| Ruben Loftus-Cheek | MID | Out | Heel Injury | Heel Injury | Jan 5 |
| Fikayo Tomori | DEF | Out | Knock | Knock | Jul 11 |
| Strahinja Pavlovic | DEF | Out indefinitely | Knock | Knock | Sep 20 |
| Lazar Samardzic | MID | Out indefinitely | Knee Injury | Knee Injury | Feb 21 |
| Giorgio Scalvini | DEF | Doubtful | Giorgio Scalvini is Doubtful with Thigh injury. | Scalvini is doubtful with thigh | May 13 |
| Bacary Sagna | DEF | Out indefinitely | Groin Strain | Groin Strain | May 1 |
| Cheick Tidiane Diabaté | A | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Jun 17 |
| V. Behrami | MID | Out indefinitely | Hamstring | Hamstring | Apr 17 |
| M. Balotelli | A | Out indefinitely | Knock | Knock | May 27 |
| Alberto Moreno | DEF | Out | Suspended | Suspended | Feb 18 |
| Diego Carlos | DEF | Out indefinitely | None | Carlos is injured | Jan 23 |
| Alvaro Morata | F | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| B. Adekanye | A | Out indefinitely | Hamstring | Hamstring | Dec 30 |
| David De Gea | GK | Out indefinitely | Knock | Knock | Apr 5 |
| Moise Kean | F | Out | Suspended | Suspended | Sep 18 |
| Abdelhamid Sabiri | MID | Out | Suspended | Suspended | Jun 16 |
| Manor Solomon | MID | Out | Knee Injury | Knee Injury | Jan 5 |
| Oliver Christensen | GK | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Mar 6 |
| Maxwel Cornet | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 9 |
| Aaron Martin | DEF | Out indefinitely | Groin Strain | Groin Strain | Sep 19 |
| Jean Akpa | MID | Out indefinitely | None | Akpa is injured | Feb 13 |
| Domagoj Bradaric | DEF | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Feb 5 |
| Amin Sarr | F | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 11 |
| Armel Bella-Kotchap | DEF | Out | Shoulder Injury | Shoulder Injury | Apr 10 |
| Moatasem Al-Musrati | MID | Out indefinitely | None | Al-Musrati is injured | May 9 |
| Henrikh Mkhitaryan | MID | Out indefinitely | Back Injury | Back Injury | Mar 31 |
| Yann Sommer | GK | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Dec 6 |
| Filip Kostic | F | Out indefinitely | Virus | Virus | Jan 24 |
| Arkadiusz Milik | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Apr 22 |
| Pedro | F | Out indefinitely | Shoulder Injury | Shoulder Injury | Sep 28 |
| Patric | DEF | Out | Patric is expected to return Late May 2026 from Muscle injury. | Patric is out with muscle | May 16 |
| Samuel Gigot | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | Mar 13 |
| Toma Basic | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 14 |
| Mattia Zaccagni | F | Out | Mattia Zaccagni is expected to return Late May 2026 from Muscle injury. | Zaccagni is out with muscle | May 16 |
| Edoardo Motta | GK | Out | Edoardo Motta is expected to return Late May 2026 from Muscle injury. | Motta is out with muscle | May 16 |
| Lassana Coulibaly | MID | Out | Suspended | Suspended | May 24 |
| Jacob Ondrejka | MID | Doubtful | Jacob Ondrejka is Doubtful with Physical discomfort. | Ondrejka is doubtful with soreness | May 13 |
| Filippo Rinaldi | GK | Doubtful | Filippo Rinaldi is Doubtful with Physical discomfort. | Rinaldi is doubtful with soreness | May 16 |
| Francesco Coppola | DEF | Doubtful | Francesco Coppola is Doubtful with Physical discomfort. | Coppola is doubtful with soreness | May 15 |
| A. Tripaldelli | DEF | Out indefinitely | Knock | Knock | Nov 25 |
| Frank Anguissa | MID | Out | Suspended | Suspended | Feb 8 |
| Matteo Politano | F | Suspended | Matteo Politano is serving a suspension for Yellow cards. | Politano is suspended with yellow cards | May 13 |
| Stanislav Lobotka | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Dec 12 |
| Eljif Elmas | MID | Out indefinitely | None | Elmas is injured | Jan 1 |
| Nemanja Matic | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Feb 21 |
| Armand Lauriente | F | Out | Back Injury | Back Injury | Nov 14 |
| Sebastian Walukiewicz | DEF | Out | Sebastian Walukiewicz is expected to return Late May 2026 from Leg injury. | Walukiewicz is out with leg | May 15 |
| Jeroen Zoet | GK | Out indefinitely | Knock | Knock | Oct 20 |
| Daniele Verde | MID | Out indefinitely | Hamstring | Hamstring | May 5 |
| Adam Masina | DEF | Out indefinitely | Knee Injury | Knee Injury | Dec 29 |
| Adrien Tameze | MID | Out | Back Injury | Back Injury | Oct 6 |
| Guillermo Maripan | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 13 |
| Enzo Ebosse | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 9 |
| Sandro Kulenovic | F | Suspended | Sandro Kulenovic is serving a suspension for Yellow cards. | Kulenovic is suspended with yellow cards | Dec 21 |
| Nicolo Zaniolo | MID | Out for season | Nicolò Zaniolo is Out for season with Back injury. | Zaniolo is out for season with back | May 16 |
| Kingsley Ehizibue | DEF | Out indefinitely | Concussion | Concussion | Apr 17 |
| Adam Buksa | F | Out | Ankle Ligaments | Ankle Ligaments | Apr 11 |
Benevento Calcio
Brescia Calcio
FC Crotone
S.P.A.L. 2013
