| Ruben Loftus-Cheek | MID | Out | Heel Injury | Heel Injury | Jan 5 |
| Christian Pulisic | F | Out | Knock | Knock | Mar 4 |
| Mike Maignan | GK | Out | Suspended | Suspended | Aug 20 |
| Luka Modric | MID | Doubtful | None | Modric is doubtful | Dec 1 |
| Fikayo Tomori | DEF | Out | Knock | Knock | Jul 11 |
| Pervis Estupinan | DEF | Out | Hamstring | Hamstring | Apr 21 |
| Rafael Leao | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Oct 4 |
| Strahinja Pavlovic | DEF | Out indefinitely | Knock | Knock | Sep 20 |
| Ademola Lookman | F | Out indefinitely | Illness | Illness | Dec 27 |
| Sead Kolasinac | DEF | Out | Groin Strain | Groin Strain | Mar 31 |
| Gianluca Scamacca | F | Out | Gianluca Scamacca is expected to return Late January 2026 from Thigh injury. | Scamacca is out with thigh | Jan 7 |
| Raoul Bellanova | DEF | Out | Raoul Bellanova is expected to return Mid January 2026 from Hamstring Injury. | Bellanova is out with hamstring | Dec 28 |
| Lazar Samardzic | MID | Out indefinitely | Knee Injury | Knee Injury | Feb 21 |
| Kamaldeen Sulemana | F | Out | Ankle/Foot Injury | Ankle/Foot Injury | Nov 14 |
| Charles De Ketelaere | F | Out | Charles De Ketelaere is expected to return Late October 2025 from Thigh injury. | De Ketelaere is out with thigh | Oct 9 |
| Odilon Kossounou | DEF | Out indefinitely | None | Kossounou is injured | Feb 13 |
| Bacary Sagna | DEF | Out indefinitely | Groin Strain | Groin Strain | May 1 |
| Cheick Tidiane Diabaté | A | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Jun 17 |
| V. Behrami | MID | Out indefinitely | Hamstring | Hamstring | Apr 17 |
| M. Balotelli | A | Out indefinitely | Knock | Knock | May 27 |
| Andrea Belotti | F | Out | Andrea Belotti is expected to return Early April 2026 from Cruciate ligament injury. | Belotti is out with knee | Dec 5 |
| Yerry Mina | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 14 |
| Sebastiano Esposito | F | Out indefinitely | Sebastiano Esposito is Unknown with Muscle injury. | Esposito is injured with muscle | Jan 2 |
| Michael Folorunsho | MID | Out | Michael Folorunsho is expected to return Mid January 2026 from Leg injury. | Folorunsho is out with leg | Dec 28 |
| Alessandro Deiola | MID | Out | Alessandro Deiola is expected to return Late January 2026 from Thigh injury. | Deiola is out with thigh | Jan 6 |
| Alberto Moreno | DEF | Out | Suspended | Suspended | Feb 18 |
| Diego Carlos | DEF | Out indefinitely | None | Carlos is injured | Jan 23 |
| Alvaro Morata | F | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| Alberto Cerri | F | Out indefinitely | None | Cerri is injured | May 22 |
| Edoardo Goldaniga | DEF | Doubtful | Edoardo Goldaniga is Doubtful with Heel injury. | Goldaniga is doubtful with heel | Dec 28 |
| Antonio Sanabria | F | Out | Suspended | Suspended | Feb 4 |
| Jeremy Sarmiento | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 11 |
| Michele Collocolo | MID | Doubtful | Michele Collocolo is Doubtful with Muscle injury. | Collocolo is doubtful with muscle | Dec 28 |
| B. Adekanye | A | Out indefinitely | Hamstring | Hamstring | Dec 30 |
| David De Gea | GK | Out indefinitely | Knock | Knock | Apr 5 |
| Moise Kean | F | Out | Suspended | Suspended | Sep 18 |
| Pablo Mari | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | May 13 |
| Marin Pongracic | DEF | Out | Suspended | Suspended | Mar 6 |
| Abdelhamid Sabiri | MID | Out | Suspended | Suspended | Jun 16 |
