Eastern Conference postseason action continues tonight, Tuesday, April 21, as the Boston Celtics (1-0) look to defend home court once more against the Philadelphia 76ers (0-1). This Game 2 showdown is slated for 7:00 p.m. ET at TD Garden in Boston, with live coverage available exclusively on Peacock.
Boston is a 14-point favorite on the spread in Game 2 tonight (Celtics -14), with the game’s total currently positioned at 218 points. The Celtics are listed as -850 moneyline favorites to take a 2-0 lead, while the Sixers are priced as +575 underdogs to pull off the road upset and even the series.
Read on for my 76ers vs. Celtics predictions and NBA betting picks for tonight's playoff game.
- 76ers vs Celtics pick: Celtics -14 (-110)
My Celtics vs. 76ers best bet for Game 2 is on Boston to cover the spread. Make sure to find the best odds by checking our live NBA odds page.
Philadelphia 76ers vs Boston Celtics Odds
| 76ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+14 -110 | 218 -110o / -110u | +575 |
| Celtics Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-14 -110 | 218 -110o / -110u | -850 |
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Philadelphia 76ers vs Boston Celtics NBA Preview
The Sixers looked entirely unprepared for playoff basketball in the first game of this series. That could lead to a bounce-back performance — but, Philadelphia's problem was their lack of preparation and mental focus. I don’t know if they can turn that around in 48 hours.
I make the spread for this game Celtics -15 after some adjustments. My model originally made it within the number. So, I trust Boston, what could possibly go wrong?
The Celtics notoriously have a habit of screwing around and losing one game per series. It happens in almost every single series, and it's happened under multiple coaches.
The Sixers’ wings had a really bad shooting performance in Game 1. That should improve, but the confidence and execution that Boston had won’t be affected.
The depth of the Celtics is a huge factor.
Philadelphia is tossing out guys like Justin Edwards and Dominick Barlow — and the Celtics’ young guys are just much more polished.
It’s not all pointing in Boston’s direction, though. The Celtics are 1-3-1 ATS under Joe Mazzulla in Game 2 after winning and covering in Game 1.
76ers vs Celtics Picks, Betting Analysis
Celtics -14
We thought the Nuggets had control in their first round series against the Wolves; Denver lost. We thought the Knicks had complete control over the Hawks; New York lost. We thought the Cavaliers had complete control over the Raptors; and they did, in fact, and won Game 2 easily.
However, the Sixers are just not on the same level as those teams, as evidenced by their play-in status.
When Joel Embiid gets back, maybe there will be value on the Sixers — but until then, I’ll dare them to hang within the number against a Boston team that, for once, does not seem to be in a mood to screw around.
Quentin Grimes Over 4.5 Rebounds & Assists
Grimes has gone over this line in seven of his last 10 games — and I’m expecting more minutes from him because he’s got more seasoning and can handle the second unit.
Payton Pritchard Over 16.5 Points & Rebounds
Pritchard had a quiet Game 1, but rarely has back-to-back bad games. He's gone over this line in eight of his 10 outings.

76ers vs Celtics Game 2 Betting Predictions
- Celtics -14 (-110)
- Quentin Grimes Over 4.5 Rebounds & Assists (-130)
- Payton Pritchard Over 16.5 Points & Rebounds (-120)
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76ers vs Celtics Betting Trends


















