With a full, 15-game slate on the calendar for Tuesday, May 13, baseball fans have no shortage of viewing options.
That also means there are numerous betting options, which is where we come in. Our MLB betting experts and systems have analyzed all the odds and identified the best MLB picks and props today. So, continue reading as our MLB best bets are below.
MLB Best Bets Today
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 6:10 p.m. | |
  | 7:07 p.m. | |
  | 8:10 p.m. | |
  | 10:10 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Bet Labs' Brewers vs Guardians Best Bet: Back the Road 'Dog
By Bet Labs
In interleague matchups early in a series, road underdogs often hold unseen advantages. These games introduce travel and scouting uncertainty, and early games feature lineups and matchups unfamiliar to bettors and models.
Public perception tends to lean too heavily on home-field advantage, but interleague games introduce more unpredictability due to differences in lineup construction and unfamiliar opposing pitchers. When combined with road 'dog pricing, it creates exploitable inefficiencies in early matchups. This system has a 4.7% ROI since 2017.
Pick: Brewers Moneyline (+108)
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Grant Neiffer's Rays vs Blue Jays Best Bet: Great Value on Lowe
This ballpark is a bit of a downgrade for Brandon Lowe, but not any more of a downgrade than Tampa’s ballpark last season. The matchup is above average vs. Jose Berrios, who has struggled with lefty power in his career, giving up a high 1.45 HR/9 to go along with heavy fly-ball and hard-contact numbers.
Lowe is an above-average power hitter and is generally on a 30-homer pace per 162 games. I have the true odds here around +500, making this a great bet.
Pick: Brandon Lowe Over 0.5 Home Runs (+625)
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Charlie Wright's Royals vs Astros Best Bet: Both Starters Throwing Well
Kris Bubic tossed seven scoreless innings against Colorado last time out and is yet to give up a run this month. The dominant outing trimmed Bubic's ERA to 1.69, which is the fourth-best mark among qualified pitchers. Bubic's ERA estimators are all in the mid-3.00s, so he appears to be legit.
His only underwhelming start (5 IP, 4 ERs) this season came against these Astros, but that comes with a big caveat. Yordan Alvarez (three-run homer) did the majority of the damage against Bubic in that outing, but is now on the IL. The Astros should send a bunch of righties to the plate, which is a plus for Bubic, who has reverse splits.
Framber Valdez has had a few stinkers this season, but he's coming off seven innings of one-run ball against Milwaukee. His sinker/curveball combo still looks elite and he's getting tons of ground balls. The changeup has been knocked around, and we've seen him go to the slider a bit more often recently. The slider grades out well, so it should be a solid option if the changeup isn't viable.
The bigger key for Valdez is the matchup. Houston ranks decently well against lefties, but Kansas City has struggled. The Royals rank 26th in OPS and 25th in wOBA and wRC+. The lineup they rolled out against Garrett Crochet on Saturday had just a .072 ISO and a .301 wOBA across 236 plate appearances vs. left-handed pitching in 2025. Valdez cruised through eight innings with two earned runs against this squad in late April.
Pick: First 5 Innings Under 4.5 (-135)
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Bet Labs' Athletics vs Dodgers Best Bet: Fade the Powerhouse Dodgers
By Bet Labs
