The New York Mets (7-16) host the Minnesota Twins (12-11) on April 22, 2026. First pitch from Citi Field is scheduled for 7:10 p.m. EDT. The game will be broadcast on SNY.
The Mets are favored by -158 on the moneyline and by -1.5 (+142) on the run line. The Twins are +134 on the moneyline and +1.5 (-172) on the run line. The total is set at 7.5 runs (-108 / -112)
Find my MLB picks and Twins vs Mets prediction below, as well as probable pitchers, weather report, and more.
Twins vs Mets Predictions, Pick
- Twins vs Mets Pick: Twins Moneyline (+134)
My Twins vs Mets best bet is on Minnesota to win outright. Make sure to find the best odds by checking our live MLB odds page.
Twins vs Mets Odds, Spread, Line
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -172 | 7.5 -108o / -112u | +134 |
| Mets Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +142 | 7.5 -108o / -112u | -158 |
- Twins vs Mets moneyline: Twins +134, Mets -158
- Twins vs Mets over/under: 7.5 (-108 / -112)
- Twins vs Mets spread: Mets -1.5 (+142), Twins +1.5 (-172)
Twins vs Mets Pitchers
| LHP Connor Prielipp (MIN) | Stat | RHP Clay Holmes (NYM) |
|---|---|---|
| Season debut | W-L | 2-2 |
| — | fWAR (FanGraphs) | 0.2 |
| — | ERA / xERA | 1.96/4.00 |
| — | FIP / xFIP | 4.18/4.07 |
| — | K-BB% | 7.5% |
| — | GB% | 58.2% |
| — | BABIP | .215 |
| — | Stuff+ | 100 |
| — | Location+ | 103 |
Twins vs Mets Expert MLB Pick
The Minnesota Twins head into the second game of their three-game set at Citi Field looking to keep the pressure on a New York Mets team currently mired in a historically difficult stretch.
After a 5-3 victory on Tuesday, the Twins find themselves in a favorable position, having handed New York their 12th consecutive loss.
The Mets’ recent slide is their longest since 2002, and the atmosphere in Queens is undeniably tense as the club struggles to regain its footing.
While the Mets are technically the hosts, the current momentum heavily favors the visitors, who have managed a respectable 5-5 road record this season.
For Wednesday’s matchup, all eyes will be on the return of superstar Juan Soto, who is expected to be activated from the injured list.
The Mets are desperate for his offensive production, as they have scored only 22 runs throughout their 12-game losing streak—a clear indicator of the void left by his absence since early April.
However, getting back on track against a Minnesota squad will be a tall order.
The Twins are turning to left-handed prospect Connor Prielipp, who will be recalled from Triple-A St. Paul to make his Major League debut on the mound.
While relying on a rookie in his first big league start is always a variable, the Mets’ current lack of offensive consistency makes it difficult to project a breakout performance from them, regardless of who is pitching for Minnesota.
The Mets will counter with veteran right-hander Clay Holmes, who holds a solid 1.96 ERA, but he will need to navigate a Twins lineup that has been opportunistic when it matters most, particularly in late-game situations like the one that decided Tuesday's contest.
How To Bet My Twins vs Mets Pick, Betting Analysis
Despite the Mets sending a seasoned pitcher like Clay Holmes to the hill and welcoming back a foundational piece in Juan Soto, the current betting value lies firmly with the Minnesota Twins on the moneyline.
When analyzing the betting landscape, we look to the "Road Dogs Interleague" system from Evan Abrams. Historical data since 2016 reveals that road underdogs in interleague matchups are consistently undervalued by the market. Despite a modest win percentage of 43.3% in these scenarios, these teams have generated a positive return on investment of 4.6%.
This system has proven reliable across five consecutive seasons, highlighting a distinct market inefficiency caused by a lack of familiarity between leagues and an inherent, often unjustified, public bias toward home teams.
In this specific matchup, the market may be overvaluing the Mets' potential for a "rebound" following the return of their star player.
However, given New York’s psychological state during this 12-game skid and the volatility that comes with a team under this level of pressure, the Twins represent the sharper side of the bet.
Backing the Minnesota Twins on the moneyline capitalizes on these systemic market inefficiencies and the reality that until the Mets prove they can consistently generate runs, they cannot be trusted as significant favorites.
Pick: Twins Moneyline (+134)
