Roma vs. Lazio Odds & Betting Predictions - September 21, 2025

Roma at Lazio

10:30 am

Roma

12-7

1

1 - 0

Lazio

6-6-7

0

MatchupOpenSpreadTotalMoneyline
Roma 12-7	-1	-0.5+160	o2.5+125	N/A
Lazio 6-6-7	u2.5	+0.5-235	u2.5-164	N/A

location pin

Sunday 10:30 a.m.

September 21, 2025

Stadio OlimpicoRome

Serie A Public Betting

Lazio are 2-1 in their last 5 games.
Lazio are 2-3 in their last 5 games against the spread
Lazio are 3-6 in their road games against the spread
The totals have gone OVER in 4 of Lazio' last 5 games
The totals have gone OVER in 4 of Lazio' 10 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Lazio	7-12	4-6	3-6	5-6	2-6
Roma	3-2-1	0-2-1	3-0	3-2-1	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Lazio	6-13	4-6	2-7	6-5	0-8
Roma	4-2	2-1	2-1	4-2	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Lazio	6-6	4-2-4	2-4-3	5-1-5	1-5-2
Roma	4-2	1-2	3-0	4-2	N/A

date	opponent	score	spread	over/under	moneyline
Sep 14th	@SAS	L 0-1	-0.5 L	U 2.5	SAS -112
Aug 31st	VER	W 4-0	-1 W	O 2.5	-
Aug 24th	@COM	L 0-2	+0.5 L	U 2.5	COM +210
May 25th	LEC	L 0-1	-1.5 L	U 2.5	LEC -227
May 18th	@INT	L 2-2	+1 W	O 2.5	INT +392

Pedro
F
Shoulder Injury
Out Indefinitely
Patric
DEF
Patric is out with muscle
Out
Samuel Gigot
DEF
Ankle/Foot Injury
Out
Toma Basic
MID
Thigh Muscle Strain
Out

Mattia Zaccagni
MID
Zaccagni is suspended with yellow cards

See more SERIEA Injuries

Roma

Lazio

22

Fouls

14

11

Shots

11

6

Corners

3

4

Offsides

0

0

Red Cards

2

1

Yellow Cards

1

6

Shots On Goal

3

51%

Possession Time

49%

Roma

Goalkeeping

Lazio

Could not load odds

See more Serie A Odds

MatchupOverUnder
Roma 12-7	o1.5+175	u1.5-250
Lazio 6-6-7	o1.5+175	u1.5-250