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Guardians vs White Sox Predictions, Odds, Start Time: MLB Picks for Wednesday

Guardians vs White Sox Predictions, Odds, Start Time: MLB Picks for Wednesday article feature image
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Jun 22, 2026; Chicago, Illinois, USA; Chicago White Sox center fielder Tristan Peters (29) runs into home plate to score the game winning run against Cleveland Guardians catcher Patrick Bailey (16) during the ninth inning at Rate Field. Mandatory Credit: Patrick Gorski-Imagn Images

The Chicago White Sox host the Cleveland Guardians on June 24, 2026. First pitch from Rate Field is scheduled for 2:10 p.m. ET. The game will be broadcast on CLEG.

The Guardians are favored by -118 on the moneyline and by -1.5 on the run line. The White Sox are +100 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.

Find my MLB picks and Guardians vs White Sox prediction below, as well as probable pitchers, weather report, and more.


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Guardians vs White Sox Prediction

  • Guardians vs White Sox Pick: Under 8.5

My Guardians vs White Sox best bet is on the under. Make sure to find the best odds by checking our live MLB odds page.


Guardians vs White Sox Odds, Run Line

Guardians Logo
Wednesday, Jun 24
2:10 p.m. ET
CLEG
White Sox Logo
Guardians Odds
SpreadTotalMoneyline
-1.5
+143
8.5
-103o / -117u
-114
White Sox Odds
SpreadTotalMoneyline
+1.5
-174
8.5
-103o / -117u
-105
Odds via DraftKings. Get up-to-the-minute MLB odds here.
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  • Guardians vs White Sox moneyline: Guardians -114, White Sox -105
  • Guardians vs White Sox over/under: 8.5 runs
  • Guardians vs White Sox spread: Guardians -1.5

Guardians vs White Sox Probable Pitchers

Tanner Bibee (RHP, CLE)StatErick Fedde (RHP, CWS)
2-8W-L2-6
0.6fWAR (FanGraphs)-0.3
4.03 / 4.57ERA / xERA4.46 / 4.49
4.66 / 4.10FIP / xFIP5.59 / 5.00
13.7%K-BB%6.8%
38.7%GB%38.2%
.253BABIP.264
106Stuff+90
100Location+107

Guardians vs White Sox MLB Betting Preview

This game triggered one of our Action PRO betting systems, powered by Evan Abrams:

In matchups between winning teams, sportsbooks often inflate totals based on perceived offensive strength, yet these teams also tend to have stronger pitching and tighter late-game execution, creating a profitable edge on the Under.


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Guardians vs White Sox Pick, Betting Analysis

I've been looking to bet Unders in this series, given that both teams are without their best hitters. Jose Ramirez is on the shelf for Cleveland, while Munetaka Murakami is on the IL for Chicago.

Both these lineups are super watered down without them. Sean Zerillo projects Cleveland's current lineup for a 93 wRC+ against right-handed pitching, and he projects the White Sox's current lineup with a 97 wRC+ against righties.

Opening Pitch: Zerillo's MLB Projections via BARTOLO Image

While I don't like either starting pitcher or the White Sox bullpen, the Guardians have a top-10 bullpen and defense, which compensates for that.

Pick: Under 8.5


Guardians vs White Sox Weather


Get the latest coverage on MLB Weather.
Author Profile
About the Author

Tanner McGrath covers college basketball, college football and Major League Baseball at Action Network. He is a contributor to Payoff Pitch, Action Network’s Major League Baseball betting podcast. He's been working in the space for more than five years with past journalism experience in Canadian collegiate sports, finance and economics. He has an obsession with America East basketball, betting the Miami Marlins and sweating out home underdogs.

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