If you're looking for the MLB best bets for Wednesday, you've come to the right place.
Our betting experts have put together their four best MLB picks and predictions for Wednesday, so be sure to continue reading for their insight and analysis.
MLB Best Bets, Picks & Predictions for Wednesday
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from the Wednesday slate of games. Click on the team logos for any of the matchups below to navigate to a specific MLB best bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 6:45 p.m. | |
  | 7:45 p.m. | |
  | 1:10 p.m. | |
| 1:10 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
William Boor's Diamondbacks vs. Guardians Best Bet: Grab Arizona's Moneyline
By William Boor
If it ain't broke, don't fix it.
The Arizona Diamondbacks have won seven of their past nine games and will look to keep that streak going today.
While I typically focus on the pitching matchup in these breakdowns, it's impossible to ignore what Arizona's offense has been doing. In 16 games since the All-Star break, the Diamondbacks have scored five or more runs 11 — yes, 11 — times.
Arizona has played itself into a NL wild-card spot and will certainly be a tough matchup for Cleveland's Ben Lively, who has pitched to a 3.42 ERA and a 3.64 xERA this season.
Lively has thrown well of late, but also ranks in the 20th percentile or lower in hard-hit rate, whiff percentage, chase rate, fastball velocity and average exit velocity.
The Diamondbacks will counter with Brandon Pfaadt, who has allowed one earned run or fewer in four of his past six starts. Pfaadt has pitched to a 3.98 ERA with a 3.31 xERA over 131 1/3 innings (22 starts) this season.
The 25-year-old's advanced metrics don't jump off the page and he's roughly in the middle of the pack in most categories, but he's been throwing well lately and Arizona's offense is on fire.
With Pfaadt throwing well and the D'backs seemingly scoring at will, I'm more than happy to bet on Arizona to pick up a road win.
Pick: Diamondbacks Moneyline (-126)
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Tony Sartori's Diamondbacks vs. Guardians Best Bet: Back Arizona Early
By Tony Sartori
Arizona possesses every advantage in this matchup, at least in the F5 market. Brandon Pfaadt outranks Ben Lively in WHIP, xERA, average exit velocity, strikeout rate, walk rate and barrel rate.
Meanwhile, the D'backs pace the Guardians in runs scored per game, hits per game, BA, OBP, SLG, OPS and home runs. The reason why I'd rather attack the F5 than the full game is that Cleveland boasts the best bullpen in baseball, and I want to avoid a late comeback.
Furthermore, Pfaadt boasts a commanding 2.86 ERA over his past five starts. Arizona's F5 record is 4-0-1 over that stretch.
Pick: Diamondbacks F5 Moneyline (-135)
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D.J. James' Nationals vs. Giants Best Bet: Underdog Nats Have Value
By D.J. James
Blake Snell is coming off of a no-hitter, and teams are surely kicking themselves for not going after the savvy lefty earlier in free agency. Snell has limited hard contact and maintains a strong argument for being one of the most underrated arms in the game. However, he struggles with consistently throwing strikes and doesn't keep the ball on the ground.
His opponent will be Jake Irvin, who isn't flashy, but holds a sub-4.00 xERA. Irvin also ranks in the 59th percentile in ground-ball rate and is only walking 5.9% of hitters. After throwing deep (obviously) in his most recent start, Snell could experience some fatigue that Irvin simply may not have.
Adding on, the Washington Nationals have crushed lefties in the past month with a 112 wRC+, a 6.8% walk rate and a 16.5% strikeout rate. Basically, they can make contact and infuriate Snell on the mound. The Nationals should limit strikeouts and eliminate a key feature of Snell’s game.
The Giants are about league average against righties in the past month. Heliot Ramos has been dealing with a thumb injury, but is back in the lineup.
Now, the Giants have the better bullpen, but seeing how Snell responds after a complete game could throw a wrench in their plans.
With these issues potentially coming about, the Nats actually hold value with a solid starter at the helm. Take them from +140 to +115.
Pick: Nationals Moneyline (+140)
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PRO Systems' Rays vs. Cardinals Best Bet: Target The Over/Under
Weather has been a pain in the you-know-what this week and Bet Labs rolled out another trio of games being affected Wednesday.
One of those is Rays vs. Cardinals. The wind won't be all that daunting (it's not forecasted to reach double digits), but the parameters for Wednesday's clash meet the criteria for a PRO Systems pick on the under.
Be sure to check out PRO Systems other picks fitting this model, including a game featuring 12 mph winds blowing directly in.
Pick: Under 7.5 (-110)
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