The English Premier League is entering its defining stages. With the leaders looking to keep the chasing pack behind and margins continuously shrinking, each new Premier League matchday brings a surge of betting opportunities.
We have five matches to target on Sunday's EPL schedule, and our staff has come up clutch with picks for all of them. So, continue reading for our Premier League best bets for Saturday, April 25.
English Premier League Best Bets
The club logos in the table below represent each match that our soccer betting staff is targeting from today's games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Match | Time (ET) | Pick |
|---|---|---|
  | 7:30 a.m. | |
  | 10 a.m. | |
  | 10 a.m. | |
  | 10 a.m. | |
  | 12:30 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our soccer Odds page, which automatically surfaces the best lines for every game. | ||
Aston Villa vs. Fulham
On paper, Villa are the stronger side here, but the bookmakers assign the same chances of victory to each side. That’s perhaps because, with the Europa League semi-final first leg coming up next week, Aston Villa might rest some of their best players this Saturday.
Although only one of Fulham’s last five Premier League matches produced goals on both sides, both teams scored in 58% of their matches this season, and in 63% of their Craven Cottage games.
Both teams scored in five of Aston Villa’s previous seven Premier League games and in three of their last four away matches.
Villa were better in a reverse fixture back in September 2025, when they celebrated a 3-1 home victory, while four of the last five head-to-head meetings have seen goals on both ends.
Pick: Both Teams To Score – Yes
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Crystal Palace vs. Liverpool
It’s been a difficult season for Liverpool, but their recent results mean they are close to clinching Champions League football for next season, and a win over Crystal Palace would put them in a strong position. They have also lost just three of their 16 league games at Anfield this season, winning nine. During that run, Liverpool has scored an average of 1.81 goals per game
Crystal Palace, on the other hand, has averaged one goal per league game in 2026; only Wolves have averaged fewer goals per game in the Premier League this calendar year.
The Eagles have done reasonably well at Anfield in recent years. However, Oliver Glasner’s side will have one eye on their Conference League away game against Shakhtar, so we are backing the home side to win this game.
Pick: Liverpool To Win
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Everton vs. West Ham United
Both teams enter the weekend’s fixture needing a result at opposite ends of the table, but both need a win. Everton remains just one point behind Chelsea, in 7th place and the final European position. Meanwhile, West Ham sits two points ahead of Spurs in 17th, with relegation to the Championship a very real concern.
This pick has won in over 50% of Premier League matches this season, in a division averaging 2.74 goals per 90 minutes. At home, West Ham have seen both teams score in 63% of matches. On the road, Everton’s strike-rate isn’t as reassuring (44%), although they’ve scored in five of the last six matches.
With the season’s end in sight and teams across the division desperately needing three points, this has all the hallmarks of a ‘both teams to score – yes’ fixture.
Pick: Both Teams To Score – Yes
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Tottenham vs. Wolverhampton Wanderers
Despite still having mathematical chances, Wolves are set to be relegated from the Premier League this season. This gives Rob Edwards's team a chance to play for pride in front of supporters and further assess his squad in competitive matches before the Championship campaign next term.
Meanwhile, the need for a win has ramped up for 18th-placed Tottenham with Roberto De Zerbi’s appointment. The Spurs’ best performances have been reserved for their away fixtures. Tottenham have won five of 16 away days, returning nine more points than the 11 secured in North London.
The mismatch in desire between the dressing rooms; all signs point to a Spurs win. The bookmakers agree, pricing Spurs as odds-on favorites despite their poor recent form. After all, Wolves have lost ten of 16 home matches in 2025/26.
Pick: Tottenham To Win
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Newcastle United vs. Arsenal
The performance at the Etihad against Manchester City still offered encouragement for Arsenal, who look unlikely to relinquish their title challenge easily.
However, Arsenal have struggled to create chances throughout the season, a trend reflected in their output from open play. They have recorded 35.8 expected goals from open play this season, ranking them sixth in the league.
The Magpies have conceded 20 goals across their last 10 Premier League outings, the worst record in the division, following an eighth defeat in 11 league games. No other side has conceded more late goals (19) than Newcastle in the league this season.
Eddie Howe’s side has become too easy to play against, and while Arsenal's play makes it difficult to envision a high-scoring victory for Mikel Arteta’s side, Arsenal are expected to collect all three points.
Pick: Arsenal To Win and Under 2.5 Goals
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