The Buffalo Bills (10-3) and Detroit Lions (12-1) square off in NFL Week 15 at 4:25 p.m. ET from Ford Field in Detroit. The game will be broadcast on CBS and can be streamed on Paramount+.
Bills vs Lions odds (via Caesars) have the Lions as -140 moneyline favorites and Bills as +118 underdogs. The over/under is 55.5 total points (-110/-110). The Lions are 2-point favorites over the Bills on the spread (-2).
Let's get into my Bills vs Lions predictions and picks for Week 15, plus the latest odds, NFL betting trends, injury reports and more.
Bills vs Lions Predictions
Spread
I see value on the Bills at +2.5, although I'm hoping this number gets to +3. Still, I'll back the Bills here in a matchup that I think benefits them.
Over/Under
I project this game's total at 54.5, which is crazy. With that, I see no value on either side of this matchup, which has the highest over/under of the season at 55.
My Pick: Bills +2.5 (-110)
Bills vs Lions Odds
| Bills Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2 -105 | 55.5 -110o / -110u | +118 |
| Lions Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2 -115 | 55.5 -110o / -110u | -140 |
- Bills vs Lions Spread: Bills +2 (-105), Lions -2 (-115)
- Bills vs Lions Total: Over/under 55.5 (-110/-110)
- Bills vs Lions Moneyline: Bills +118, Lions -140
- Bills vs Lions Pick: Bills +2.5 (-110)
MyBills vs Lions best bet is on Buffalo to cover the spread. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
Bills vs Lions Preview & Prediction for NFL Week 15
I’m hoping we get to Bills +3 on the spread. Getting a field goal on the road with Buffalo would be great.
I’ve been jonesing for this spot to fade the Lions because I’ve been waiting for a top-tier quarterback and healthy offense to face their defense. Detroit has been fortunate with its matchups this season, and this defense could get picked apart.
The Lions defense plays aggressive man coverage, and its single-high-safety looks could get picked apart by Josh Allen. We hear often about how Jared Goff thrives indoors, but Allen is 9-2-1 against the spread (ATS) in his career when playing indoors. He covers at an 81.8% rate and by 10 points per game.
The Bills play a ton of zone defense and don’t blitz much. That’s what you want to do against a Lions offense that is going to have success running the ball.
The Lions have struggled against mobile quarterbacks this season, and Allen is among the most mobile in the NFL. He’ll be very active using his legs here, and that will create explosive plays for the Bills offense.
Allen is the best quarterback the Lions have faced this season. They have one loss and are 6-1 against the spread in one-possession games. They blew out Mac Jones, Mason Rudolph and Anthony Richardson. This is a step up that the Lions haven’t seen this season.
By the way, Allen is 27-14-2 (66%) ATS when he’s an underdog or favorite of fewer than three points. On the road, he’s 18-8-2 in that situation.
Teams with a win percentage north of 90% in December are 21-48-2 since 2003. That’s a 30% rate, and those teams fail to cover by 3.5 points per game.
Also, teams averaging more than 28 points per game with a win percentage north of 90% are 8-31-2 against the spread in December.
I love this matchup for the Bills on both sides of the ball. I think Goff will make a mistake or two that will cost Detroit and allow the Bills to bounce back after a tough loss to the Rams.
My Pick: Bills +2.5
Bills vs Lions Betting Trends
Bills Trends
- Bills are 4-1 in their last 5 games against the spread
- Bills are 4-3 in their road games against the spread
- The totals have gone OVER in 2 of Bills' last 5 games
Lions Trends
- Lions are 4-1 in their last 5 games against the spread
- The totals have gone OVER in 2 of Lions' last 5 games
- The totals have gone OVER in 4 of Lions' 7 last games at home
Bills vs Lions Latest Injuries
Bills Injuries
| Player | Status |
|---|---|
| CB Rasul Douglas | Out (knee) |
| T Tylan Grable | Out (groin) |
| S Damar Hamlin | Questionable (back/ribs) |
| TE Dalton Kincaid | Questionable (knee) |
| TE Quintin Morris | Questionable (shoulder/groin) |
| S Taylor Rapp | Questionable (neck/shoulder) |
| DE Dawuane Smoot | Questionable (wrist) |
| LB Baylon Spector | Questionable (calf) |
| DE Casey Toohill | Questionable (ribs) |
Lions Injuries
| Player | Status |
|---|---|
| LB Trevor Nowaske | Out (concussion) |
Bills vs Lions Weather
