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West Virginia vs. Clemson Odds & Betting Predictions - November 21, 2025

West Virginia at Clemson

11:30 pm • ESPNU

West Virginia Mountaineers

18-14
67
67 - 70

Clemson Tigers

24-10
70

West Virginia at Clemson Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
West Virginia
18-14
+3.5-112
o132.5-112
+143
Clemson
24-10
u133.5
-3.5-108
u132.5-105
-171
location pinFriday 11:30 p.m.
November 21, 2025
TD ArenaCharleston
West Virginia vs. Clemson Expert Picks
Wags Wins
Wags Wins
Last 30d: 276-246-2 (+35.9u)
WVU +3.5-110
1.14u
💰🦡 Jake
💰🦡 Jake
Last 30d: 63-77-1 (-3.8u)
WVU u64.5-114
1.71u
Doug Ziefel
Doug Ziefel
Last 30d: 138-152-3 (-12.4u)
CLEM -3.5-105
0.53u

West Virginia vs. Clemson Previews & Analysis

  • West Virginia vs Clemson: Total Pick for Friday Night article feature image

    West Virginia vs Clemson: Total Pick for Friday Night

    John Feltman•
    Nov 21, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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West Virginia vs. Clemson Public Betting Percentages

Away Logo

West Virginia

Public

Home Logo

Clemson

63%

Bets%

37%

Money%

NCAAB Public Betting Right Arrow

Betting Trends

  • Clemson are 3-2 in their last 5 games.
  • Clemson are 1-4 in their last 5 games against the spread
  • Clemson are 9-6 in their road games against the spread
  • The totals have gone OVER in 2 of Clemson' last 5 games
  • The totals have gone OVER in 7 of Clemson' 19 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Clemson		18-169-109-614-144-2
West Virginia		15-1710-105-77-97-7

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Clemson		14-207-127-812-162-4
West Virginia		10-225-155-73-136-8

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Clemson		24-10N/AN/A23-51-5
West Virginia		18-14N/AN/A11-55-9

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 18thUNAW 81-61-25.5 LU 144.5CLEM -9000
Nov 15th@GTWNL 74-79-1.5 LO 142.5GTWN -117
Nov 12thMOREW 83-56-29.5 LU 151.5CLEM -6500
Nov 8thWEBBW 97-59---
Nov 4thUNHW 88-38-29.5 WU 146.5CLEM -20000

West Virginia vs. Clemson Injury Updates

West Virginia Injuries

    Clemson Injuries

    • Carter Welling
      F

      Welling is out with knee

      Out

    • Zac Foster
      G

      Foster is out for season with knee

      Out for Season

    See more NCAAB Injuries Right Arrow
    Team Stats

    23-57 (40%)
    Field Goals
    24-52 (46%)
    12-19 (63%)
    Free Throws
    15-19 (79%)
    9-23 (39%)
    3P
    7-22 (32%)
    29
    Rebounds
    32
    9
    Assists
    12
    7
    Turnovers
    11
    8
    Steals
    5
    3
    Blocks
    4
    17
    Fouls
    15

    West Virginia vs. Clemson Odds Comparison

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    West Virginia at Clemson Team Totals

    MatchupOverUnder
    West Virginia
    18-14
    N/A
    N/A
    Clemson
    24-10
    N/A
    N/A