The Arizona Diamondbacks host the Chicago White Sox on April 22, 2026. First pitch from Chase Field is scheduled for 9:40 p.m. EDT. The game will be broadcast on ARID.
The Diamondbacks are favored by -152 on the moneyline and by -1.5 on the run line. The White Sox are +128 on the moneyline and +1.5 on the run line. The total is set at 9 runs.
Find my MLB picks and White Sox vs Diamondbacks prediction below, as well as probable pitchers, weather report, and more.
White Sox vs Diamondbacks Prediction
- White Sox vs Diamondbacks Pick: Under 9
My White Sox vs Diamondbacks best bet is on the Under. Make sure to find the best odds by checking our live MLB odds page.
White Sox vs Diamondbacks Odds
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -156 | 9 -122o / -100u | +128 |
| Diamondbacks Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +130 | 9 -122o / -100u | -152 |
- White Sox vs Diamondbacks moneyline: White Sox +128, Diamondbacks -152
- White Sox vs Diamondbacks over/under: 9 (-122o / -100u)
- White Sox vs Diamondbacks spread: Diamondbacks -1.5 (+130), White Sox +1.5 (-156)
White Sox vs Diamondbacks Kalshi Odds
White Sox vs Diamondbacks Pitchers
| Anthony Kay (LHP, CWS) | Stat | Eduardo Rodriguez (LHP, ARI) |
|---|---|---|
| 1-0 | W-L | 1-0 |
| 0.0 | fWAR (FanGraphs) | 0.2 |
| 2.60 / 6.88 | ERA / xERA | 1.96 / 4.17 |
| 5.33 / 5.34 | FIP / xFIP | 4.23 / 4.65 |
| 3.8% | K-BB% | 5.2% |
| 38.9% | GB% | 42.5% |
| .212 | BABIP | .239 |
| 102 | Stuff+ | 89 |
| 98 | Location+ | 102 |
White Sox vs Diamondbacks MLB Betting Preview
Our own Sean Zerillo projects an edge on the total for this matchup
While the consensus line sits at 9, Zerillo projects around 8.6 runs for this game, representing a 3.3% edge against the market.
As a reminder, you can see all of Zerillo's MLB game projections with an Action PRO Subscription. Find his projected lines every day on the PRO Projections tab.
Pick: Under 9
