Twins vs. Red Sox Odds & Betting Predictions - May 22, 2026

Twins at Red Sox

11:10 pm • NESN
8 - 6
Starting Pitchers
pitcherteameraw-l
Payton Tolle logoP.TolleBoston Red Sox logo2.462-2
Connor Prielipp logoC.PrielippMinnesota Twins logo4.031-2

Twins at Red Sox Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Twins
24-27
+1.5
+1.5-172
o7.5-107
+127
Red Sox
22-28
u7.5
-1.5+144
u7.5-113
-153
location pinFriday 11:10 p.m.
May 22, 2026
Fenway ParkBoston
Twins vs. Red Sox Expert Picks
The Degenerates
The Degenerates
Last 30d: 84-91-9 (-10.7u)
Under 8-128
1.28u
Austin Pendergrass
Austin Pendergrass
Last 30d: 34-23-0 (+2.2u)
Under 8.5-154
0.5u
Payoff Pitch Podcast
Payoff Pitch Podcast
Last 30d: 81-103-10 (+6.1u)
Under 7.5-105
0.5u
@Zerillo ⭐️⭐️ https://myaction.app/mcSZfWMQl3b
Frank Ammirante
Frank Ammirante
Last 30d: 244-267-10 (-12.3u)
P.Tolle o15.5 Outs-115
1u
Under 7.5-105
1.05u
Adam Kaufman
Adam Kaufman
Last 30d: 36-44-0 (-13.6u)
BOS -148
1.48u
Sean Zerillo
Sean Zerillo
Last 30d: 173-148-12 (+3.0u)
Under 8-118
0.59u
Bet to 7.5 (-105)

Twins vs. Red Sox Previews & Analysis

  • Adam Trigger's Triple-A Baseball Picks for Friday article feature image

    Adam Trigger's Triple-A Baseball Picks for Friday

    Adam Trigger
    May 22, 2026 UTC
  • Twins vs Red Sox: Zerillo's Over/Under Pick for Friday article feature image

    Twins vs Red Sox: Zerillo's Over/Under Pick for Friday

    Sean Zerillo
    May 22, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Twins vs. Red Sox Public Betting Percentages

Away Logo

Twins

Public

22%

Bets%

78%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Red Sox
19-317-1612-1512-206-11
Twins
27-2417-1210-127-720-16

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Red Sox
22-27-16-16-116-1114-17-18-9
Twins
28-19-414-11-414-87-6-120-13-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Red Sox
22-288-1514-1315-176-11
Twins
24-2715-149-136-818-18

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 20th@KCW 4-3-1.5 LU 7.5BOS +100
May 19th@KCW 7-1-1.5 WO 7.5BOS -138
May 18th@KCW 3-1-1.5 WU 9BOS -113
May 17th@ATLL 1-8+1.5 LO 8.5ATL +122
May 16th@ATLW 3-2-1.5 LU 7.5BOS +100

Red Sox vs. Twins Injury Updates

Red Sox Injuries

  • Tanner Houck
    SP

    Houck is out with arm

    Out

  • Triston Casas
    1B

    Casas is out with knee

    Out

  • Patrick Sandoval
    SP

    Sandoval is out with elbow

    Out

  • Kutter Crawford
    SP

    Crawford is out with wrist

    Out

  • Romy Gonzalez
    1B

    Gonzalez is out with shoulder

    Out

Twins Injuries

  • Pablo Lopez
    SP

    Lopez is out with elbow

    Out

  • David Festa
    SP

    Festa is out with shoulder

    Out

  • Travis Adams
    SP

    Adams is out with triceps

    Out

Twins vs. Red Sox Box Score
Twins Player Stats
Projected
PITCHERPCIPKER
Connor Prielipp logoLC.Prielipp, P85415
Travis Adams logoRT.Adams, P29230
Yoendrys Gomez logoRY.Gomez, P13110
Eric Orze logoRE.Orze, P140.210
Anthony Banda logoLA.Banda, P141.110
HITTERSH-ABRHRRBI
Byron Buxton logo1B.Buxton, DH2-5113
Brooks Lee logo2B.Lee, 3B0-4200
Austin Martin logo3A.Martin, CF2-5112
Austin Martin logo3A.Martin, RF2-5112
Josh Bell logo4J.Bell, 1B1-4100
James Outman logo4J.Outman, CF0-0000
Gabriel Gonzalez logo5G.Gonzalez, LF1-2100
Trevor Larnach logo5T.Larnach, PH0-0001
Trevor Larnach logo5T.Larnach, LF0-0001
Ryan Kreidler logo6R.Kreidler, SS2-5101
Kody Clemens logo7K.Clemens, RF0-5000
Kody Clemens logo7K.Clemens, 1B0-5000
Luke Keaschall logo8L.Keaschall, 2B2-4101
Alex Jackson logo9A.Jackson, C0-4000
Red Sox Player Stats
Projected
PITCHERPCIPKER
Payton Tolle logoLP.Tolle, P85693
Justin Slaten logoRJ.Slaten, P280.214
Greg Weissert logoRG.Weissert, P231.100
Tyler Samaniego logoLT.Samaniego, P6000
Tayron Guerrero logoRT.Guerrero, P16110
HITTERSH-ABRHRRBI
Jarren Duran logo1J.Duran, LF0-4101
Ceddanne Rafaela logo2C.Rafaela, CF0-4000
Wilyer Abreu logo3W.Abreu, RF2-5101
Willson Contreras logo4W.Contreras, 1B1-4101
Andruw Monasterio logo5A.Monasterio, DH1-2101
Masataka Yoshida logo5M.Yoshida, PH0-1000
Masataka Yoshida logo5M.Yoshida, DH0-1000
Nick Sogard logo6N.Sogard, SS2-3100
Nick Sogard logo6N.Sogard, 3B2-3100
Marcelo Mayer logo7M.Mayer, 2B0-3001
Carlos Narvaez logo8C.Narvaez, C1-3100
Caleb Durbin logo9C.Durbin, 3B0-2001
Mickey Gasper logo9M.Gasper, PH0-1000
Isiah Kiner-Falefa logo9I.Kiner-Falefa, SS0-0000

Twins vs. Red Sox Odds Comparison

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Twins at Red Sox Team Totals

MatchupOverUnder
Twins
24-27
N/A
N/A
Red Sox
22-28
N/A
N/A