| Ruben Loftus-Cheek | MID | Out | Heel Injury | Heel Injury | Jan 5 |
| Christian Pulisic | F | Out | Knock | Knock | Mar 4 |
| Mike Maignan | GK | Out | Suspended | Suspended | Aug 20 |
| Luka Modric | MID | Doubtful | None | Modric is doubtful | Dec 1 |
| Fikayo Tomori | DEF | Out | Knock | Knock | Jul 11 |
| Pervis Estupinan | DEF | Out | Hamstring | Hamstring | Apr 21 |
| Rafael Leao | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 4 |
| Strahinja Pavlovic | DEF | Out indefinitely | Knock | Knock | Sep 20 |
| Ademola Lookman | F | Out indefinitely | Illness | Illness | Dec 27 |
| Sead Kolasinac | DEF | Out | Groin Strain | Groin Strain | Mar 31 |
| Raoul Bellanova | DEF | Out | Raoul Bellanova is expected to return Late December 2025 from Hamstring Injury. | Bellanova is out with hamstring | Dec 12 |
| Lazar Samardzic | MID | Out indefinitely | Knee Injury | Knee Injury | Feb 21 |
| Kamaldeen Sulemana | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | Nov 14 |
| Charles De Ketelaere | F | Out | Charles De Ketelaere is expected to return Late October 2025 from Thigh injury. | De Ketelaere is out with thigh | Oct 9 |
| Odilon Kossounou | DEF | Out indefinitely | None | Kossounou is injured | Feb 13 |
| Bacary Sagna | DEF | Out indefinitely | Groin Strain | Groin Strain | May 1 |
| Cheick Tidiane Diabaté | A | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Jun 17 |
| V. Behrami | MID | Out indefinitely | Hamstring | Hamstring | Apr 17 |
| M. Balotelli | A | Out indefinitely | Knock | Knock | May 27 |
| Andrea Belotti | F | Out | Andrea Belotti is expected to return Early April 2026 from Cruciate ligament injury. | Belotti is out with knee | Dec 5 |
| Yerry Mina | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 14 |
| Alberto Moreno | DEF | Out | Suspended | Suspended | Feb 18 |
| Diego Carlos | DEF | Out indefinitely | None | Carlos is injured | Jan 23 |
| Alvaro Morata | F | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| Alberto Cerri | F | Out indefinitely | None | Cerri is injured | May 22 |
| Edoardo Goldaniga | DEF | Out | Edoardo Goldaniga is expected to return Late December 2025 from Heel injury. | Goldaniga is out with heel | Dec 9 |
| Antonio Sanabria | F | Out | Suspended | Suspended | Feb 4 |
| Jeremy Sarmiento | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Michele Collocolo | MID | Doubtful | Michele Collocolo is Doubtful with Muscle injury. | Collocolo is doubtful with muscle | Dec 5 |
| Martin Payero | MID | Suspended | Martín Payero is serving a suspension for Yellow cards. | Payero is suspended with yellow cards | Dec 13 |
| B. Adekanye | A | Out indefinitely | Hamstring | Hamstring | Dec 30 |
| David De Gea | GK | Out indefinitely | Knock | Knock | Apr 5 |
| Moise Kean | F | Out | Suspended | Suspended | Sep 18 |
| Pablo Mari | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | May 13 |
| Robin Gosens | DEF | Doubtful | Robin Gosens is Doubtful with Thigh injury. | Gosens is doubtful with thigh | Dec 5 |
| Marin Pongracic | DEF | Out | Suspended | Suspended | Mar 6 |
| Abdelhamid Sabiri | MID | Out | Suspended | Suspended | Jun 16 |
| Tariq Lamptey | DEF | Out indefinitely | Tariq Lamptey is Unknown with Knee injury. | Lamptey is injured with knee | Aug 26 |
| Mattia Viti | DEF | Out indefinitely | None | Viti is injured | Feb 13 |
| Jacopo Fazzini | MID | Doubtful | Jacopo Fazzini is Doubtful with Physical discomfort. | Fazzini is doubtful with soreness | Dec 9 |
