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West Virginia vs. Clemson Odds & Betting Predictions - November 21, 2025

West Virginia at Clemson

11:30 pm • ESPNU

West Virginia Mountaineers

16-11
67
67 - 70

Clemson Tigers

20-8
70

West Virginia at Clemson Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
West Virginia
16-11
+3.5-112
o132.5-112
+143
Clemson
20-8
u133.5
-3.5-108
u132.5-105
-171
location pinFriday 11:30 p.m.
November 21, 2025
TD ArenaCharleston
West Virginia vs. Clemson Expert Picks
Wags Wins
Wags Wins
Last 30d: 219-230-0 (-23.4u)
WVU +3.5-110
1.14u
💰🦡 Jake
💰🦡 Jake
Last 30d: 104-101-1 (+38.1u)
WVU u64.5-114
1.71u
Doug Ziefel
Doug Ziefel
Last 30d: 150-175-1 (-11.6u)
CLEM -3.5-105
0.53u

West Virginia vs. Clemson Previews & Analysis

  • West Virginia vs Clemson: Total Pick for Friday Night article feature image

    West Virginia vs Clemson: Total Pick for Friday Night

    John Feltman•
    Nov 21, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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West Virginia vs. Clemson Public Betting Percentages

Away Logo

West Virginia

Public

Home Logo

Clemson

63%

Bets%

37%

Money%

NCAAB Public Betting Right Arrow

Betting Trends

  • Clemson are 1-4 in their last 5 games.
  • Clemson are 2-3 in their last 5 games against the spread
  • Clemson are 9-3 in their road games against the spread
  • The totals have gone OVER in 2 of Clemson' last 5 games
  • The totals have gone OVER in 5 of Clemson' 16 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Clemson		16-127-99-313-123-0
West Virginia		13-148-95-56-86-5

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Clemson		11-175-116-610-151-2
West Virginia		8-194-134-63-114-7

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Clemson		20-8N/AN/A20-50-3
West Virginia		16-11N/AN/A10-44-7

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 18thUNAW 81-61-25.5 LU 144.5CLEM -9000
Nov 15th@GTWNL 74-79-1.5 LO 142.5GTWN -117
Nov 12thMOREW 83-56-29.5 LU 151.5CLEM -6500
Nov 8thWEBBW 97-59---
Nov 4thUNHW 88-38-29.5 WU 146.5CLEM -20000

West Virginia vs. Clemson Injury Updates

West Virginia Injuries

    Clemson Injuries

    • Zac Foster
      G

      Foster is out for season with knee

      Out for Season

    • Trent Steinour
      F/C

      Steinour is questionable with undisclosed

      Questionable

    See more NCAAB Injuries Right Arrow
    Team Stats

    23-57 (40%)
    Field Goals
    24-52 (46%)
    12-19 (63%)
    Free Throws
    15-19 (79%)
    9-23 (39%)
    3P
    7-22 (32%)
    29
    Rebounds
    32
    9
    Assists
    12
    7
    Turnovers
    11
    8
    Steals
    5
    3
    Blocks
    4
    17
    Fouls
    15

    West Virginia vs. Clemson Odds Comparison

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    West Virginia at Clemson Team Totals

    MatchupOverUnder
    West Virginia
    16-11
    N/A
    N/A
    Clemson
    20-8
    N/A
    N/A