Astros vs. Cubs Odds & Betting Predictions - May 24, 2026

Astros at Cubs

6:20 pm • SCHN
8 - 5
Starting Pitchers
pitcherteameraw-l
Shota Imanaga logoS.ImanagaChicago Cubs logo3.384-4
Peter Lambert logoP.LambertHouston Astros logo3.572-4

Astros at Cubs Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
22-31
+1.5
+1.5-158
o7-108
+140
Cubs
29-23
u8
-1.5+136
u7-114
-170
location pinSunday 6:20 p.m.
May 24, 2026
Wrigley FieldChicago
Astros vs. Cubs Expert Picks
Derek Carty
Derek Carty
Last 30d: 25-48-4 (+3.5u)
C.Kelly o0.5 HR+1236
0.25u
There may be some value on Carson Kelly's home runs prop. THE BAT X is projecting him to record 0.11 home runs, and oddsmakers are implying 0.08. The model believes there is a 10% chance he records at least 1 home run, so there is value on the over at +1236. This play is good down to at least +995. Love THE BAT X? Get all of Carty's sports betting projections at EV Analytics https://evanalytics.com/subscribe/mlb?ref=zdlkmgz
Grant Neiffer
Grant Neiffer
Last 30d: 26-113-7 (+1.3u)
C.Walker o0.5 HR+500
1.25u
Frank Ammirante
Frank Ammirante
Last 30d: 239-263-10 (-10.0u)
CHC -1.5+130
0.77u
S.Imanaga u4.5 Hits Allowed-110
1.1u
Under 7.5-123
1u
Adam Kaufman
Adam Kaufman
Last 30d: 41-49-0 (-13.2u)
HOU +146
1.46u
Sean Zerillo
Sean Zerillo
Last 30d: 175-145-12 (+6.1u)
Under 7.5-115
0.58u
Bet to 7 (-115)
CHC -165
0.83u
Bet to -195

Astros vs. Cubs Previews & Analysis

  • Neiffer's 4 Home Run Props for Sunday article feature image

    Neiffer's 4 Home Run Props for Sunday

    Grant Neiffer
    May 24, 2026 UTC
  • Astros vs Cubs: Carty's Prop for Sunday article feature image

    Astros vs Cubs: Carty's Prop for Sunday

    Action Network Staff
    May 24, 2026 UTC
  • The Leadoff: Minion's MLB Breakdown and Bets for Sunday article feature image

    The Leadoff: Minion's MLB Breakdown and Bets for Sunday

    Ryan Minion
    May 24, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Astros vs. Cubs Public Betting Percentages

Away Logo

Astros

Public

24%

Bets%

76%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cubs
21-3112-169-1514-207-11
Astros
22-3111-1511-164-1118-19

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cubs
28-2414-1414-1017-1711-7
Astros
27-22-416-9-111-13-39-617-16-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cubs
29-2318-1011-1321-138-10
Astros
22-3112-1410-175-1017-20

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 23rdHOUL 0-3-1.5 LU 7HOU -149
May 22ndHOUL 2-4-1.5 LU 7HOU -149
May 20thMILL 0-5+1.5 LU 6.5MIL -112
May 19thMILL 2-5+1.5 LU 7.5MIL +103
May 18thMILL 3-9-1.5 LO 10.5MIL -161

Astros vs. Cubs Injury Updates

Astros Injuries

  • Lance McCullers
    SP

    Lance McCullers Jr. has been scratched Tuesday. Jason Alexander will start.

    Out

Cubs Injuries

  • Tyler Austin
    1B

    Austin is out with knee

    Out

  • Justin Steele
    SP

    Steele is out with elbow

    Out

  • Jordan Wicks
    SP

    Wicks is out with arm

    Out

Astros vs. Cubs Box Score
Astros Player Stats
Projected
PITCHERPCIPKER
Peter Lambert logoRP.Lambert, P103553
AJ Blubaugh logoRA.Blubaugh, P29202
Bryan Abreu logoRB.Abreu, P15100
Nate Pearson logoRN.Pearson, P20100
HITTERSH-ABRHRRBI
Brice Matthews logo1B.Matthews, 2B0-5000
Brice Matthews logo1B.Matthews, LF0-5000
Jeremy Pena logo2J.Pena, SS1-4102
Christian Walker logo3C.Walker, 1B1-4113
Isaac Paredes logo4I.Paredes, DH2-4000
Jake Meyers logo5J.Meyers, CF1-4111
Cam Smith logo6C.Smith, RF1-3200
Zach Dezenzo logo7Z.Dezenzo, LF0-2100
Braden Shewmake logo7B.Shewmake, 3B0-0000
Christian Vazquez logo8C.Vazquez, C0-4000
Nick Allen logo9N.Allen, 3B3-3212
Nick Allen logo9N.Allen, 2B3-3212
Cubs Player Stats
Projected
PITCHERPCIPKER
Shota Imanaga logoLS.Imanaga, P94667
Ethan Roberts logoRE.Roberts, P16110
Phil Maton logoRP.Maton, P13100
Caleb Thielbar logoLC.Thielbar, P13111
HITTERSH-ABRHRRBI
Pete Crow-Armstrong logo1P.Crow-Armstrong, CF0-1101
Nico Hoerner logo2N.Hoerner, SS1-5001
Michael Busch logo3M.Busch, 1B2-4112
Alex Bregman logo4A.Bregman, 3B1-4000
Michael Conforto logo5M.Conforto, LF0-4000
Seiya Suzuki logo6S.Suzuki, RF0-4000
Moises Ballesteros logo7M.Ballesteros, DH0-2100
Carson Kelly logo8C.Kelly, C2-4100
Kevin Alcantara logo8K.Alcantara, PR0-0000
Miguel Amaya logo8M.Amaya, C0-0000
Pedro Ramirez logo9P.Ramirez, 2B1-3101

Astros vs. Cubs Odds Comparison

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Astros at Cubs Team Totals

MatchupOverUnder
Astros
22-31
N/A
N/A
Cubs
29-23
N/A
N/A