Brewers vs. Cardinals Odds & Betting Predictions - September 21, 2025

Brewers at Cardinals

6:15 pm • FDSMW

Milwaukee Brewers

95-62

1 - 5

St. Louis Cardinals

77-80

pitcher		team	era	w-l
M.Liberatore			4.21	8-12
R.Gasser			6.00	0-1

MatchupOpenSpreadTotalMoneyline
Brewers 95-62	-1.5	-1.5+125	o8.5-110	-132
Cardinals 77-80	u9	+1.5-150	u8.5-110	+113

Sunday 6:15 p.m.

September 21, 2025

Busch StadiumSt. Louis

Under 8.5-105

0.5u

Could see this as a potential rest spot for some Milwaukee bats with their magic number down to 1 to clinch division. Cardinals already sitting Arenado/Donovan/Pozo and starting five LHB vs the lefty Gasser, so it sets up well for Gasser. Can wait for MIL lineup as they still need to win this game to clinch and Cardinals aren’t playing for anything, but like how this matches up for Gasser and think Liberatore could be in a good spot too if Brewers rest someone like Contreras (who has played five straight games)

No props found

MLB Public Betting

Cardinals are 3-2 in their last 5 games.
Cardinals are 4-1 in their last 5 games against the spread
Cardinals are 38-38 in their road games against the spread
The totals have gone OVER in 2 of Cardinals' last 5 games
The totals have gone OVER in 39 of Cardinals' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cardinals	79-78	41-40	38-38	25-41	53-37
Brewers	86-71	39-39	47-32	42-50	43-21

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cardinals	78-72-7	39-39-3	39-33-4	33-28-5	44-44-2
Brewers	76-76-5	37-38-3	39-38-2	49-41-2	27-34-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cardinals	77-80	44-37	33-43	33-33	43-47
Brewers	95-62	51-27	44-35	58-34	36-28

date	opponent	score	spread	over/under	moneyline
Sep 20th	MIL	L 2-3	+1.5 W	U 8.5	MIL +121
Sep 20th	MIL	W 7-1	+1.5 W	O 7.5	-
Sep 17th	CIN	L 2-6	+1.5 L	U 8.5	CIN +102
Sep 16th	CIN	W 3-0	+1.5 W	U 8	STL +105
Sep 15th	CIN	L 6-11	+1.5 L	O 8.5	CIN -113

Jordan Montgomery
SP
Montgomery is out for season with elbow
Out for Season
Easton McGee
SP
McGee is out with arm
Out
Garrett Mitchell
CF
Mitchell is out with oblique
Out

Nolan Gorman
2B
Nolan Gorman has been scratched Sunday.
Out
Jose Fermin
2B
Jose Fermin scratched Tuesday.
Out
Brendan Donovan
2B
Brendan Donovan has been scratched Monday.
Out
Masyn Winn
SS
Masyn Winn (knee) has been scratched Friday.
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
LR.Gasser, P	45	3	2	2
RE.Fedde, P	56	4	1	3
LR.Zastryzny, P	5	0.2	1	0
RG.Anderson, P	14	0.1	0	0

HITTERS	H-AB	R	RBI
1J.Chourio, RF	0-4	0	1
2I.Collins, LF	0-3	0	0
3A.Vaughn, 1B	0-4	0	0
4R.Hoskins, DH	0-3	0	0
4C.Yelich, PH	0-1	0	0
4C.Yelich, DH	0-1	0	0
5C.Durbin, 3B	0-2	0	0
6A.Monasterio, 2B	3-4	0	0
7D.Jansen, C	0-4	0	0
8B.Perkins, CF	2-3	0	0
8B.Turang, PH	0-1	0	0
9J.Ortiz, SS	2-3	1	0
9J.Bauers, PH	0-0	0	0

PITCHER	PC	IP	K	ER
LM.Liberatore, P	85	5	6	1
RM.Svanson, P	35	2	2	0
RR.Fernandez, P	16	1	2	0
RR.O'Brien, P	15	1	0	0

HITTERS	H-AB	R	HR	RBI
1T.Saggese, SS	0-4	0	0	0
2I.Herrera, DH	1-2	2	1	2
3A.Burleson, 1B	1-3	0	0	0
4L.Nootbaar, LF	0-3	0	0	0
4N.Church, LF	0-0	0	0	0
5J.Walker, RF	0-2	1	0	0
6N.Arenado, 3B	0-0	0	0	0
6N.Gorman, 3B	0-3	1	0	0
7J.Fermin, 2B	1-3	0	0	3
8J.Crooks, C	0-4	0	0	0
9V.Scott, CF	0-2	1	0	0