| Alex Berenguer | F | Out | Suspended | Suspended | Feb 27 |
| Yuri Berchiche | DEF | Out | Suspended | Suspended | Feb 11 |
| Andoni Gorosabel | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Feb 20 |
| Oihan Sancet | MID | Out indefinitely | None | Sancet is injured | Aug 15 |
| Unai Gomez | MID | Out indefinitely | None | Gomez is injured | Aug 15 |
| Benat Prados | MID | Out indefinitely | None | Prados is injured | Aug 15 |
| Unai Egiluz | DEF | Out indefinitely | None | Egiluz is injured | Aug 15 |
| Marcus Rashford | F | Out indefinitely | None | Rashford is injured | May 2 |
| Oriol Romeu | MID | Out | Suspended | Suspended | Dec 14 |
| Robert Lewandowski | F | Out indefinitely | Hamstring | Hamstring | Mar 14 |
| Marc-Andre Ter Stegen | GK | Out indefinitely | Illness | Illness | May 10 |
| Dani Olmo | MID | Out indefinitely | None | Olmo is injured | Sep 15 |
| Raphinha | F | Out | Suspended | Suspended | Apr 1 |
| Jules Kounde | DEF | Out indefinitely | None | Kounde is injured | May 2 |
| Ferran Torres | F | Out indefinitely | None | Torres is injured | May 24 |
| Pedri | MID | Out indefinitely | Hamstring | Hamstring | Apr 11 |
| Daniel Rodriguez | MID | Out indefinitely | None | Rodriguez is injured | Aug 16 |
| Javier Ontiveros | F | Out | Shoulder Injury | Shoulder Injury | Apr 27 |
| Marcos Alonso | DEF | Out indefinitely | Knock | Knock | Sep 5 |
| Franco Cervi | F | Out | Suspended | Suspended | Oct 2 |
| Ilaix Moriba | MID | Out indefinitely | Hamstring | Hamstring | Dec 28 |
| Carl Starfelt | DEF | Out indefinitely | None | Starfelt is injured | Aug 16 |
| Mariano Diaz | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jan 13 |
| Moussa Diarra | DEF | Suspended | None | Diarra is suspended | May 23 |
| Ander Guevara | MID | Out indefinitely | Hamstring | Hamstring | Feb 14 |
| Raul Fernandez | GK | Doubtful | None | Fernandez is doubtful | May 18 |
| Adam Boayar Benaisa | F | Out | None | Boayar Benaisa is out | Aug 17 |
| Pere Milla | MID | Out | Suspended | Suspended | Mar 19 |
| Javier Hernandez | MID | Out indefinitely | None | Hernandez is injured | Aug 15 |
| Borja Mayoral | F | Doubtful | None | Mayoral is doubtful | Aug 15 |
| Kiko Femenia | DEF | Out indefinitely | None | Femenia is injured | Aug 16 |
| Juanmi | F | Doubtful | None | Juanmi is doubtful | Aug 14 |
| Jiri Letacek | GK | Doubtful | None | Letacek is doubtful | Aug 14 |
| Mubarak Wakaso | MID | Out | Suspended | Suspended | Jan 18 |
| Daley Blind | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 15 |
| Thomas Lemar | MID | Out indefinitely | Knee Injury | Knee Injury | Feb 27 |
| Axel Witsel | MID | Out indefinitely | Knock | Knock | May 2 |
| Yangel Herrera | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Apr 4 |
| Miguel Gutierrez | DEF | Doubtful | None | Gutierrez is doubtful | Aug 16 |
| Ricard Artero Ruiz | MID | Out indefinitely | None | Artero Ruiz is injured | Aug 14 |
| Bojan Miovski | F | Out indefinitely | None | Miovski is injured | May 24 |
| Manu Sanchez | MID | Out indefinitely | Hamstring | Hamstring | May 12 |
| Omar Mascarell | MID | Out | Suspended | Suspended | Feb 15 |
| Sergi Darder | MID | Out | Virus | Virus | Jan 17 |