| Manor Solomon | MID | Out | Knee Injury | Knee Injury | Jan 5 |
| Tariq Lamptey | DEF | Out indefinitely | Tariq Lamptey is Unknown with Knee injury. | Lamptey is injured with knee | Aug 26 |
| Oliver Christensen | GK | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Mar 6 |
| Mattia Viti | DEF | Out indefinitely | None | Viti is injured | Feb 13 |
| Maxwel Cornet | MID | Out | Calf/Shin Injury | Calf/Shin Injury | Mar 9 |
| Aaron Martin | DEF | Out indefinitely | Groin Strain | Groin Strain | Sep 19 |
| Junior Messias | F | Out | Junior Messias is expected to return Mid January 2026 from Muscle injury. | Messias is out with muscle | Dec 28 |
| Sebastian Otoa | DEF | Doubtful | Sebastian Otoa is Doubtful with Thigh injury. | Otoa is doubtful with thigh | Jan 6 |
| Benjamin Siegrist | GK | Out | Benjamin Siegrist is expected to return Mid January 2026 from Broken finger. | Siegrist is out with finger | Dec 28 |
| Jean Akpa | MID | Out indefinitely | None | Akpa is injured | Feb 13 |
| Domagoj Bradaric | DEF | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Feb 5 |
| Enzo Ebosse | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Sep 9 |
| Amin Sarr | F | Out | Thigh Muscle Strain | Thigh Muscle Strain | Apr 11 |
| Armel Bella-Kotchap | DEF | Out | Shoulder Injury | Shoulder Injury | Apr 10 |
| Tomas Suslov | MID | Out | Tomas Suslov is expected to return Late February 2026 from Cruciate ligament injury. | Suslov is out with knee | Dec 5 |
| Moatasem Al-Musrati | MID | Out indefinitely | None | Al-Musrati is injured | May 9 |
| Henrikh Mkhitaryan | MID | Out indefinitely | Back Injury | Back Injury | Mar 31 |
| Yann Sommer | GK | Out indefinitely | Ankle Ligaments | Ankle Ligaments | Dec 6 |
| Raffaele Di Gennaro | GK | Out | Raffaele Di Gennaro is expected to return Mid January 2026 from Broken hand. | Di Gennaro is out with hand | Dec 28 |
| Tomas Palacios | DEF | Doubtful | Tomás Palacios is Doubtful with Muscle injury. | Palacios is doubtful with muscle | Dec 28 |
| Filip Kostic | F | Out indefinitely | Virus | Virus | Jan 24 |
| Daniele Rugani | DEF | Out | Daniele Rugani is expected to return Early February 2026 from Calf injury. | Rugani is out with calf | Dec 21 |
| Arkadiusz Milik | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Apr 22 |
| Federico Gatti | DEF | Out | Federico Gatti is expected to return Mid January 2026 from Meniscus injury. | Gatti is out with knee | Jan 2 |
| Teun Koopmeiners | MID | Out indefinitely | None | Koopmeiners is injured | Nov 2 |
| Francisco Conceicao | F | Doubtful | Chico Conceição is Doubtful with Muscle injury. | Conceicao is doubtful with muscle | Jan 5 |
| Pedro | F | Out indefinitely | Shoulder Injury | Shoulder Injury | Sep 28 |
| Matteo Guendouzi | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 2 |
| Patric | DEF | Out | Patric is expected to return Mid January 2026 from Muscle injury. | Patric is out with muscle | Jan 5 |
| Adam Marusic | DEF | Suspended | Adam Marusic is serving a suspension for Red card. | Marusic is suspended with red card | Jan 4 |
| Samuel Gigot | DEF | Out | Ankle/Foot Injury | Ankle/Foot Injury | Mar 13 |
| Toma Basic | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 14 |
| Tijjani Noslin | F | Suspended | Tijjani Noslin is serving a suspension for Yellow/red card. | Noslin is suspended with yellow/red card | Jan 4 |
| Lassana Coulibaly | MID | Out | Suspended | Suspended | May 24 |
