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Reds vs. Cardinals Odds & Betting Predictions - September 15, 2025

Reds at Cardinals

11:45 pm • FDSMW
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Cincinnati Reds

74-74
@

St. Louis Cardinals

72-77
Starting Pitchers
pitcherteameraw-l
Matthew Liberatore logoM.LiberatoreSt. Louis Cardinals logo4.357-12
Zack Littell logoZ.LittellCincinnati Reds logo3.588-8

Reds at Cardinals Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Reds
74-74
-1.5
+1.5-200
o8.5-109
+105
Cardinals
72-77
u8
-1.5+162
u8.5-112
-125
location pinMonday 11:45 p.m.
September 15, 2025
Busch StadiumSt. Louis
thermometer image84°Fahrenheit
rain image0%Rain
wind image5Wind
Reds vs. Cardinals Expert Picks
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 133-155-2 (-30.7u)
STL -124
1u
Moneyline Hacks
Moneyline Hacks
Last 30d: 107-118-6 (+37.2u)
Under 8.5-110
1u
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Prop Odds Comparison

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No props found

Line Movement Tracker

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Reds vs. Cardinals Public Betting Percentages

Away Logo

Reds

Public

Home Logo

Cardinals

41%

Bets%

59%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Cardinals are 0-5 in their last 5 games.
  • Cardinals are 1-4 in their last 5 games against the spread
  • Cardinals are 36-38 in their road games against the spread
  • The totals have gone OVER in 3 of Cardinals' last 5 games
  • The totals have gone OVER in 37 of Cardinals' 75 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cardinals		73-7637-3836-3825-4047-36
Reds		76-7038-3438-3627-3649-33

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cardinals		75-67-737-35-338-32-432-28-542-39-2
Reds		54-83-925-41-629-42-319-41-334-42-6

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cardinals		72-7741-3431-4333-3238-45
Reds		74-7439-3334-4034-2939-43

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 14th@MILW 3-2+1.5 WU 8.5STL +160
Sep 14th@MILL 8-9+1.5 WO 8MIL +154
Sep 13th@MILL 2-8+1.5 LO 8.5MIL +158
Sep 11th@SEAL 2-4+1.5 LU 7.5SEA +177
Sep 10th@SEAL 3-5+1.5 LO 7.5SEA +160

Cardinals vs. Reds Injury Updates

Cardinals Injuries

  • Nolan Arenado
    3B

    Arenado is out with shoulder

    Out

  • Masyn Winn
    SS

    Masyn Winn (knee) has been scratched Friday.

    Out

Reds Injuries

  • Noelvi Marte
    3B

    Marte is day-to-day with side

    Day-to-Day

  • Reiver Sanmartin
    RP

    Sanmartin is out with elbow

    Out

  • Brandon Williamson
    SP

    Williamson is out for season with elbow

    Out for Season

  • Graham Ashcraft
    RP

    Ashcraft is out with groin

    Out

  • Chase Burns
    SP

    Burns is out with hip

    Out

  • Julian Aguiar
    SP

    Aguiar is out for season with elbow

    Out for Season

  • Rhett Lowder
    SP

    Lowder is out with elbow

    Out

  • Carson Spiers
    RP

    Spiers is out with shoulder

    Out

See more MLB Injuries Right Arrow
Reds vs. Cardinals Starting Lineups
Reds Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Zack Littell logoRZ.Littell, P8-83.581.1176.01
HITTERSAVGOBPSLGHR
TJ Friedl logo1T.Friedl, CF.263.366.37612
Noelvi Marte logo2N.Marte, RF.273.314.47212
Elly De La Cruz logo3E.De La Cruz, SS.265.333.43619
Miguel Andujar logo4M.Andujar, DH.298.329.4366
Austin Hays logo5A.Hays, LF.265.316.46115
Spencer Steer logo6S.Steer, 1B.237.308.39617
Tyler Stephenson logo7T.Stephenson, C.223.309.40311
Ke'Bryan Hayes logo8K.Hayes, 3B.274.350.4113
Matt McLain logo9M.McLain, 2B.226.307.35114
Cardinals Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Matthew Liberatore logoLM.Liberatore, P7-124.351.3297.04
HITTERSAVGOBPSLGHR
Brendan Donovan logo1B.Donovan, 2B.279.348.40610
Ivan Herrera logo2I.Herrera, DH.285.373.46516
Alec Burleson logo3A.Burleson, LF.283.333.45317
Willson Contreras logo4W.Contreras, 1B.255.342.44420
Lars Nootbaar logo5L.Nootbaar, CF.242.326.37713
Thomas Saggese logo6T.Saggese, SS.259.300.3351
Nolan Gorman logo7N.Gorman, 3B.211.306.38414
Jordan Walker logo8J.Walker, RF.218.271.3085
Jimmy Crooks logo9J.Crooks, C.100.143.2501

Reds vs. Cardinals Odds Comparison

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Reds at Cardinals Team Totals

MatchupOverUnder
Reds
74-74
N/A
N/A
Cardinals
72-77
N/A
N/A