White Sox vs. Guardians Odds & Betting Predictions - September 13, 2025

White Sox at Guardians

10:10 pm • CHSN

Chicago White Sox

1

1 - 2

Cleveland Guardians

2

MatchupOpenSpreadTotalMoneyline
White Sox 57-91	+1.5	+1.5-150	o7.5-115	+146
Guardians 76-71	u8	-1.5+126	u7.5-105	-171

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Saturday 10:10 p.m.

September 13, 2025

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Action Network Staff•
Sep 13, 2025 UTC

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MLB Public Betting

Guardians are 4-1 in their last 5 games.
Guardians are 4-1 in their last 5 games against the spread
Guardians are 41-33 in their road games against the spread
The totals have gone OVER in 1 of Guardians' last 5 games
The totals have gone OVER in 34 of Guardians' 73 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	77-70	36-37	41-33	30-30	46-38
White Sox	87-61	44-31	43-30	0-2	86-59

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	64-77-6	34-36-3	30-41-3	31-28-1	32-47-5
White Sox	70-71-7	40-30-5	30-41-2	0-2	69-69-7

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	76-71	39-34	37-37	38-22	38-46
White Sox	57-91	32-43	25-48	1-1	55-90

date	opponent	score	spread	over/under	moneyline
Sep 12th	CWS	W 4-0	-1.5 W	U 7.5	CLE -142
Sep 11th	KC	W 3-2	-	-	CLE -144
Sep 10th	KC	L 3-4	+1.5 W	U 8	KC -110
Sep 9th	KC	W 2-0	+1.5 W	U 7.5	CLE -110
Sep 8th	KC	W 10-2	+1.5 W	O 7.5	CLE -115

Ben Lively
SP
Lively is out with elbow
Out
John Means
SP
Means is out with elbow
Out

Ky Bush
SP
Bush is out with elbow
Out
Drew Thorpe
SP
Thorpe is out with elbow
Out

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PITCHER		PC	IP	K	ER
RD.Martin, P		85	5	3	2
LT.Gilbert, P		11	0.2	1	0

HITTERS	H-AB	R	HR	RBI
1C.Meidroth, SS	1-3	1	0	0
2C.Mead, 1B	1-3	0	0	0
3E.Quero, C	2-3	0	0	0
4L.Sosa, 2B	1-3	0	0	1
5M.Tauchman, RF	0-3	0	0	0
6M.Vargas, 3B	0-3	0	0	0
7A.Benintendi, DH	0-2	0	0	0
8M.Taylor, CF	1-1	0	0	0
9W.Robertson, LF	1-2	0	0	0

PITCHER		PC	IP	K	ER
LP.Messick, P		93	6	4	1

HITTERS	H-AB	R	HR	RBI
1S.Kwan, DH	1-3	0	0	0
2D.Schneemann, CF	0-3	0	0	0
3J.Ramirez, 3B	0-3	0	0	0
4K.Manzardo, 1B	1-3	0	0	0
5N.Jones, LF	0-2	0	0	0
6G.Arias, SS	1-2	0	0	0
7B.Naylor, C	1-2	1	0	0
8C.Kayfus, RF	1-2	1	1	2
9B.Rocchio, 2B	0-2	0	0	0

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MatchupOverUnder
White Sox 57-91	N/A	N/A
Guardians 76-71	N/A	N/A