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A’s vs Yankees Predictions, Odds, Picks

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Sep 21, 2025; Pittsburgh, Pennsylvania, USA; Athletics designated hitter Brent Rooker (25) hits a single against the Pittsburgh Pirates during the first inning at PNC Park. Mandatory Credit: Charles LeClaire-Imagn Images

The Yankees (8-2) host the Athletics (3-7) tonight for the second game of their series. First pitch from Yankee Stadium is scheduled for 7:05 p.m. ET. A's vs Yankees will broadcast on Amazon Prime Video.

The Yankees are -205 favorites on the moneyline and by -1.5 on the run line (-102). The A's are +172 underdogs on the moneyline and +1.5 on the run line (-118). The total is set at 8.5 (-102o / -120u).

Find my A's vs Yankees prediction below, as well as the latest MLB odds, probable pitchers, viewing information and more.


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A's vs Yankees Predictions, Picks

  • Athletics vs Yankees Pick: Over 8.5 (-112 or Better)

My Athletics vs Yankees best bet is on the Over. Make sure to find the best odds by checking our live MLB odds page.


A's vs Yankees Odds, Lines

Athletics Logo
Wednesday, April 8
7:05 p.m. ET
Prime Video
Yankees Logo
Athletics Odds
SpreadOver/UnderMoneyline
+1.5
-118
8.5
-102o / -120u
+172
Yankees Odds
SpreadOver/UnderMoneyline
-1.5
-102
8.5
-102o / -120u
-205
Odds via FanDuel. Get up-to-the-minute MLB odds here.
FanDuel Logo
  • Athletics vs Yankees spread: Yankees -1.5 (-102), Athletics +1.5 (-118)
  • Athletics vs Yankees over/under: 8.5 (-102o / -120u)
  • Athletics vs Yankees moneyline: Athletics +172, Yankees -205


A's vs Yankees Projected Starting Pitchers

Luis Severino (RHP)StatWill Warren (RHP)
0-1W-L1-0
0.1fWAR (FanGraphs)0.0
6.48 / 4.51ERA / xERA2.70 / 2.83
3.63 / 4.60FIP / xFIP4.55 / 3.43
1.80WHIP1.10
5.3%K-BB%17.5%
40.0%GB%55.2%
106Stuff+110
80Location+112

A's vs Yankees Preview, Prediction

Our own Sean Zerillo projects a decent edge on the Over in this matchup.

While the consensus line sits around 8.5 with low juice toward the Over, Zerillo projects nearly 9.1 runs for the game, representing a nearly 3% edge against the market.

As a reminder, you can see all of Zerillo's MLB game projections with an Action PRO Subscription. Find his projected lines every day on the PRO Projections tab.  

As written in his Opening Pitch column, Zerillo says he would bet the Over 8.5 at -112 or better.

Zerillo's MLB Bets for Wednesday Image

Pick: Over 8.5 (-112 or Better)

Playbook

A's vs Yankees Betting Trends


A's vs Yankees Viewing Info: Channel, Start Time, Streaming

Location:Yankee Stadium
Date:Wednesday, April 8
Time:7:05 p.m. ET
TV / Streaming Options:Amazon Prime Video

A's vs Yankees Weather


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Author Profile
About the Author

Tanner McGrath covers college basketball, college football and Major League Baseball at Action Network. He is a contributor to Payoff Pitch, Action Network’s Major League Baseball betting podcast. He's been working in the space for more than five years with past journalism experience in Canadian collegiate sports, finance and economics. He has an obsession with America East basketball, betting the Miami Marlins and sweating out home underdogs.

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