White Sox vs. Red Sox Odds & Betting Predictions - April 21, 2025

White Sox at Red Sox

3:10 pm • NESN

Chicago White Sox

38-68

2 - 4

Boston Red Sox

57-50

pitcher		team	era	w-l
W.Buehler			5.72	6-6
J.Cannon			4.48	4-7

MatchupOpenSpreadTotalMoneyline
White Sox 38-68	+1.5	+1.5+124	o9-113	+240
Red Sox 57-50	u9	-1.5-148	u9-105	-298

Monday 3:10 p.m.

April 21, 2025

Fenway ParkBoston

CWS +2.5 (Live)-125

CWS +2.5-125

CWS o3.5 Team Total+105

0.5u

W.Buehler u1.5 BB+100

Under 9-105

0.95u

White Sox rank dead last in MLB in avg (.195), SLG (.306), OBP (.271). Just 2.89 runs/game on the road. Buehler induces weak contact (2.10 GB/FB), ideal at Fenway. White Sox 5th-worst in team wRC+ vs RHP. Boston’s bats cooled off – just .230 avg over last 10. Despite 6.2 runs/game at home, they’ve slowed vs weaker arms. Cannon flashed upside (4 K, 0 ER in 4 IP vs Athletics). Under has hit in 9 of last 12 matchups at Fenway between these teams. Pace, form, and splits all favor a lower score. Sox lack power, Buehler keeps ball down, Cannon’s better than full line shows. Wind light, no weather edge. Expect a grind.

Under 9-110

J.Cannon o4.5 Ks+106

BOS u5.5 Team Total-122

Under 0.5 (1st Inn)-110

1.1u

BOS -1.5-130

CWS +1.5+116

BOS -1.5-134

0.75u

Sticky sock

R.Devers o2.5 Hits + Runs + RBIs+110

Under 9-110

0.91u

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White Sox vs. Red Sox: Back Bregman on Patriots' Day
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Apr 21, 2025 UTC

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No props found

MLB Public Betting

Red Sox are 3-2 in their last 5 games.
Red Sox are 3-2 in their last 5 games against the spread
Red Sox are 28-24 in their road games against the spread
The totals have gone OVER in 1 of Red Sox' last 5 games
The totals have gone OVER in 22 of Red Sox' 55 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Red Sox	58-49	30-25	28-24	36-31	22-16
White Sox	61-45	30-23	31-22	0-2	61-43

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Red Sox	49-56-2	22-31-2	27-25	31-34-2	18-20
White Sox	47-55-4	28-22-3	19-33-1	0-2	47-53-4

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Red Sox	57-50	34-21	23-29	40-27	17-21
White Sox	38-68	22-31	16-37	1-1	37-67

date	opponent	score	spread	over/under	moneyline
Apr 20th	CWS	L 4-8	-1.5 L	O 9.5	CWS -290
Apr 19th	CWS	W 4-3	-1.5 L	U 9	BOS -367
Apr 18th	CWS	W 10-3	-1.5 W	O 9.5	BOS -238
Apr 16th	@TB	W 1-0	+1.5 W	U 9	BOS +114
Apr 15th	@TB	W 7-4	+1.5 W	O 9	BOS +110

Tanner Houck
SP
Houck is out with arm
Out
Patrick Sandoval
SP
Sandoval is out with elbow
Out
Kutter Crawford
SP
Crawford is out with knee
Out

Ryan Noda
1B
Noda is out with quad
Out
Ky Bush
SP
Bush is out with elbow
Out
Drew Thorpe
SP
Thorpe is out with elbow
Out
Shane Smith
SP
Smith is out with ankle
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RJ.Cannon, P	90	6	4	4
LT.Gilbert, P	23	1	3	0
RP.Murfee, P	17	1	1	0

HITTERS	H-AB	R	HR	RBI
1N.Maton, 1B	1-1	1	0	0
1B.Dalbec, PH	0-1	0	0	0
1B.Dalbec, 1B	0-1	0	0	0
2A.Benintendi, DH	2-3	1	1	1
3L.Robert, CF	0-4	0	0	0
4E.Quero, C	0-4	0	0	1
5L.Sosa, 2B	1-4	0	0	0
6M.Vargas, 3B	0-4	0	0	0
7B.Baldwin, LF	1-4	0	0	0
7B.Baldwin, SS	1-4	0	0	0
8M.Taylor, RF	0-3	0	0	0
8M.Thaiss, PH	0-1	0	0	0
9J.Amaya, SS	0-2	0	0	0
9J.Palacios, PH	0-1	0	0	0
9J.Palacios, LF	0-1	0	0	0

PITCHER	PC	IP	K	ER
RW.Buehler, P	100	7	9	1
LA.Chapman, P	16	1	1	1
RJ.Slaten, P	12	1	1	0

HITTERS	H-AB	R	HR	RBI
1J.Duran, CF	1-4	1	0	0
1J.Duran, LF	1-4	1	0	0
2R.Devers, DH	0-3	0	0	0
3A.Bregman, 3B	1-2	1	0	0
4T.Story, SS	3-4	1	0	1
5W.Abreu, RF	0-3	0	0	0
6K.Campbell, 2B	2-3	0	0	2
7T.Casas, 1B	0-4	0	0	0
8R.Refsnyder, LF	1-4	1	1	1
8C.Rafaela, CF	0-0	0	0	0
9C.Narvaez, C	0-4	0	0	0