yankees -134, Red Sox +114
- Yankees vs Red Sox over/under: 7.5 (-115o/ -105u)
Yankees vs Red Sox Pitchers
| LHP Max Fried (NYY) | Stat | LHP Ranger Suarez (BOS) |
|---|---|---|
| 2-1 | W-L | 1-1 |
| 0.8 | fWAR (FanGraphs) | 0.4 |
| 2.97/2.27 | ERA / xERA | 3.22/4.58 |
| 3.05/4.10 | FIP / xFIP | 3.77/3.71 |
| 0.81 | WHIP | 1.07 |
| 11.8% | K-BB% | 10.5% |
| 45.2% | GB% | 43.1% |
| 105 | Stuff+ | 94 |
| 104 | Location+ | 103 |
Yankees vs Red Sox MLB Betting Preview
New York Yankees
Over his last three starts, Fried has pitched to an ERA of 4.95 and allowed a strikeout-minus-walk ratio of just 8.9%. While this might feel like a decent time to fade the Yankees' ace, he has still allowed an xERA of 2.00 in that span and holds a Pitching+ rating of 111.
Given that Fried's stuff still seems the same as it typically is, and a larger sample of his work, his recent slump might not be anything worth reading into. He's pitched to an xERA of 2.27 this season and is still allowing very little hard contact, though his whiff and chase rates have been elevated this season.
The Yankees hold a wRC+ of 110 entering this matchup, and the lineup appears on track to live up to its lofty preseason expectations. They hold the third-highest expected slug rate in baseball and hold the fourth best BB/K ratio.
New York has been notably less dominant versus left-handed pitching thus far, but ranked first in wRC+ versus lefties in 2025, and likely will not hold such notable splits after a larger sample of play.
Boston Red Sox
We were high on the potential that Ranger Suarez could follow up on what was his best start with his new side on Friday versus the Tigers, but this matchup versus a Yankees side offering plenty of power could prove to be more difficult. Especially as the conditions are expected to be much more batter-friendly than they were in Friday's matchup.
Across his first four starts with the Red Sox, Suarez holds a 3.71 xFIP and a strikeout-minus-walk ratio of 10.5%. He's allowed a line-drive rate of 29.2%, and been hard-hit 38.5% of the time. He's never been a starter that relies on overwhelming stuff, but his Stuff+ of 94 is a concern, which correlates with his reduced whiff and K-rates.
Offensively, the Red Sox should prove to be a more formidable side than we have seen thus far, but nothing about their first 23 games has been overly convincing. They rank last in expected slug rate, 23rd in BB/K ratio, and 17th in hard-hit rate. They hold a wRC+ of 78 versus lefties and hold a hard-hit rate of just 29.1%.
Yankees vs Red Sox MLB Pick, Betting Analysis, Prop Bets
Though the Red Sox lineup should be able to find greater success moving forward, nothing about their current process has been encouraging, and the pressure from the team's passionate fanbase to figure it out continues to mount.
Fried has been quite average throughout his last three outings, but there are no massive red flags that suggest this downswing is anything meaningful, and the struggling Red Sox offer a strong spot for Fried to bounce back with a quality outing.
While Suarez enters off two excellent starts and will likely be an above-average starter this season, the Yankees' power-driven approach should be well-suited to expose Suarez's greatest issues.
At +145, there looks to be value in backing Fried to record a win. He should have a good chance of authoring a notably strong showing in this matchup, while he should have a good chance of receiving strong run support early on, as the Yankees' elite lineup should match up well with Suarez.
Pick: Max Fried to Record a Win +145 (Bet365, Play to +135)
