Roma vs. Lazio Odds & Betting Predictions - September 21, 2025
Roma at Lazio
10:30 am
Roma
6-21
1 - 0

Lazio
3-3-20
Roma at Lazio Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Roma 6-2 | -1 | -0.5+160 | o2.5+125 | N/A |
Lazio 3-3-2 | u2.5 | +0.5-235 | u2.5-164 | N/A |

Stadio OlimpicoRoma
Line Movement Tracker
Roma vs. Lazio Public Betting Percentages
Roma
Public
Lazio
50%
Bets%
50%Money%
Betting Trends
- Lazio are 2-2 in their last 5 games.
- Lazio are 3-2 in their last 5 games against the spread
- Lazio are 2-2 in their road games against the spread
- The totals have gone OVER in 2 of Lazio' last 5 games
- The totals have gone OVER in 2 of Lazio' 4 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 4-4 | 2-2 | 2-2 | 2-2 | 2-2 | |
| 1-2 | 0-2 | 1-0 | 1-2 | N/A |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 3-5 | 2-2 | 1-3 | 3-1 | 0-4 | |
| 2-1 | 1-1 | 1-0 | 2-1 | N/A |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 2-3 | 2-1-1 | 1-2-1 | 2-1-1 | 1-2-1 | |
| 1-2 | 0-2 | 1-0 | 1-2 | N/A |
Last 5 Matchups
Lazio vs. Roma Injury Updates

Lazio Injuries
- PedroF
Shoulder Injury
Out Indefinitely
- Matteo GuendouziMID
Ankle/Foot Injury
Out Indefinitely
- Samuel GigotDEF
Ankle/Foot Injury
Out
- Toma BasicMID
Thigh Muscle Strain
Out
- Taty CastellanosF
Suspended
Out
- Matteo CancellieriF
Cancellieri is out with muscle
Out
- Nicolo RovellaMID
Rovella is out with groin
Out
- Nuno TavaresDEF
Tavares is out with muscle
Out
- Fisayo Dele-BashiruMID
Dele-Bashiru is out with thigh
Out

Roma Injuries
Team Stats

Roma
Lazio

22
Fouls
14
11
Shots
11
6
Corners
3
4
Offsides
0
0
Red Cards
2
1
Yellow Cards
1
6
Shots On Goal
3
51%
Possession Time
49%

Roma
Goalkeeping
Lazio

Roma vs. Lazio Odds Comparison
Could not load odds
Roma at Lazio Team Totals
MatchupOverUnder | ||
|---|---|---|
Roma 6-2 | o1.5+175 | u1.5-250 |
Lazio 3-3-2 | o1.5+175 | u1.5-250 |
