Mariners vs. Astros Odds & Betting Predictions - September 21, 2025

Mariners at Astros

11:10 pm • ESPN

Seattle Mariners

7

7 - 3

Houston Astros

3

pitcher		team	era	w-l
J.Alexander			3.66	4-2
L.Gilbert			3.44	6-6

MatchupOpenSpreadTotalMoneyline
Mariners 0-0	-1.5	-1.5+110	o8.5-105	-149
Astros 0-0	u8	+1.5-137	u8.5-115	+122

location pin

Sunday 11:10 p.m.

September 21, 2025

Daikin ParkHouston

SEA -130

1.54u

Mariners vs Astros: Expect a Tight Sunday Night Battle
Nick Martin•
Sep 21, 2025 UTC

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MLB Public Betting

Astros are 3-2 in their last 5 games.
Astros are 3-2 in their last 5 games against the spread
Astros are 45-36 in their road games against the spread
The totals have gone OVER in 1 of Astros' last 5 games
The totals have gone OVER in 36 of Astros' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Astros	82-80	37-44	45-36	43-60	39-18
Mariners	69-93	36-45	33-48	44-69	24-22

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Astros	72-83-7	36-43-2	36-40-5	45-56-2	25-27-5
Mariners	88-68-6	41-35-5	47-33-1	58-49-6	28-18

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Astros	87-75	46-35	41-40	56-47	31-26
Mariners	90-72	51-30	39-42	66-47	22-24

date	opponent	score	spread	over/under	moneyline
Sep 20th	SEA	L 4-6	+1.5 L	O 8	SEA -109
Sep 20th	SEA	L 0-4	+1.5 L	U 7.5	SEA -111
Sep 18th	TEX	W 5-2	+1.5 W	U 7.5	HOU +122
Sep 17th	TEX	W 6-5	+1.5 W	O 7.5	HOU +100
Sep 16th	TEX	W 6-3	-1.5 W	O 8.5	HOU -132

Dominic Canzone
OF
Dominic Canzone scratched Sunday.
Out

Pedro Leon
OF
Leon is out with knee
Out
Hayden Wesneski
P
Wesneski is out with elbow
Out

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PITCHER		PC	IP	K	ER
RL.Gilbert, P		91	6	4	1
LC.Ferguson, P		13	0.1	0	1
RC.Vargas, P		20	1.2	1	1
RM.Brash, P		11	1	1	0

HITTERS	H-AB	R	HR	RBI
1R.Arozarena, LF	1-4	1	0	0
2C.Raleigh, C	1-4	1	1	2
3J.Rodriguez, CF	1-4	0	0	0
4J.Naylor, 1B	2-4	0	0	0
5J.Polanco, 2B	1-4	1	0	0
5L.Rivas, 2B	0-0	0	0	0
6E.Suarez, 3B	1-3	1	0	0
7D.Canzone, DH	0-3	1	0	0
7M.Garver, PH	0-1	0	0	0
7M.Garver, DH	0-1	0	0	0
8V.Robles, RF	0-3	1	0	1
9J.Crawford, SS	1-4	1	1	4

PITCHER		PC	IP	K	ER
RJ.Alexander, P		37	1.1	1	7
RE.De Los Santos, P		14	1.2	1	0
RA.Blubaugh, P		34	3	1	0
RC.Kimbrel, P		20	1	3	0
RN.Hernandez, P		18	1	1	0
LB.King, P		11	1	0	0

HITTERS	H-AB	R	HR	RBI
1J.Altuve, 2B	2-3	0	0	1
2C.Correa, 3B	0-4	0	0	0
3I.Paredes, DH	1-4	1	1	1
4J.Sanchez, LF	0-4	0	0	0
5C.Walker, 1B	1-4	0	0	0
6Y.Diaz, C	0-4	0	0	0
7J.Meyers, CF	0-4	0	0	0
8Z.Cole, RF	2-4	2	1	1
9M.Dubon, SS	1-3	0	0	0
9V.Caratini, PH	0-1	0	0	0

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MatchupOverUnder
Mariners 0-0	o4.5-110	u4.5-117
Astros 0-0	o3.5-111	u3.5-116