The Detroit Lions (1-1) and ArizonaCardinals (1-1) will play late Sunday afternoon of NFL Week 3. Kickoff is set for 4:25 p.m. ET from State Farm Stadium in Glendale, Ariz. The game will be broadcast live on FOX and can be streamed on YouTube TV and the FOX Sports app.
The Lions are consensus 3-point favorites with the over/under set at 51.5 across the board, which is the highest of Week 3. Detroit is a -155 favorite on the moneyline, while Arizona is +130 to pull off the upset.
The Lions have been unconvincing to start the season through two home games, beating the Rams 26-20 in OT in Week 1 and falling to the Bucs 20-16 last week. Jared Goff hasn't gotten going, and the Detroit offense has especially struggled in the red zone so far. Arizona, meanwhile, has showed tons of promise so far this season, coming within a score of knocking off the Bills in a 34-28 loss in Week 1. Kyler Murray is playing like an MVP candidate, while Marvin Harrison Jr. broke out with two touchdowns last week in a 41-10 win over the Rams.
Let's get into my Lions vs. Cardinals predictions and my NFL picks for Week 3 on Sunday.
Lions vs. Cardinals Odds, Picks, Prediction
| Lions Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3 -105 | 51.5 -108o / -112u | -148 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3 -115 | 51.5 -108o / -112u | +124 |
- Lions vs. Cardinals spread: Lions -3
- Lions vs. Cardinals over/under: 51.5 points
- Lions vs. Cardinals moneyline: Lions -155, Cardinals +130
- Lions vs. Cardinals pick: Lions -3
My Cardinals vs. Lions best bet is on the Lions to cover the spread. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
Spread
My expert pick is on the spread, backing Detroit.
Moneyline
I do not have a pick on the moneyline.
Over/Under
I also am not touching this over/under, the largest in Week 3.
My Pick: Lions -3 (-105)
Detroit Lions vs. Arizona Cardinals NFL Week 3
By Matt Trebby
Kyler Murray has been electric this season. The speedster's stats jump off the page through two games.
Murray is completing 73.1% of passes so far this season on 8.2 yards per attempt. He has four touchdowns to no interceptions, and he has also run for 116 yards.
Marvin Harrison Jr. broke out in Week 2 with two touchdowns against the Rams. He's Arizona's leading receiver through two games, although tight end Trey McBride leads the team with 11 receptions and 15 targets.
The Lions have not hit their stride on offense so far this season, although the ground game has been stout. David Montgomery has 126 rushing yards and Jahmyr Gibbs has 124.
Jared Goff and the passing game is what has held Detroit back. Goff has just one touchdown pass to three interceptions and is averaging 6.3 yards per attempt, which would be the lowest of his career since he started the 2017 season as the Rams' starting QB.
Both offenses have the edge here. Specifically, the Lions will look to attack the Cardinals secondary since the run defense has been elite so far this season, while the Lions also have been great against the run.
I like the under here, but I’m focused on backing the Lions. There are a few trends that have me looking to bet on Detroit, specifically Dan Campbell.
In Weeks 1-3 under Campbell, the Lions are 8-3 against the spread (ATS) and 15-9 ATS as a favorite overall. Also, as a head coach, Campbell is 17-9 ATS coming off of a loss as the Lions' head coach.
I like the Lions at -3, but I love them at -2.5 if you can get that number. You can always buy the one-half point.
Pick: Lions -3 (-105)
Cardinals vs. Lions Betting Trends
- 58% of bets and 55% of the money are on the Cardinals to cover the spread.
- 47% of bets and 64% of the money are on the over.
- 66% of bets and 41% of the money on the moneyline are on the Lions.
How to Watch: Time, Channel, Streaming
| Location: | State Farm Stadium |
| Date: | Sunday, Sept. 22 |
| Kickoff Time: | 4:25 p.m. ET |
| TV / Streaming: | FOX |
Cardinals vs. Lions is scheduled for 4:25 p.m. ET, live from State Farm Stadium in Glendale, Ariz. The game is on TV on FOX and can be streamed on platforms like YouTube TV.
NFL Weather Sunday
For more on NFL weather for Week 3, click here.