| Cyle Larin | F | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Mar 8 |
| Takuma Asano | F | Out indefinitely | Knee Injury | Knee Injury | Nov 11 |
| Pablo Maffeo | DEF | Out | Suspended | Suspended | Nov 9 |
| Martin Valjent | DEF | Out indefinitely | Back Injury | Back Injury | Apr 11 |
| Vedat Muriqi | F | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Nov 28 |
| Manu Morlanes | MID | Suspended | None | Morlanes is suspended | Aug 17 |
| Samu Costa | MID | Out indefinitely | None | Costa is injured | Aug 16 |
| Ivan Cuellar | GK | Out indefinitely | None | Cuellar is injured | Aug 15 |
| M. Peybernes | DEF | Out | Suspended | Suspended | Feb 19 |
| Juanfran | DEF | Out indefinitely | Hamstring | Hamstring | Nov 26 |
| Weligton Róbson Pena de Oliveira | DEF | Out indefinitely | Knee Injury | Knee Injury | Jun 9 |
| Juan Carlos Pérez López | DEF | Out | Suspended | Suspended | Jan 5 |
| Miguel Torres Gómez | DEF | Out | Hamstring | Hamstring | May 24 |
| Sérgio Paulo Barbosa Valente | MID | Out indefinitely | Toe Injury | Toe Injury | May 22 |
| Keko | MID | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | May 5 |
| Zdravko Kuzmanović | MID | Out indefinitely | Pubalgia | Pubalgia | Jun 12 |
| Jozabed | MID | Out | Suspended | Suspended | Jan 22 |
| Pablo Hervías | MID | Out indefinitely | Cartilage Knee Injury | Cartilage Knee Injury | Apr 6 |
| Adrián | A | Out indefinitely | Knock | Knock | Jun 15 |
| Brandon Thomas Llamas | A | Out | Suspended | Suspended | Jan 3 |
| C. Gönen | GK | Out indefinitely | Shoulder Injury | Shoulder Injury | Jun 12 |
| L. Agbenyenu | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Jul 17 |
| Joaquín Muñoz | A | Out | Suspended | Suspended | Mar 27 |
| P. Chavarría | A | Out indefinitely | Knock | Knock | Sep 29 |
| E. Burgos | DEF | Out | Suspended | Suspended | Feb 20 |
| M. Benkhemassa | MID | Out | Suspended | Suspended | Jan 26 |
| Caye Quintana | A | Out | Suspended | Suspended | Dec 5 |
| Jonás Ramalho | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Nov 22 |
| Genaro Rodríguez | MID | Out | Suspended | Suspended | Jan 15 |
| Ante Budimir | F | Out indefinitely | Pubalgia | Pubalgia | Oct 25 |
| Lucas Torro | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | May 23 |
| Sergio Herrera | GK | Out indefinitely | Knee Injury | Knee Injury | Nov 9 |
| Iker Benito | F | Doubtful | None | Benito is doubtful | Aug 15 |
| M. Koné | A | Out | Suspended | Suspended | Jan 12 |
| Raúl Carnero | DEF | Out | Suspended | Suspended | Mar 19 |
| Fernando Navarro i Corbacho | DEF | Out | Suspended | Suspended | Apr 1 |
| Rober | DEF | Out indefinitely | Knock | Knock | Nov 29 |
| Ivan Balliu | DEF | Out | Suspended | Suspended | Oct 17 |
| Oscar Trejo | F | Out | Calf Muscle Strain | Calf Muscle Strain | Jun 5 |
| Luiz Felipe | DEF | Out indefinitely | Hamstring | Hamstring | Apr 4 |
| Abdul Mumin | DEF | Out indefinitely | None | Mumin is injured | Aug 14 |
| Hector Bellerin | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Oct 29 |
| Adrian | GK | Out indefinitely | Calf/Shin Injury | Calf/Shin Injury | Jan 3 |
| Marc Roca | MID | Out indefinitely | None | Roca is injured | Aug 15 |
