Cardinals vs. Cubs Odds & Betting Predictions - September 27, 2025

Cardinals at Cubs

6:20 pm • FDSMW

St. Louis Cardinals

3

3 - 7

Chicago Cubs

7

pitcher		team	era	w-l
J.Taillon			3.68	11-7
M.McGreevy			4.42	8-4

MatchupOpenSpreadTotalMoneyline
Cardinals 40-34	+1.5	+1.5-133	o9.5-107	+150
Cubs 40-36	u9	-1.5+110	u9.5-113	-178

location pin

Saturday 6:20 p.m.

September 27, 2025

Wrigley FieldChicago

Under 9.5-110

0.55u

Under 9.5-115

0.58u

Bet to 9 (-105)

No props found

MLB Public Betting

Cubs are 3-2 in their last 5 games.
Cubs are 2-3 in their last 5 games against the spread
Cubs are 15-22 in their road games against the spread
The totals have gone OVER in 2 of Cubs' last 5 games
The totals have gone OVER in 20 of Cubs' 39 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cubs	29-47	14-25	15-22	19-33	10-14
Cardinals	44-30	22-16	22-14	9-7	35-22

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cubs	39-37	20-19	19-18	25-27	14-10
Cardinals	32-38-4	17-19-2	15-19-2	6-9-1	25-29-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cubs	40-36	23-16	17-20	29-23	11-13
Cardinals	40-34	21-17	19-17	11-5	29-28

date	opponent	score	spread	over/under	moneyline
Sep 26th	STL	W 12-1	-1.5 W	O 9	CHC -184
Sep 25th	NYM	L 5-8	+1.5 L	O 7.5	NYM -103
Sep 25th	NYM	W 10-3	+1.5 W	O 7.5	CHC -118
Sep 23rd	NYM	L 7-9	+1.5 L	O 7.5	NYM +100
Sep 21st	@CIN	L 0-1	+1.5 W	U 9	CIN +105

Tyler Austin
1B
Austin is out with knee
Out
Justin Steele
SP
Steele is out with elbow
Out

See more MLB Injuries

PITCHER		PC	IP	K	ER
RM.McGreevy, P		88	4.2	3	3
LJ.King, P		6	0.1	0	0
RR.Fernandez, P		19	1	2	2
RM.Svanson, P		14	1	2	0
RJ.Alcala, P		28	1	1	2

HITTERS	H-AB	R	HR	RBI
1L.Nootbaar, LF	0-3	0	0	0
2I.Herrera, DH	1-4	0	0	0
3A.Burleson, 1B	0-4	0	0	0
4N.Arenado, 3B	2-4	1	1	1
5N.Gorman, 2B	1-4	0	0	0
6T.Saggese, SS	0-4	0	0	0
7J.Crooks, C	2-4	1	0	0
8J.Walker, RF	1-2	1	1	2
9V.Scott, CF	0-2	0	0	0
9J.Fermin, PH	0-1	0	0	0
9N.Church, CF	0-1	0	0	0

PITCHER		PC	IP	K	ER
RJ.Taillon, P		83	6	8	1
LC.Thielbar, P		15	1	2	2
LD.Pomeranz, P		11	1	2	0
RB.Keller, P		26	1	1	0

HITTERS	H-AB	R	HR	RBI
1M.Busch, 1B	4-4	2	2	4
2N.Hoerner, 2B	0-5	0	0	0
3I.Happ, LF	1-4	0	0	0
4K.Tucker, DH	0-4	0	0	0
5S.Suzuki, RF	1-2	2	1	1
6C.Kelly, C	1-4	0	0	0
7P.Crow-Armstrong, CF	2-4	1	1	2
8D.Swanson, SS	1-3	0	0	0
9M.Shaw, 3B	0-3	2	0	0

Could not load odds

See more MLB Odds

MatchupOverUnder
Cardinals 40-34	N/A	N/A
Cubs 40-36	N/A	N/A