Brewers vs. Cardinals Odds & Betting Predictions - September 21, 2025

Brewers at Cardinals

6:15 pm • FDSMW

Milwaukee Brewers

45-28

1 - 5

St. Louis Cardinals

40-34

pitcher		team	era	w-l
M.Liberatore			4.21	8-12
R.Gasser			3.18	0-2

MatchupOpenSpreadTotalMoneyline
Brewers 45-28	-1.5	-1.5+125	o8.5-110	-132
Cardinals 40-34	u9	+1.5-150	u8.5-110	+113

Sunday 6:15 p.m.

September 21, 2025

Busch StadiumSt. Louis

Under 8.5-105

0.5u

Could see this as a potential rest spot for some Milwaukee bats with their magic number down to 1 to clinch division. Cardinals already sitting Arenado/Donovan/Pozo and starting five LHB vs the lefty Gasser, so it sets up well for Gasser. Can wait for MIL lineup as they still need to win this game to clinch and Cardinals aren’t playing for anything, but like how this matches up for Gasser and think Liberatore could be in a good spot too if Brewers rest someone like Contreras (who has played five straight games)

No props found

MLB Public Betting

Cardinals are 2-3 in their last 5 games.
Cardinals are 1-4 in their last 5 games against the spread
Cardinals are 22-14 in their road games against the spread
The totals have gone OVER in 2 of Cardinals' last 5 games
The totals have gone OVER in 17 of Cardinals' 38 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cardinals	44-30	22-16	22-14	9-7	35-22
Brewers	41-32	23-17	18-15	28-23	13-9

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cardinals	32-38-4	17-19-2	15-19-2	6-9-1	25-29-3
Brewers	33-39-1	18-22	15-17-1	25-25-1	8-14

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cardinals	40-34	21-17	19-17	11-5	29-28
Brewers	45-28	25-15	20-13	33-18	12-10

date	opponent	score	spread	over/under	moneyline
Sep 20th	MIL	L 2-3	+1.5 W	U 8.5	MIL +121
Sep 20th	MIL	W 7-1	+1.5 W	O 7.5	-
Sep 17th	CIN	L 2-6	+1.5 L	U 8.5	CIN +102
Sep 16th	CIN	W 3-0	+1.5 W	U 8	STL +105
Sep 15th	CIN	L 6-11	+1.5 L	O 8.5	CIN -113

Akil Baddoo
LF
Baddoo is out with quad
Out
Quinn Priester
SP
Priester is out with wrist
Out
Drew Rom
SP
Rom is out with biceps
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
LR.Gasser, P	45	3	2	2
RE.Fedde, P	56	4	1	3
LR.Zastryzny, P	5	0.2	1	0
RG.Anderson, P	14	0.1	0	0

HITTERS	H-AB	R	RBI
1J.Chourio, RF	0-4	0	1
2I.Collins, LF	0-3	0	0
3A.Vaughn, 1B	0-4	0	0
4R.Hoskins, DH	0-3	0	0
4C.Yelich, PH	0-1	0	0
4C.Yelich, DH	0-1	0	0
5C.Durbin, 3B	0-2	0	0
6A.Monasterio, 2B	3-4	0	0
7D.Jansen, C	0-4	0	0
8B.Perkins, CF	2-3	0	0
8B.Turang, PH	0-1	0	0
9J.Ortiz, SS	2-3	1	0
9J.Bauers, PH	0-0	0	0

PITCHER	PC	IP	K	ER
LM.Liberatore, P	85	5	6	1
RM.Svanson, P	35	2	2	0
RR.Fernandez, P	16	1	2	0
RR.O'Brien, P	15	1	0	0

HITTERS	H-AB	R	HR	RBI
1T.Saggese, SS	0-4	0	0	0
2I.Herrera, DH	1-2	2	1	2
3A.Burleson, 1B	1-3	0	0	0
4L.Nootbaar, LF	0-3	0	0	0
4N.Church, LF	0-0	0	0	0
5J.Walker, RF	0-2	1	0	0
6N.Arenado, 3B	0-0	0	0	0
6N.Gorman, 3B	0-3	1	0	0
7J.Fermin, 2B	1-3	0	0	3
8J.Crooks, C	0-4	0	0	0
9V.Scott, CF	0-2	1	0	0