| Diego Llorente | DEF | Out indefinitely | None | Llorente is injured | Aug 15 |
| Pablo Fornals | MID | Out indefinitely | None | Fornals is injured | Jan 20 |
| Junior Firpo | DEF | Out | Knee Injury | Knee Injury | Sep 3 |
| Cucho Hernandez | F | Out | Thigh Muscle Strain | Thigh Muscle Strain | May 22 |
| Abde Ezzalzouli | F | Out | Suspended | Suspended | Feb 12 |
| Isco | MID | Out indefinitely | None | Isco is injured | Aug 15 |
| Nelson Deossa | MID | Doubtful | None | Deossa is doubtful | Aug 15 |
| Lucas Ahijado | DEF | Doubtful | None | Ahijado is doubtful | Aug 16 |
| Santiago Colombatto | MID | Doubtful | None | Colombatto is doubtful | Aug 16 |
| Alberto Reina Campos | F | Suspended | None | Reina Campos is suspended | Aug 16 |
| Umar Sadiq | F | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Apr 11 |
| Carlos Fernandez | F | Out indefinitely | None | Fernandez is injured | Jan 19 |
| Goncalo Guedes | MID | Out | Knock | Knock | Apr 21 |
| Duje Caleta-Car | DEF | Out | Virus | Virus | Aug 14 |
| Hamari Traore | DEF | Out | Calf Muscle Strain | Calf Muscle Strain | Mar 11 |
| Orri Oskarsson | F | Out indefinitely | None | Oskarsson is injured | May 3 |
| Y. Muto | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Apr 26 |
| Matheus Pereira | MID | Out | Suspended | Suspended | Oct 30 |
| Etxeita | DEF | Out | Suspended | Suspended | Apr 23 |
| Anaitz Arbilla Zabala | DEF | Out | Suspended | Suspended | Mar 13 |
| Iván Ramis Barrios | DEF | Out indefinitely | Knee Injury | Knee Injury | Jul 24 |
| Francisco Manuel Rico Castro | MID | Out indefinitely | Knee Injury | Knee Injury | Jun 30 |
| Imanol Sarriegui Isasa | MID | Out | Hand Injury | Hand Injury | Mar 7 |
| Roberto Antonio Correa Silva | DEF | Out | Suspended | Suspended | Jan 8 |
| Paulo Oliveira | DEF | Out indefinitely | Hamstring | Hamstring | Dec 29 |
| G. Blanco | A | Out | Suspended | Suspended | Jan 10 |
| Javi Muñoz | MID | Out | Suspended | Suspended | Apr 1 |
| Enrique González Casín | A | Out indefinitely | Knock | Knock | Dec 23 |
| Peru Nolaskoain | DEF | Out | Suspended | Suspended | Jan 15 |
| Juan Berrocal | DEF | Out | Suspended | Suspended | Mar 7 |
| S. Okazaki | A | Out indefinitely | Hamstring | Hamstring | Nov 9 |
| Mikel Rico | MID | Out indefinitely | Virus | Virus | Nov 9 |
| Pablo Ínsua Blanco | DEF | Out | Suspended | Suspended | Apr 2 |
| Timor | MID | Out indefinitely | Knock | Knock | Dec 20 |
| Luisinho | DEF | Out indefinitely | Knee Injury | Knee Injury | May 22 |
| Juan Pablo Añor Acosta | MID | Out indefinitely | Hamstring | Hamstring | May 1 |
| Juan Pérez | GK | Out indefinitely | Arm/Elbow injury | Arm/Elbow injury | Dec 20 |
| Cristian Salvador | MID | Out | Suspended | Suspended | Jan 9 |
| Óscar Sielva | MID | Out | Suspended | Suspended | Feb 26 |
| Gerard Valentín | DEF | Out indefinitely | Hamstring | Hamstring | Dec 26 |
| Eugeni Valderrama | MID | Out indefinitely | Hamstring | Hamstring | May 22 |
| K. Nwakali | MID | Out indefinitely | Knock | Knock | Oct 18 |
| Pedro López Muñoz | DEF | Out indefinitely | Hamstring | Hamstring | Nov 9 |
| Juan Carlos | | Out | Virus | Virus | Jan 31 |
| Pablo Martínez | MID | Out | Suspended | Suspended | Oct 31 |
