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White Sox vs Orioles Prediction, Pick, MLB Odds for Monday, June 29

White Sox vs Orioles Prediction, Pick, MLB Odds for Monday, June 29 article feature image
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Pictured: Chicago White Sox left fielder Sam Antonacci. (Credit: Patrick Gorski-Imagn Images)

The Baltimore Orioles host the Chicago White Sox on June 29, 2026. First pitch from Oriole Park at Camden Yards is scheduled for 6:35 p.m. EDT. The game will be broadcast on MASN.

The Orioles are favored by -134 on the moneyline and by -1.5 on the run line. The White Sox are +114 on the moneyline and +1.5 on the run line. The total is set at 9 runs.

Find my MLB picks and White Sox vs Orioles prediction below, as well as probable pitchers, weather report, and more.


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White Sox vs Orioles Prediction

  • White Sox vs Orioles Pick: White Sox ML (+114)

My White Sox vs Orioles best bet is on Chicago to win outright. Make sure to find the best odds by checking our live MLB odds page.


White Sox vs Orioles Odds

White Sox Logo
Monday, Jun 29
6:35 p.m. ET
MASN
Orioles Logo
White Sox Odds
SpreadTotalMoneyline
+1.5
-188
9
-110o / -110u
+114
Orioles Odds
SpreadTotalMoneyline
-1.5
+155
9
-110o / -110u
-134
Odds via FanDuel. Get up-to-the-minute MLB odds here.
FanDuel Logo
  • White Sox vs Orioles moneyline: White Sox +114, Orioles -134
  • White Sox vs Orioles over/under: 9 (-110o / -110u)
  • White Sox vs Orioles spread: White Sox +1.5 (-188), Orioles -1.5 (+155)

White Sox vs Orioles Kalshi MLB Odds


White Sox vs Orioles Probable Pitchers

RHP Sean Burke (CHW)StatRHP Shane Baz (BAL)
5-4W-L4-8
1.3fWAR (FanGraphs)1.5
3.71/3.95ERA / xERA4.31/4.50
3.98/4.19FIP / xFIP3.83/4.38
15.7%K-BB%11.3%
34.2%GB%37.2%
.283BABIP.308
98Stuff+99
103Location+101

White Sox vs Orioles MLB Betting Preview

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White Sox vs Orioles Pick, Betting Analysis

The White Sox will hand the ball to young hurler Sean Burke in this series opener in Baltimore.

Burke has been a steadying force for the first-place White Sox, bolstering their rotation with a 3.71 ERA. To match his strong ERA, Burke also features a 3.95 xERA and 3.99 FIP.

The towering 6-6 frame of Burke helps his 94-97 mph fastball appear firmer. That's the go-to pitch for him, as he throws the heat 37% of the time. He also mixes in a cutter, slider, and sinker more than 15% of the time.

Offensively, Chicago has enjoyed a power surge in June, ranking seventh in home runs and eighth in ISO. They lag in some other key areas, such as in strikeout rate (24%) and walk rate (8%). Their shaky plate approach is indicative of the White Sox's youth.

The pair of Sam Antonacci and Miguel Vargas has carried this Chicago lineup. Antonacci leads the squad with a 165 wRC+ in June, while Vargas has connected on five long balls.

The Orioles gave up a haul to pry Shane Baz away from the Rays, but it's been a bad trade for Baltimore thus far. Baz owns a 4.31 ERA with a 4.50 xERA and 3.84 FIP. I expected Baz to make a jump for Baltimore if he was able to stay healthy, but his K/9 dipped to 7.76, which should be one of his strengths.

Baz made real strides in the long-ball department, cutting his HR/9 in half from 1.41 to 0.86. However, teams are still hitting him hard, as he sits in the 22nd percentile in average exit velocity and 35th in hard hit rate.'

I think "streaky" is the perfect word to describe Baz. He's always capable of a five- or six-run implosion, but he's equally capable of tossing seven innings of one-run ball. You just never know which version of Baz shows up.

The Orioles' offense has disappeared in June, ranking 18th with a 104 wRC+. They have a 25% strikeout rate in that span, the third-worst in the league, but also walk at the 11th-best clip.

The duo of Pete Alonso and Gunnar Henderson was supposed to guide this Baltimore team. That hasn't been the case, though.

Alonso, who started the season slowly, caught fire this month, leading the team with a 168 wRC+ and seven homers. Henderson, however, has a 108 wRC+, which is up from his woeful 97 on the season.

There needs to be an adjustment made for this Orioles offense with this version of Henderson in the mix. It just isn't a top-10 unit in the sport if Henderson is a below league-average bat.

Orioles fans can breathe a little easier late in games now with Ryan Helsley back in the fold. With him shutting the door in the ninth, it allows Yennier Cano and Rico Garcia to occupy the 7th and 8th innings and shorten games. If Baz goes a strong six, Baltimore has to feel decent about its chances.

That said, I'm rolling with the White Sox here. I know Chicago is 27-13 at home compared to 15-25 on the road, but this matchup lines up nicely for them.

I give them the edge in the pitching matchup with Burke over Baz. The upside of both lineups favors the Orioles because of what Alonso, Henderson, and Samuel Basallo can accomplish. That said, I view the White Sox lineup as one that is more consistent and can take advantage of Baz's very hittable fastball.

Pick: White Sox ML (+114)


White Sox vs Orioles Weather


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