Owls vs. 49ers Odds & Betting Predictions - October 18, 2025
Owls at 49ers
7:30 pm • ESPN+Owls at 49ers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Owls 5-7 | -12.5 | -10-108 | o47.5-110 | -370 |
49ers 1-11 | u47.5 | +10-112 | u47.5-110 | +300 |

Jerry Richardson StadiumCharlotte
Owls vs. 49ers Expert Picks
Collin Wilson
Last 30d: 33-16-3 (+13.8u)
CHA +11.5-110
0.55u
Project Charlotte +6; Temple potentially missing multiple players on DL and LB w injury.
Owls vs. 49ers Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Owls vs. 49ers Public Betting Percentages
Betting Trends
- 49ers are 1-4 in their last 5 games.
- 49ers are 1-4 in their last 5 games against the spread
- 49ers are 4-1 in their road games against the spread
- The totals have gone OVER in 3 of 49ers' last 5 games
- The totals have gone OVER in 4 of 49ers' 6 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Team Stats
212
YDS
158
16/23
Comps/Atts
15/29
9.217391304347826
YPA
5.448275862068965
3/0
TDs/INTs
1/1
1/8
Sacks/Yards
2/7
Owls vs. 49ers Odds Comparison
Could not load odds
Owls at 49ers Team Totals
MatchupOverUnder | ||
|---|---|---|
Owls 5-7 | o28.5-114 | u28.5-116 |
49ers 1-11 | o17.5-111 | u17.5-116 |