| Djibril Sow | MID | Out indefinitely | Knock | Knock | Jun 14 |
| Orjan Nyland | GK | Out indefinitely | Back Injury | Back Injury | Feb 14 |
| Dodi Lukebakio | F | Out indefinitely | Virus | Virus | Jan 17 |
| Rafa Mir | F | Out indefinitely | Knock | Knock | Apr 4 |
| Joan Jordan | MID | Out indefinitely | None | Jordan is injured | Aug 15 |
| Lucien Agoume | MID | Out | Thigh Muscle Strain | Thigh Muscle Strain | Jan 19 |
| Chidera Ejuke | F | Out indefinitely | Knee Injury | Knee Injury | Apr 11 |
| Loic Bade | DEF | Out indefinitely | Hamstring | Hamstring | Feb 25 |
| Tanguy Nianzou | DEF | Out indefinitely | None | Nianzou is injured | Aug 15 |
| Ramon Martinez Gil | DEF | Out indefinitely | None | Martinez Gil is injured | Aug 15 |
| Alejandro Bergantiños García | MID | Out | Suspended | Suspended | Mar 11 |
| Javi Fuego | MID | Out | Suspended | Suspended | Mar 26 |
| Álvaro Vázquez | A | Out | Shoulder Injury | Shoulder Injury | Sep 12 |
| Jony | MID | Out | Suspended | Suspended | Feb 12 |
| Pichu Cuéllar | GK | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Mar 1 |
| J. Babin | DEF | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Feb 25 |
| Fernando Amorebieta Mardaras | DEF | Out indefinitely | Knock | Knock | Apr 3 |
| Pedro Díaz Fanjul | MID | Out | Suspended | Suspended | May 10 |
| Juan Rodríguez Martínez | DEF | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | May 1 |
| Sergio Álvarez Díaz | MID | Out | Suspended | Suspended | Feb 12 |
| José Ángel Valdés Díaz | DEF | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Aug 24 |
| Jordi Calavera Espinach | DEF | Out indefinitely | Knock | Knock | Apr 22 |
| Pablo Pérez | MID | Out | Suspended | Suspended | May 7 |
| Molinero | DEF | Out | Suspended | Suspended | Jul 6 |
| Marc Valiente | DEF | Out | Suspended | Suspended | Nov 30 |
| J. Otero | A | Out | Suspended | Suspended | Dec 14 |
| Víctor Campuzano | A | Out indefinitely | Back Injury | Back Injury | Mar 1 |
| Vasyl Kravets | DEF | Out | Suspended | Suspended | Jan 23 |
| Fran Villalba | MID | Out | Suspended | Suspended | Apr 2 |
| José Marsà | DEF | Out | Suspended | Suspended | Apr 8 |
| Luis Javier Suarez | F | Out | Suspended | Suspended | Apr 22 |
| Houboulang Mendes | DEF | Out | Knee Injury | Knee Injury | Jan 24 |
| Marko Marezi | F | Out indefinitely | Pubalgia | Pubalgia | Oct 29 |
| Dimitri Foulquier | DEF | Out indefinitely | Hamstring | Hamstring | Jan 20 |
| Stole Dimitrievski | GK | Doubtful | None | Dimitrievski is doubtful | Aug 15 |
| Thierry Correia | DEF | Out indefinitely | Hamstring | Hamstring | Feb 27 |
| Alberto Mari | F | Out indefinitely | None | Mari is injured | Aug 14 |
| Hugo Guillamon | DEF | Out | Suspended | Suspended | Feb 11 |
| Thomas Partey | MID | Out | Back Injury | Back Injury | Feb 25 |
| Denis Suarez | MID | Doubtful | None | Suarez is doubtful | Aug 14 |
| Gerard Moreno | F | Doubtful | None | Moreno is doubtful | Aug 16 |
| Ayoze Perez | F | Out indefinitely | Illness | Illness | Dec 27 |
| Juan Foyth | DEF | Out indefinitely | Knee Injury | Knee Injury | Nov 7 |
| Diego Conde | GK | Doubtful | None | Conde is doubtful | Aug 16 |
Ghana
Málaga CF
RC Deportivo La Coruna
SD Eibar
SD Huesca
Sporting Gijón