| Frederic Guilbert | DEF | Out | Chest Injury | Chest Injury | Dec 12 |
| Tete Morente | F | Out indefinitely | Toe Injury | Toe Injury | Feb 16 |
| Medon Berisha | F | Out | Medon Berisha is expected to return Mid January 2026 from Knee injury. | Berisha is out with knee | Dec 28 |
| Christian Fruchtl | GK | Doubtful | Christian Früchtl is Doubtful with Physical discomfort. | Fruchtl is doubtful with soreness | Dec 11 |
| Zion Suzuki | GK | Out | Zion Suzuki is expected to return Mid February 2026 from Broken hand. | Suzuki is out with hand | Dec 28 |
| Matija Frigan | F | Out | Matija Frigan is expected to return Early March 2026 from Cruciate ligament injury. | Frigan is out with knee | Dec 5 |
| Juan Cuadrado | DEF | Doubtful | Juan Cuadrado is Doubtful with Muscle injury. | Cuadrado is doubtful with muscle | Dec 28 |
| Mateus Lusuardi | DEF | Doubtful | Mateus Lusuardi is Doubtful with Physical discomfort. | Lusuardi is doubtful with soreness | Jan 2 |
| A. Tripaldelli | DEF | Out indefinitely | Knock | Knock | Nov 25 |
| Romelu Lukaku | F | Out | Romelu Lukaku is expected to return Early November 2025 from Thigh injury. | Lukaku is out with thigh | Oct 20 |
| Frank Anguissa | MID | Out | Suspended | Suspended | Feb 8 |
| Stanislav Lobotka | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Dec 12 |
| Mathias Olivera | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 4 |
| Eljif Elmas | MID | Out indefinitely | None | Elmas is injured | Jan 1 |
| Antonio Vergara | MID | Out | Antonio Vergara is expected to return Mid January 2026 from Muscle injury. | Vergara is out with muscle | Jan 5 |
| Sam Beukema | DEF | Doubtful | Sam Beukema is Doubtful with Physical discomfort. | Beukema is doubtful with soreness | Dec 28 |
| Nemanja Matic | MID | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Feb 21 |
| Domenico Berardi | F | Doubtful | Domenico Berardi is Doubtful with Thigh injury. | Berardi is doubtful with thigh | Dec 28 |
| Filippo Romagna | DEF | Doubtful | Filippo Romagna is Doubtful with Calf injury. | Romagna is doubtful with calf | Dec 28 |
| Armand Lauriente | F | Out | Back Injury | Back Injury | Nov 14 |
| Cristian Volpato | MID | Out | Cristian Volpato is expected to return Mid January 2026 from Muscle injury. | Volpato is out with muscle | Jan 5 |
| Edoardo Pieragnolo | DEF | Doubtful | Edoardo Pieragnolo is Doubtful with Muscle injury. | Pieragnolo is doubtful with muscle | Dec 28 |
| Daniel Boloca | MID | Doubtful | Daniel Boloca is Doubtful with Muscle injury. | Boloca is doubtful with muscle | Dec 19 |
| Jeroen Zoet | GK | Out indefinitely | Knock | Knock | Oct 20 |
| Daniele Verde | MID | Out indefinitely | Hamstring | Hamstring | May 5 |
| Adam Masina | DEF | Out indefinitely | Knee Injury | Knee Injury | Dec 29 |
| Adrien Tameze | MID | Out | Back Injury | Back Injury | Oct 6 |
| Guillermo Maripan | DEF | Out | Thigh Muscle Strain | Thigh Muscle Strain | Mar 13 |
| Perr Schuurs | DEF | Out indefinitely | Knee Injury | Knee Injury | Jul 19 |
| Zannetos Savva | MID | Doubtful | Savva, Zannetos: doubtful - injured | Savva is doubtful | Aug 22 |
| Kingsley Ehizibue | DEF | Out indefinitely | Concussion | Concussion | Apr 17 |
| Adam Buksa | F | Out | Ankle Ligaments | Ankle Ligaments | Apr 11 |
| Saba Goglichidze | DEF | Out | Saba Goglichidze is expected to return Mid January 2026 from Muscle injury. | Goglichidze is out with muscle | Dec 30 |
Benevento Calcio
Brescia Calcio
FC Crotone
S.P.A.L. 2013