| Maxwel Cornet | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 9 |
| Aaron Martin | DEF | Out indefinitely | Groin Strain | Groin Strain | Sep 19 |
| Junior Messias | F | Out | Junior Messias is expected to return Late December 2025 from Muscle injury. | Messias is out with muscle | Dec 13 |
| Leo Ostigard | DEF | Out | Leo Østigard is expected to return Late December 2025 from Muscle injury. | Ostigard is out with muscle | Dec 13 |
| Benjamin Siegrist | GK | Out | Benjamin Siegrist is expected to return Late December 2025 from Broken finger. | Siegrist is out with finger | Dec 9 |
| Jean Akpa | MID | Out indefinitely | None | Akpa is injured | Feb 13 |
| Domagoj Bradaric | DEF | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Feb 5 |
| Enzo Ebosse | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 9 |
| Amin Sarr | F | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 11 |
| Armel Bella-Kotchap | DEF | Out | Shoulder Injury | Shoulder Injury | Apr 10 |
| Tomas Suslov | MID | Out | Tomas Suslov is expected to return Late February 2026 from Cruciate ligament injury. | Suslov is out with knee | Dec 5 |
| Moatasem Al-Musrati | MID | Out indefinitely | None | Al-Musrati is injured | May 9 |
| Henrikh Mkhitaryan | MID | Out indefinitely | Back Injury | Back Injury | Mar 31 |
| Yann Sommer | GK | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Dec 6 |
| Francesco Acerbi | DEF | Out | Francesco Acerbi is expected to return Early January 2026 from Muscle injury. | Acerbi is out with muscle | Dec 11 |
| Raffaele Di Gennaro | GK | Doubtful | Raffaele Di Gennaro is Doubtful with Broken hand. | Di Gennaro is doubtful with hand | Dec 5 |
| Tomas Palacios | DEF | Out | Tomás Palacios is expected to return Late December 2025 from Muscle injury. | Palacios is out with muscle | Dec 9 |
| Filip Kostic | F | Out indefinitely | Virus | Virus | Jan 24 |
| Arkadiusz Milik | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Apr 22 |
| Federico Gatti | DEF | Out | Federico Gatti is expected to return Mid January 2026 from Meniscus injury. | Gatti is out with knee | Dec 5 |
| Teun Koopmeiners | MID | Out indefinitely | None | Koopmeiners is injured | Nov 2 |
| Carlo Pinsoglio | GK | Out | Carlo Pinsoglio is expected to return Late December 2025 from Leg injury. | Pinsoglio is out with leg | Dec 9 |
| Pedro | F | Out indefinitely | Shoulder Injury | Shoulder Injury | Sep 28 |
| Matteo Guendouzi | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 2 |
| Samuel Gigot | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | Mar 13 |
| Toma Basic | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 14 |
| Taty Castellanos | F | Out | Suspended | Suspended | Jan 14 |
| Nicolo Rovella | MID | Doubtful | Nicolò Rovella is Doubtful with Groin injury. | Rovella is doubtful with groin | Dec 5 |
| Mario Gila | DEF | Suspended | Mario Gila is serving a suspension for Yellow/red card. | Gila is suspended with yellow/red card | Dec 7 |
| Gustav Isaksen | F | Out | Gustav Isaksen is expected to return Late December 2025 from Muscle injury. | Isaksen is out with muscle | Dec 9 |
| Lassana Coulibaly | MID | Out | Suspended | Suspended | May 24 |
| Frederic Guilbert | DEF | Out | Chest Injury | Chest Injury | Dec 12 |
| Tete Morente | F | Out indefinitely | Toe Injury | Toe Injury | Feb 16 |
| Medon Berisha | F | Out | Medon Berisha is expected to return Early January 2026 from Knee injury. | Berisha is out with knee | Dec 13 |
