| Lazar Samardzic | MID | Out indefinitely | Knee Injury | Knee Injury | Feb 21 |
| Bacary Sagna | DEF | Out indefinitely | Groin Strain | Groin Strain | May 1 |
| Cheick Tidiane Diabaté | A | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Jun 17 |
| V. Behrami | MID | Out indefinitely | Hamstring | Hamstring | Apr 17 |
| M. Balotelli | A | Out indefinitely | Knock | Knock | May 27 |
| Kingstone Mutandwa | F | Doubtful | Kingstone Mutandwa is Doubtful with Knock injury. | Mutandwa is doubtful with knock injury | Dec 6 |
| Marlon Mustapha | F | Out indefinitely | Illness | Illness | Apr 10 |
| Alberto Grassi | MID | Suspended | Alberto Grassi is serving a suspension for Red card. | Grassi is suspended with red card | May 25 |
| Milan Djuric | F | Suspended | Milan Djuric is serving a suspension for Red card. | Djuric is suspended with red card | May 25 |
| B. Adekanye | A | Out indefinitely | Hamstring | Hamstring | Dec 30 |
| David De Gea | GK | Out indefinitely | Knock | Knock | Apr 5 |
| Moise Kean | F | Out | Suspended | Suspended | Sep 18 |
| Oliver Christensen | GK | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Mar 6 |
| Fabiano Parisi | DEF | Out | Fabiano Parisi is expected to return Early December 2026 from Cruciate ligament injury. | Parisi is out with knee | Jun 1 |
| Nicolas Valentini | DEF | Suspended | Nicolás Valentini is serving a suspension for Yellow/red card. | Valentini is suspended with yellow/red card | May 25 |
| Aaron Martin | DEF | Out indefinitely | Groin Strain | Groin Strain | Sep 19 |
| Jean Akpa | MID | Out indefinitely | None | Akpa is injured | Feb 13 |
| Domagoj Bradaric | DEF | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Feb 5 |
| Amin Sarr | F | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 11 |
| Armel Bella-Kotchap | DEF | Out | Shoulder Injury | Shoulder Injury | Apr 10 |
| Henrikh Mkhitaryan | MID | Out indefinitely | Back Injury | Back Injury | Mar 31 |
| Samuel Gigot | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | Mar 13 |
| Gustav Isaksen | F | Out indefinitely | Gustav Isaksen is Unknown with Groin injury. | Isaksen is injured with groin | Jun 3 |
| Lassana Coulibaly | MID | Out | Suspended | Suspended | May 24 |
| Ylber Ramadani | MID | Suspended | Ylber Ramadani is serving a suspension for Yellow cards. | Ramadani is suspended with yellow cards | May 25 |
| Rares Burnete | F | Out | Rares Burnete is expected to return Mid December 2025 from Unknown. | Burnete is out with unknown | Dec 4 |
| Rachid Kouda | MID | Suspended | Rachid Kouda is serving a suspension for Red card. | Kouda is suspended with red card | Nov 10 |
| Anthony Partipilo | F | Doubtful | Anthony Partipilo is Doubtful with Unknown. | Partipilo is doubtful with unknown | Jan 21 |
| A. Tripaldelli | DEF | Out indefinitely | Knock | Knock | Nov 25 |
| Frank Anguissa | MID | Out | Suspended | Suspended | Feb 8 |
| Stanislav Lobotka | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Dec 12 |
| Nemanja Matic | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Feb 21 |
| Armand Lauriente | F | Out | Back Injury | Back Injury | Nov 14 |
| Daniele Verde | MID | Out indefinitely | Hamstring | Hamstring | May 5 |
| Adam Masina | DEF | Out indefinitely | Knee Injury | Knee Injury | Dec 29 |
| Pietro Pellegri | F | Out | Back Injury | Back Injury | May 19 |
| Aaron Ciammaglichella | MID | Doubtful | Aaron Ciammaglichella is Doubtful with Overload. | Ciammaglichella is doubtful with rest | Sep 26 |
| Jonathan Silva | MID | Doubtful | Jonathan Silva is Doubtful with Unknown. | Silva is doubtful with unknown | Nov 1 |
| Adam Buksa | F | Out | Ankle Ligaments | Ankle Ligaments | Apr 11 |
| Enzo Ebosse | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 9 |
| Christian Kabasele | DEF | Suspended | Christian Kabasele is serving a suspension for Red card. | Kabasele is suspended with red card | May 25 |
Benevento Calcio
Brescia Calcio
FC Crotone
S.P.A.L. 2013
