The Wake Forest Demon Deacons take on the Virginia Cavaliers in Charlottesville, Virginia. Kickoff is set for 7:00 p.m. EST on ESPN.
Virginia is favored by 6.5 points on the spread with a moneyline of -250. The total is set at 48.5 points.
Here’s my Wake Forest vs. Virginia prediction and college football picks for Saturday, November 8, 2025.
Wake Forest vs Virginia Prediction
- Wake Forest vs. Virginia Pick: Wake Forest +7 or Better
My Virginia vs. Wake Forest best bet is on the Demon Deacons. Find the best line available on our live NCAAF odds page.
Wake Forest vs Virginia Odds, Spread, Line
| Wake Forest Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6.5 -105 | 48.5 -105o / -115u | +200 |
| Virginia Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6.5 -115 | 48.5 -105o / -115u | -250 |
- Wake Forest vs Virginia Spread: Virginia -6.5 (-115), Wake Forest +6.5 (-105)
- Wake Forest vs Virginia Totals: 48.5 (O -105 / U -115).
- Wake Forest vs Virginia Moneyline: Wake Forest +200, Virginia -250
Stuckey's Wake Forest vs Virginia Betting Analisys
For starters, on the season, Wake has played the slightly more difficult schedule and has a superior net yards per play mark (+0.5 to +0.4). Why? It's the defense, which ranks among the top 10 when adjusted for opponent.
Last week, the Demon Deacons had a disappointing effort in Tallahassee, but I think a lot of that had to do with a poor matchup and a tough situational spot, where I happily faded them.
I'm happy to buy low here at a touchdown or better against a completely fraudulent Virginia team that somehow has eight wins on the season, but in reality, should have the same number as Wake (5).
The Hoos' first three wins of the season came against Stanford, William & Mary, and a brand-new Coastal Carolina club. Take a look at their past five victories since taking on real competition:
- Louisville by 3 in OT thanks to two defensive touchdowns (outgained, 383-237)
- Florida State in double overtime (outgained, 514-440)
- North Carolina by 1 in OT (outgained, 353-259)
- Washington State by 2 on a last-second safety (outgained, 318-301)
- Cal by 10 (last-second pick-six to win by margin and cover)
They could easily have gone 1-4 in that stretch with four of the five games going to overtime despite a +8 turnover margin. They deserved the Cal win, but should have only won by a field goal.
Despite sitting all alone in first place in the ACC, I don't even have Virginia power-rated as a top-50 team in the country.
While the Wake Forest offense is nothing to write home about, it should have some success running the ball on early downs this week, which is paramount for it to have any shot at sustaining drives.
The red-zone offense is downright dreadful, which is definitely a concern, but the Hoos have been very vulnerable in short-yardage and goal-line situations on defense.
They also struggle to contain opposing mobile quarterbacks, which could be an issue in this matchup.
Wake has a terribly inefficient passing attack that will make you want to pull your hair out while watching, but it can hit explosives (top-10 in that department), which is an area where teams can exploit Virginia's defense.
Most importantly, UVA just hasn't proven it can get a margin on any team with even a faint pulse.
With Duke on deck in a game that will likely determine who goes to the ACC Championship, it's also possible the Hoos come into this one with a bit of a lack of focus to boot.
Regardless, the offense has been solved for the most part, and the defense isn't anything special.
Wake will have the best unit on the field with its defense. I just don't see much separating these teams outside of their records, so I'm happy to take a touchdown on the road against a Virginia team traveling back across the country.
Pick: Wake Forest +7 or Better