| Christian Fruchtl | GK | Doubtful | Christian Früchtl is Doubtful with Physical discomfort. | Fruchtl is doubtful with soreness | Dec 11 |
| Gaby Jean | DEF | Out indefinitely | Jean, Gaby: missing - injured | Jean is injured | Aug 22 |
| Alessandro Circati | DEF | Doubtful | Alessandro Circati is Doubtful with Sprained ankle. | Circati is doubtful with ankle | Dec 5 |
| Zion Suzuki | GK | Out | Zion Suzuki is expected to return Mid February 2026 from Broken hand. | Suzuki is out with hand | Dec 5 |
| Matija Frigan | F | Out | Matija Frigan is expected to return Early March 2026 from Cruciate ligament injury. | Frigan is out with knee | Dec 5 |
| Juan Cuadrado | DEF | Doubtful | Juan Cuadrado is Doubtful with Muscle injury. | Cuadrado is doubtful with muscle | Dec 5 |
| A. Tripaldelli | DEF | Out indefinitely | Knock | Knock | Nov 25 |
| Romelu Lukaku | F | Out | Romelu Lukaku is expected to return Early November 2025 from Thigh injury. | Lukaku is out with thigh | Oct 20 |
| Frank Anguissa | MID | Out | Suspended | Suspended | Feb 8 |
| Juan Jesus | DEF | Doubtful | Juan Jesus is Doubtful with Calf injury. | Jesus is doubtful with calf | Dec 13 |
| Alex Meret | GK | Out | Alex Meret is expected to return Mid January 2026 from Broken foot. | Meret is out with foot | Dec 5 |
| Stanislav Lobotka | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Dec 12 |
| Mathias Olivera | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 4 |
| Eljif Elmas | MID | Out indefinitely | None | Elmas is injured | Jan 1 |
| Nemanja Matic | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Feb 21 |
| Domenico Berardi | F | Out | Domenico Berardi is expected to return Early January 2026 from Thigh injury. | Berardi is out with thigh | Dec 5 |
| Filippo Romagna | DEF | Doubtful | Filippo Romagna is Doubtful with Calf injury. | Romagna is doubtful with calf | Dec 5 |
| Armand Lauriente | F | Out | Back Injury | Back Injury | Nov 14 |
| Edoardo Pieragnolo | DEF | Doubtful | Edoardo Pieragnolo is Doubtful with Muscle injury. | Pieragnolo is doubtful with muscle | Dec 5 |
| Yeferson Paz Blandon | DEF | Doubtful | Yeferson Paz is Doubtful with Physical discomfort. | Paz Blandon is doubtful with soreness | Dec 5 |
| Stefano Turati | GK | Doubtful | Stefano Turati is Doubtful with Physical discomfort. | Turati is doubtful with soreness | Dec 5 |
| Daniel Boloca | MID | Doubtful | Daniel Boloca is Doubtful with Physical discomfort. | Boloca is doubtful with soreness | Dec 5 |
| Laurs Skjellerup | F | Doubtful | Laurs Skjellerup is Doubtful with Muscle injury. | Skjellerup is doubtful with muscle | Dec 5 |
| Jeroen Zoet | GK | Out indefinitely | Knock | Knock | Oct 20 |
| Daniele Verde | MID | Out indefinitely | Hamstring | Hamstring | May 5 |
| Adam Masina | DEF | Out indefinitely | Knee Injury | Knee Injury | Dec 29 |
| Adrien Tameze | MID | Out | Back Injury | Back Injury | Oct 6 |
| Guillermo Maripan | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 13 |
| Perr Schuurs | DEF | Out indefinitely | Knee Injury | Knee Injury | Jul 19 |
| Zannetos Savva | MID | Doubtful | Savva, Zannetos: doubtful - injured | Savva is doubtful | Aug 22 |
| Kingsley Ehizibue | DEF | Out indefinitely | Concussion | Concussion | Apr 17 |
| Adam Buksa | F | Out | Ankle Ligaments | Ankle Ligaments | Apr 11 |
| Hassane Kamara | DEF | Doubtful | Hassane Kamara is Doubtful with Foot injury. | Kamara is doubtful with foot | Dec 5 |
Benevento Calcio
Brescia Calcio
FC Crotone
S.P.A.L. 2013
