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Orioles vs. Red Sox Odds & Betting Predictions - July 22, 2026

Orioles at Red Sox

5:35 pm • NESN

Baltimore Orioles

49-52
@

Boston Red Sox

51-48
Starting Pitchers
pitcherteameraw-l
Jake Bennett logoJ.BennettBoston Red Sox logo2.355-3
Dean Kremer logoD.KremerBaltimore Orioles logo4.151-2

Orioles at Red Sox Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Orioles
49-52
+1.5
+1.5-150
o9.5-105
+138
Red Sox
51-48
u9.5
-1.5+125
u9.5-115
-164
location pinWednesday 5:35 p.m.
July 22, 2026
Fenway ParkBoston
thermometer image84°Fahrenheit
rain image32%Rain
wind image11Wind
Orioles vs. Red Sox Expert Picks
Austin Pendergrass
Austin Pendergrass
Last 30d: 41-21-3 (+9.5u)
BOS -144
0.5u
Matthew Lopes
Matthew Lopes
Last 30d: 41-167-3 (-19.6u)
W.Contreras To Hit 1+ Home Runs Yes+300
1u
W.Abreu To Hit 1+ Home Runs Yes+335
1u
Frank Ammirante
Frank Ammirante
Last 30d: 331-373-6 (-39.0u)
J.Bennett u1.5 BB-125
1.25u
Under 9.5-110
1.1u
Zense
Zense
Last 30d: 25-23-4 (-1.0u)
BOS -140
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 75-86-0 (+11.6u)
BAL +142
1u
Wags Wins
Wags Wins
Last 30d: 199-179-4 (+6.8u)
BOS -1.5+145
1u
Adam Kaufman
Adam Kaufman
Last 30d: 122-107-3 (+9.6u)
BOS -140
1.4u
OldSchool0909
Last 30d: 31-33-0 (+5.1u)
BAL +120
1u

Orioles vs. Red Sox Previews & Analysis

  • Derek Carty's 4 MLB Player Props for Wednesday article feature image

    Derek Carty's 4 MLB Player Props for Wednesday

    Action Network Staff•
    Jul 22, 2026 UTC
  • Carty's Prop Pick for Orioles vs Red Sox Game 1 article feature image

    Carty's Prop Pick for Orioles vs Red Sox Game 1

    Action Network Staff•
    Jul 22, 2026 UTC
  • Opening Pitch: Zerillo's MLB Projections for Wednesday via BARTOLO article feature image

    Opening Pitch: Zerillo's MLB Projections for Wednesday via BARTOLO

    Sean Zerillo•
    Jul 21, 2026 UTC
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Prop Odds Comparison

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No props found

Line Movement Tracker

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Orioles vs. Red Sox Public Betting Percentages

Away Logo

Orioles

Public

Home Logo

Red Sox

16%

Bets%

84%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Red Sox are 5-0 in their last 5 games.
  • Red Sox are 4-1 in their last 5 games against the spread
  • Red Sox are 26-24 in their road games against the spread
  • The totals have gone OVER in 3 of Red Sox' last 5 games
  • The totals have gone OVER in 20 of Red Sox' 49 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Red Sox		47-5221-2826-2428-3518-17
Orioles		50-5127-2623-2523-2826-23

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Red Sox		45-50-420-26-325-24-130-30-315-19-1
Orioles		53-45-327-24-226-21-124-25-229-19-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Red Sox		51-4822-2729-2132-3118-17
Orioles		49-5228-2521-2726-2522-27

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jul 20thBALW 6-5-1.5 LO 8.5BOS -166
Jul 19thTBW 6-1-1.5 WU 8.5BOS -125
Jul 18thTBW 7-6+1.5 WO 9.5BOS -119
Jul 17thTBW 5-3-1.5 WU 9BOS -131
Jul 17thTBW 10-0+1.5 WO 8.5BOS -118

Orioles vs. Red Sox Injury Updates

Orioles Injuries

  • Heston Kjerstad
    LF

    Kjerstad is out with hamstring

    Out

  • Jordan Westburg
    3B

    Westburg is out with elbow

    Out

Red Sox Injuries

  • Tanner Houck
    SP

    Houck is out with arm

    Out

  • Triston Casas
    1B

    Casas is out with knee

    Out

  • Kutter Crawford
    SP

    Crawford is out with wrist

    Out

See more MLB Injuries Right Arrow
Orioles vs. Red Sox Starting Lineups
Orioles Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Dean Kremer logoRD.Kremer, P1-24.151.11510.04
HITTERSAVGOBPSLGHR
Taylor Ward logo1T.Ward, LF.251.386.3617
Pete Alonso logo2P.Alonso, 1B.246.347.46021
Gunnar Henderson logo3G.Henderson, SS.224.293.40217
Tyler O'Neill logo4T.O'Neill, RF.205.297.3606
Coby Mayo logo5C.Mayo, DH.196.264.40013
Leody Taveras logo6L.Taveras, CF.240.320.3634
Christian Encarnacion-Strand logo7C.Encarnacion-Strand, 3B.375.375.7501
Jackson Holliday logo8J.Holliday, 2B.205.322.3625
Sam Huff logo9S.Huff, C.138.167.2070
Red Sox Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Jake Bennett logoLJ.Bennett, P5-32.350.8766.37
HITTERSAVGOBPSLGHR
Masataka Yoshida logo1M.Yoshida, DH.267.341.3984
Ceddanne Rafaela logo2C.Rafaela, CF.281.326.4338
Wilyer Abreu logo3W.Abreu, RF.267.339.46115
Willson Contreras logo4W.Contreras, 1B.289.384.55722
Caleb Durbin logo5C.Durbin, 3B.236.299.40010
Romy Gonzalez logo6R.Gonzalez, 2B.184.273.3061
Jarren Duran logo7J.Duran, LF.191.254.34013
Connor Wong logo8C.Wong, C.277.374.3701
Tsung-Che Cheng logo9T.Cheng, SS.278.341.3060

Orioles vs. Red Sox Odds Comparison

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Orioles at Red Sox Team Totals

MatchupOverUnder
Orioles
49-52
N/A
N/A
Red Sox
51-48
N/A
N/A