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Giants vs. Cardinals Odds & Betting Predictions - September 6, 2025

Giants at Cardinals

12:15 am • FDSMW
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San Francisco Giants

71-69
@

St. Louis Cardinals

70-71
Starting Pitchers
pitcherteameraw-l
Michael McGreevy logoM.McGreevySt. Louis Cardinals logo4.176-2
Carson Seymour logoC.SeymourSan Francisco Giants logo4.740-2

Giants at Cardinals Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Giants
71-69
-1.5
-1.5+161
o8.5-105
+100
Cardinals
70-71
u7.5
+1.5-196
u8.5-117
-120
location pinSaturday 12:15 a.m.
September 06, 2025
Busch StadiumSt. Louis
thermometer image69°Fahrenheit
rain image0%Rain
wind image6Wind
Giants vs. Cardinals Expert Picks
Picks Office
Picks Office
Last 30d: 75-69-4 (+4.0u)
Over 8-115
1u
Payoff Pitch Podcast
Payoff Pitch Podcast
Last 30d: 32-37-1 (+2.9u)
STL -115
1u
@Zerillo https://myaction.app/yZfLli0ZpWb
Moneyline Hacks
Moneyline Hacks
Last 30d: 88-80-5 (+21.0u)
C.Seymour u3.5 Ks+100
1u
🚨Free analysis & VIP Picks can be found on our Discord. Link: https://discord.gg/A8v49URQaG 🎙️Fade the Noise PODCAST - Subscribe!✅ https://www.youtube.com/@FadetheNoise Link to VIP (Copy &Paste): https://linktr.ee/moneylinehacks%F0%9F%94%A560% OFF with promo code: Hacks60
Sean Zerillo
Sean Zerillo
Last 30d: 178-175-4 (+6.7u)
STL -108
0.54u
Bet to -115
Under 8.5-115
0.58u
Bet to 8 (-105)

Prop Odds Comparison

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No props found

Line Movement Tracker

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Giants vs. Cardinals Public Betting Percentages

Away Logo

Giants

Public

Home Logo

Cardinals

49%

Bets%

51%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Cardinals are 3-2 in their last 5 games.
  • Cardinals are 3-2 in their last 5 games against the spread
  • Cardinals are 35-34 in their road games against the spread
  • The totals have gone OVER in 2 of Cardinals' last 5 games
  • The totals have gone OVER in 36 of Cardinals' 72 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cardinals		71-7036-3635-3425-3845-32
Giants		64-7629-4035-3631-5132-24

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cardinals		71-63-736-33-335-30-431-27-539-36-2
Giants		65-70-528-40-137-30-430-51-133-19-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cardinals		70-7139-3331-3832-3137-40
Giants		71-6935-3436-3544-3826-30

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 3rdATHW 5-1+1.5 WU 8.5STL -111
Sep 2ndATHW 2-1+1.5 WU 8.5STL -108
Sep 1stATHL 3-11-1.5 LO 7.5ATH -158
Aug 31st@CINL 4-7+1.5 LO 8.5CIN +116
Aug 30th@CINW 4-2+1.5 WU 8STL +123

Cardinals vs. Giants Injury Updates

Cardinals Injuries

  • Nolan Arenado
    3B

    Arenado is out with shoulder

    Out

  • Brendan Donovan
    2B

    Donovan is out with groin

    Out

Giants Injuries

  • Tom Murphy
    C

    Murphy is out with back

    Out

  • JT Brubaker
    RP

    Brubaker is out with ribs

    Out

See more MLB Injuries Right Arrow
Giants vs. Cardinals Starting Lineups
Giants Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Carson Seymour logoRC.Seymour, P0-24.741.5006.57
HITTERSAVGOBPSLGHR
Heliot Ramos logo1H.Ramos, LF.268.341.40516
Rafael Devers logo2R.Devers, DH.272.401.50415
Willy Adames logo3W.Adames, SS.230.317.42626
Dominic Smith logo4D.Smith, 1B.284.338.4044
Matt Chapman logo5M.Chapman, 3B.234.345.44720
Jung Hoo Lee logo6J.Lee, CF.262.326.4067
Casey Schmitt logo7C.Schmitt, 2B.238.312.40510
Drew Gilbert logo8D.Gilbert, RF.260.275.5403
Patrick Bailey logo9P.Bailey, C.213.272.3003
Cardinals Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Michael McGreevy logoRM.McGreevy, P6-24.171.1885.22
HITTERSAVGOBPSLGHR
Lars Nootbaar logo1L.Nootbaar, LF.243.332.38713
Ivan Herrera logo2I.Herrera, DH.284.367.44513
Nolan Gorman logo3N.Gorman, 1B.220.317.40914
Masyn Winn logo4M.Winn, SS.255.311.3679
Jimmy Crooks logo5J.Crooks, C.143.143.5711
Thomas Saggese logo6T.Saggese, 3B.249.290.3261
Jordan Walker logo7J.Walker, RF.218.272.3095
Victor Scott logo8V.Scott, CF.223.311.3115
Jose Fermin logo9J.Fermin, 2B.310.375.4831

Giants vs. Cardinals Odds Comparison

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Giants at Cardinals Team Totals

MatchupOverUnder
Giants
71-69
N/A
N/A
Cardinals
70-71
N/A
N/A