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Louisville vs. Clemson Odds & Betting Predictions - February 28, 2026

Louisville at Clemson

7:00 pm • ESPN2

Louisville Cardinals

20-8
75
75 - 80

Clemson Tigers

20-8
80

Louisville at Clemson Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Louisville
20-8
-1.5
-2-112
o147-112
-138
Clemson
20-8
u145.5
+2-107
u147-110
+115
location pinSaturday 7:00 p.m.
February 28, 2026
Littlejohn ColiseumClemson
Louisville vs. Clemson Expert Picks
CTO
CTO
Last 30d: 24-19-0 (+25.1u)
CLEM +105
2.1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 90-80-6 (+2.2u)
CLEM +1.5-110
1u
John Feltman
John Feltman
Last 30d: 84-68-4 (+3.2u)
CLEM +1.5-110
0.5u
Stuck 🚨
Stuck 🚨
Last 30d: 61-58-2 (+1.1u)
CLEM +2-110
0.36u
Mike McNamara
Mike McNamara
Last 30d: 86-89-0 (+3.3u)
CLEM +2-110
0.3u
JMann
JMann
Last 30d: 40-30-0 (+7.7u)
CLEM +105
1.05u
Sean Paul
Sean Paul
Last 30d: 38-50-0 (-15.0u)
LOU -1.5-103
1u
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Louisville vs. Clemson Previews & Analysis

  • Louisville vs Clemson: This Side is Mediocre article feature image

    Louisville vs Clemson: This Side is Mediocre

    Sean Paul•
    Feb 28, 2026 UTC
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Prop Odds Comparison

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No props found

Line Movement Tracker

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Louisville vs. Clemson Public Betting Percentages

Away Logo

Louisville

Public

Home Logo

Clemson

66%

Bets%

34%

Money%

NCAAB Public Betting Right Arrow

Betting Trends

  • Clemson are 1-4 in their last 5 games.
  • Clemson are 2-3 in their last 5 games against the spread
  • Clemson are 9-3 in their road games against the spread
  • The totals have gone OVER in 2 of Clemson' last 5 games
  • The totals have gone OVER in 5 of Clemson' 16 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Clemson		16-127-99-313-123-0
Louisville		13-158-85-710-100-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Clemson		11-175-116-610-151-2
Louisville		10-185-115-78-120-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Clemson		20-8N/AN/A20-50-3
Louisville		20-8N/AN/A15-50-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Feb 21stFSUL 65-70-8.5 LU 145.5FSU -440
Feb 19th@WAKEL 77-85-3.5 LO 140WAKE -190
Feb 14th@DUKEL 54-67+13.5 WU 134DUKE +720
Feb 12thVTL 66-76-8.5 LO 138.5VT -400
Feb 8th@CALW 77-55-4.5 WU 139.5CLEM -198

Louisville vs. Clemson Injury Updates

Louisville Injuries

    Clemson Injuries

    • Zac Foster
      G

      Foster is out for season with knee

      Out for Season

    • Trent Steinour
      F/C

      Steinour is questionable with undisclosed

      Questionable

    See more NCAAB Injuries Right Arrow
    Team Stats

    29-64 (45%)
    Field Goals
    24-49 (49%)
    7-12 (58%)
    Free Throws
    24-34 (71%)
    10-36 (28%)
    3P
    8-21 (38%)
    33
    Rebounds
    30
    12
    Assists
    12
    11
    Turnovers
    9
    5
    Steals
    9
    3
    Blocks
    3
    23
    Fouls
    15

    Louisville vs. Clemson Odds Comparison

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    Louisville at Clemson Team Totals

    MatchupOverUnder
    Louisville
    20-8
    N/A
    N/A
    Clemson
    20-8
    N/A
    N/A